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Norcantharidin/layered double hydroxide nano hybrid and preparation method thereof

A technology of norcanthin and nano-hybrids, which is applied in the direction of active ingredients of heterocyclic compounds, pharmaceutical formulations, drug combinations, etc., can solve the problems of ordinary preparations such as ineffective treatment, high toxicity, and skin irritation, and achieve good results. Sustained release effect, reduction of toxic and side effects, mild reaction effect

Inactive Publication Date: 2013-02-13
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, NCTD is highly toxic and highly irritating to the epidermis. The human body can be poisoned after taking a small amount. In the human body, it is difficult to reach an effective blood concentration, especially in the lesion of liver cancer. Therefore, the therapeutic effect of common NCTD preparations is not obvious.

Method used

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  • Norcantharidin/layered double hydroxide nano hybrid and preparation method thereof
  • Norcantharidin/layered double hydroxide nano hybrid and preparation method thereof
  • Norcantharidin/layered double hydroxide nano hybrid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step a: 2.44g (0.012mol) MgCl 2 ·6H 2 O and 1.45g (0.006mol) AlCl 3 9H 2 O was dissolved in 36 mL of deionized water.

[0031] Step b: 1.01 g (0.006 mol) of solid norcantochelin was dissolved in 42 mL of NaOH solution with a concentration of 1 mol / L.

[0032] Step c: Add the solution of step b to the solution of step a, stir, control the pH to 9, and the reaction temperature to 65°C; then age the obtained slurry at 65°C for 3 hours, filter, wash with water until neutral, and age at 80°C After 24 hours, the norcanthin / LDHs nano-hybrid product was obtained; after drying, the powder product was obtained.

[0033] By XRD spectrum ( figure 1 a) It can be seen that the norcanthin / LDHs nano-hybrid has a layered crystal structure, and the interlayer spacing (d 003 ) shows that norcanthin has been inserted into the interlayer of LDHs.

[0034] From the IR spectrum ( figure 2 b) It was further confirmed that norcanchelin had intercalated into the interlayer.

[0035] Th...

Embodiment 2

[0038] Step a: 2.44g (0.012mol) MgCl 2 ·6H 2 O and 1.45g (0.006mol) AlCl 3 9H 2 O was dissolved in 36 mL of deionized water.

[0039] Step b: 2.02 g (0.012 mol) of solid norcantochelin was dissolved in 42 mL of NaOH solution with a concentration of 1 mol / L.

[0040] Step c: Add the solution of step b to the solution of step a, stir, control the pH to 9.5, and the reaction temperature to 65°C; then age the obtained slurry at 65°C for 6 hours, filter, wash with water until neutral, and age at 80°C After 28 hours, the norcanthin / LDHs nano-hybrid product was obtained; after drying, the powder product was obtained.

[0041] By XRD spectrum ( figure 1 b) shows that the norcanthin / LDHs nano-hybrid has a layered crystal structure, and the interlayer spacing (d 003 ) shows that norcanthin has been inserted into the interlayer.

[0042] From the IR spectrum ( figure 2 c) It was further confirmed that norcantochelin had intercalated into the interlayer.

[0043] For the results...

Embodiment 3

[0046] Step a: 2.44g (0.012mol) MgCl 2 ·6H 2 O and 1.45g (0.006mol) AlCl 3 9H 2 O was dissolved in 36 mL of deionized water.

[0047] Step b: 5.04 g (0.018 mol) of solid norcantharin was dissolved in 50 mL of NaOH solution with a concentration of 1 mol / L.

[0048] Step c: Add the solution of step b to the solution of step a, stir, control the pH to 9.5, and the reaction temperature to 70°C; then age the obtained slurry at 70°C for 3 hours, filter, wash with water until neutral, and age at 80°C After 26 hours, the norcanthin / LDHs nano-hybrid product was obtained; after drying, the powder product was obtained.

[0049] By XRD spectrum ( figure 1 c) It can be seen that the norcantochelin / LDHs nano-hybrid has a layered crystal structure, and from the interlayer distance (d003), it can be known that norcantochelin has been inserted into the interlayer of LDHs.

[0050] The sample was analyzed by ultraviolet spectrophotometry, and the content of norcantharin was determined to ...

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Abstract

The invention relates to a norcantharidin / layered double hydroxide (LDHs) nano hybrid and preparation method thereof. An LDHs is provided and serves as a carrier, the norcantharidin / LDHs nano hybrid is prepared, and the controlled release of the norcantharidin is achieved, so that the medical effect is improved, and the toxic and side effect of medicines is reduced. The method comprises that the LDHs serves as a main body, the norcantharidin is an intercalated object, the norcantharidin is assembled among LDHs layers through a coprecipitation method, and the norcantharidin / LDHs nano hybrid is prepared. The method has the advantages that the hybrid has a good slow-release effect for the norcantharidin; the process is simple and reaction is mild; and the synthesis conditions of the norcantharidin / LDHs nano hybrid are regulated, for instance, the concentration, the synthesis temperature, the ageing time and the like of medicines are changed, so that control of the structure, components and the release rate of the norcantharidin / LDHs nano hybrid can be achieved.

Description

technical field [0001] The invention belongs to the technical field of materials and pharmaceutical preparations, and relates to a norcantochelin / layered double metal hydroxide (LDHs) nano hybrid and a preparation method thereof. Background technique [0002] With the development of science and the advancement of science and technology, people's requirements for the treatment effect and treatment methods of diseases are increasing day by day. How to improve the curative effect, simplify the way of medication, and reduce the toxic and side effects of drugs is the research focus of scientific and technological workers. Especially for highly toxic drugs, in order to facilitate patients to take them, while ensuring the effective therapeutic concentration, reduce the toxic and side effects of drugs, and avoid the emergence of drug resistance, the effective delivery and controlled release of drugs is undoubtedly an effective method. way. In this effective approach, the developme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/02A61K31/34A61P35/00
Inventor 赵军徐洁
Owner QINGDAO UNIV OF SCI & TECH
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