Preparation method and application for hydrophilic organic polymer liquid phase monolithic chromatographic column

An integral chromatographic column and polymer technology, which is applied in the field of chromatographic research of organic polymer materials, can solve the problems of limited application optimization range, limited polarity of chromatographic column, narrow range of solvent selection, etc., and achieves low cost, less environmental pollution, and preparation The effect of simple process
CN102940980AActive Publication Date: 2013-02-27JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2013-02-27

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Abstract

The invention belongs to the research field of organic polymeric materials, and discloses a preparation method and an application for a hydrophilic organic polymer liquid phase monolithic chromatographic column. The method comprises the following steps of employing monomers of 3-[N,N-dimethyl-[2-(2-enoyloxy)ethyl]butylamin]propane-1-sulfonate as functional monomers, mixing the functional monomers with a cross-linking agent, a pore-forming agent and an initiator, performing a thermocatalytic reaction, and carrying out in-situ polymerization in a quartz capillary to form the polymer liquid phase monolithic chromatographic column. The obtained chromatographic column has larger hydrophilic interaction area than a common hydrophilic chromatographic column. The monolithic chromatographic column is small in usage amount of the organic mobile phase, has little environmental pollution, is simple in preparation process and low in cost, has low column pressure, and is suitable for rapid separation of polar compounds.
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Description

technical field

[0001] The invention belongs to the field of chromatographic research on organic polymer materials, and in particular relates to a method and application for in-situ preparation of a monolithic column of a hydrophilic organic polymer through thermal polymerization technology. Background technique

[0002] As we all know, liquid chromatography and its combined technology have been widely used in the fields of environment, medicine and life sciences, and the research on its core components, chromatographic separation media and analysis functions, is also deepening. In recent years, new monolithic materials for chromatographic stationary phases have become one of the research hotspots due to their advantages of high permeability, low column pressure, fast mass transfer, and simple preparation, and have been successfully used in reversed-phase chromatography, ion-exchange chromatography, Applied in separation modes such as affinity chromatography, it effectively s...

Claims

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