Method for preparing high-purity lycium barbarum acid

A medlaric acid, high-purity technology is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., to achieve the effects of quality improvement, simple method, great application value and social benefits

Active Publication Date: 2013-02-27
SHANGHAI NOVANAT BIORESOURCES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is no commercially available wolfberry acid at present, it i

Method used

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  • Method for preparing high-purity lycium barbarum acid
  • Method for preparing high-purity lycium barbarum acid
  • Method for preparing high-purity lycium barbarum acid

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Weigh 1 kg of dried wolfberry fruit produced in Ningxia, add 30% acetonitrile (15 liters), soak at room temperature (23~27°C) for 4 hours, put it into a food blender and grind it, continue soaking for 10 hours, and use a high-speed centrifuge at 8000 rpm Centrifuge and soak the material for 10 minutes to remove the plant slag, and then filter the obtained material liquid with a stainless steel plate and frame filter to obtain 12.8 liters of clear material liquid after treatment. The feed liquid was vacuum-concentrated at -0.09~-0.95 MPa and 55~65°C with a rotary evaporator until there was no acetonitrile. Obtain 6 liters of aqueous feed solution, add this feed solution in the D-101 macroporous adsorption resin column that 1000 milliliters cleans through the head tank, control the flow rate of passing liquid to be 1 column volume / hour, after loading the column, use 1000 milliliters Water replaced the feed liquid in the column to obtain 7 liters of feed liquid through the...

Embodiment 2

[0040] Weigh 1 kg of dried fruit of Lycium barbarum produced in Xinjiang, add an appropriate amount of 30% ethanol, grind them all in a food blender, add 30% ethanol to add enough to 15 liters, and reflux for 3 hours. After the extract is cooled to 23~27°C,

[0041]Use a high-speed centrifuge to centrifuge and soak the material at 8000 rpm to remove plant slag, and the resulting feed liquid is filtered with a stainless steel plate and frame filter to obtain 13.2 liters of clear feed liquid after treatment. The feed liquid was vacuum-concentrated at -0.09~-0.95 MPa and 55~65°C with a rotary evaporator until there was no acetonitrile. Obtain 7 liters of water-based feed liquid, and add this feed liquid to 1000 milliliters of washed AB-8 macroporous adsorption resin columns through the head tank, and control the passing liquid flow rate to be 1 column volume / hour. Water replaced the feed liquid in the column to obtain 8 liters of feed liquid through the column. The collected co...

Embodiment 3

[0045] Weigh 1 kg of dry wolfberry fruit produced in Gansu, add appropriate amount of 15 liters of 20% acetone, soak for 8 hours at 23~27°C, put it into a food blender and grind it, then heat and reflux for 2 hours, after cooling, use a high-speed centrifuge to soak the material out The plant slag was removed, and the obtained feed liquid was filtered with a flat frame filter to obtain 12.3 L of treated clear feed liquid. The feed liquid was concentrated in vacuum with a rotary evaporator at -0.09~-0.95 MPa, 55~65°C until there was no acetone. Obtain 6 liters of aqueous feed solution, add this feed solution to 1000 ml of washed HP20 macroporous adsorption resin column through the head tank, control the flow rate of the passing liquid to be 1 column volume / hour, after the column is loaded, replace it with 1000 ml of water The feed liquid in the column was discharged to obtain 8 liters of feed liquid through the column. The collected column feed liquid passes through the OH typ...

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Abstract

The invention discloses a method for preparing high-purity lycium barbarum acid, comprising the following steps of: extracting a lycium barbarum raw material by means of cold-soaking or heating via a solvent, filtering, concentrating, removing impurities via macroporous resin, enriching with ion exchange fibre enrichment and twice medium-pressure chromatography. Via the method disclosed by the invention, high-purity lycium barbarum acid is prepared, and the content of lycium barbarum acid can achieve more than 95% via high performance liquid chromatographic detection. Lycium barbarum acid prepared by the method disclosed by the invention is a particular symbolic ingredient in lycium barbarum, and can be used as a true-false identification index for lycium barbarum highly-processed products; and the lycium barbarum acid can also play a role of ensuring the quality of the lycium barbarum highly-processed products in case of being subjected to a content measurement simultaneously. The method disclosed by the invention has positive effects on improvement for the processing quality of a lycium barbarum extract and on benefits to human health.

Description

technical field [0001] The invention relates to a method for extracting and preparing herbal medicines, in particular to a method for extracting and preparing high-purity wolfberry acid from Lycium chinense. Background technique [0002] Lycium barbarum is a food that has many benefits to human health and has been widely used. With the improvement of people's living standards, the deep-processing products related to wolfberry are also increasing in recent years. However, the raw materials of wolfberry come from many sources, and the quality is also quite different, which further affects the preparation of wolfberry extract, resulting in the uncontrollable quality of deep-processed products. At present, the requirement for wolfberry extract is only to use the polysaccharide components in the wolfberry extract as the quality index. In fact, in addition to this, there are some other ingredients, such as: flavonoids, wolfberry acid, taurine, betaine, etc., which may affect the...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08
Inventor 殷梦龙杨延超董慧燕李旭孟
Owner SHANGHAI NOVANAT BIORESOURCES CO LTD
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