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Dendrobium candidum chewable tablet

A technology of Dendrobium officinale and chewable tablets, which is applied in the directions of plant raw materials, pill delivery, plant/algae/fungus/moss components, etc., can solve the problems of high energy consumption, low dissolution rate of active ingredients, poor fluidity, etc., and achieve high dissolution rate , Conducive to intestinal absorption and overcome the effect of poor fluidity

Inactive Publication Date: 2013-02-06
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the above-mentioned patent application crushes Dendrobium candidum to below 50 μm, which obviously has the defects of high energy consumption and low dissolution rate of active ingredients.
In addition, everyone with a little production experience knows that the fluidity of raw materials is poor when they are pressed into tablets

Method used

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  • Dendrobium candidum chewable tablet
  • Dendrobium candidum chewable tablet
  • Dendrobium candidum chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Example 1 (Study on the dissolution rate of active ingredients in different particle sizes of Dendrobium officinale micropowder and the absorption effect in the small intestine)

[0018] 1 Preparation of superfine powder of Dendrobium officinale

[0019] The commercially available fresh Dendrobium candidum was dried at 65°C and pulverized by a JZL series fluidized bed jet milling classifier to obtain particle sizes ranging from 190-75 μm, 70-65 μm, 58-55 μm, 53-40 μm, 37-34 μm, Dendrobium candidum micropowder with seven different particle sizes of 30~15μm and 10~1μm.

[0020] 2 Study on the dissolution rate of active ingredient Dendrobium polysaccharides in different particle sizes of Dendrobium officinale micropowder

[0021] 2.2.1 Preparation of reference solution

[0022] Take anhydrous glucose and add water to make a reference substance solution containing 90 μg glucose per 1 ml.

[0023] 2.2.2 Establish standard curve

[0024] Precisely measure 0.2ml, 0.4ml, 0....

example 2

[0064] Example 2 (preparation example of chewable tablet)

[0065] 1. Prescription

[0066] Dendrobium candidum 100g, microcrystalline cellulose 47g, lactose 47g, mannitol 156g, citric acid 8g, micronized silica gel 1.6g.

[0067] 2. Preparation method

[0068] Dendrobium candidum was crushed into a fine powder with a particle size of 34-58 μm by a JZL series fluidized bed crushing and classifying machine, added microcrystalline cellulose, lactose, mannitol, citric acid and micro-powdered silica gel, mixed evenly, and directly compressed into 100 chewable tablets .

[0069] 3. Detection of accumulated absorption concentration in the small intestine

[0070] Adopt the same method as Example 1 to measure the intestinal cumulative absorption concentration (mg / ml) of the chewable tablet made in this example as shown in the following table:

[0071]

example 3

[0072] Example 3 (preparation example of chewable tablet)

[0073] 1. Prescription

[0074] Dendrobium candidum 100g, pregelatinized starch 171g, aspartame 5.7g, talcum powder 8.57g.

[0075] 2. Preparation method

[0076] Dendrobium candidum was crushed into fine powder with a particle size of 34-58 μm by JZL series fluidized bed crushing and classifying machine, pregelatinized starch, aspartame and talcum powder were added, mixed evenly, and directly compressed into 100 chewable tablets.

[0077] 3. Detection of accumulated absorption concentration in the small intestine

[0078] Adopt the same method as Example 1 to measure the intestinal cumulative absorption concentration (mg / ml) of the chewable tablet made in this example as shown in the following table:

[0079]

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Abstract

The invention relates to a dendrobium candidum chewable tablet. The chewable tablet consists of dendrobium candidum fine powder and medicinal acceptable auxiliary materials, and is characterized in that: the particle diameter of the dendrobium candidum fine powder is 34-58 mum. The dendrobium candidum chewable tablet disclosed by the invention has high polysaccharide dissolution rate, and contributes to intestinal absorption of active ingredients; and the bioavailability of a preparation can be improved remarkably.

Description

technical field [0001] The invention relates to a pharmaceutical preparation with undetermined structure from plants of the genus Dendrobium, in particular to a tablet of Dendrobium officinale. technical background [0002] Dendrobium candidum is a traditional precious Chinese medicinal material in my country. It has been known as "the gold in medicine" since ancient times. The Taoist medical classic "Tao Zang" listed Dendrobium candidum as the first of the "nine immortal grasses", and the folks called it "life-saving immortal grass". . "Shen Nong's Materia Medica" records that Dendrobium candidum "mainly injures, eliminates numbness, lowers qi, nourishes five viscera, strengthens yin, thickens stomach after long-term use"; Li Shizhen evaluated Dendrobium candidum as "strengthening yin and benefiting essence" in "Compendium of Materia Medica" , thicken the intestines and stomach, nourish the deficiency of the internal organs, calm the stomach qi, stretch the muscles, improve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61K9/20
Inventor 魏小勇陈丹
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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