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Beta-poly malic acid/chitosan nano drug sustained-release microcapsule and preparation method thereof

A chitosan nanometer and slow-release microcapsule technology is applied in drug delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc. It can solve the problems of releasing microcapsules, etc., to achieve the effects of mild conditions, lower production costs, environmental friendliness and no pollution.

Inactive Publication Date: 2013-03-13
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report of combining β-polymalic acid and chitosan to make drug nano-sustained-release microcapsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules, calculated by mass ratio, that is, according to the ratio of β-polymalic acid: chitosan: nifedipine is 10:2.5:4, the β -Polymalic acid, chitosan and nifedipine utilize the principle of polyelectrolyte self-assembly to prepare β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules.

[0032] The preparation method of above-mentioned a kind of β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules specifically comprises the steps:

[0033] (1) Preparation of solution

[0034] Accurately weigh 0.100g of β-polymalic acid solid, and dilute to 100mL with ultrapure water, and the natural pH value, to obtain a β-polymalic acid aqueous solution with a concentration of 1.0mg / mL;

[0035] Accurately weigh 0.050 g of chitosan solids, set the volume to 50 mL with 1% acetic acid solution, adjust the pH value to 4.0 with 10% acetic acid, and obtain a chitosan acetic acid solutio...

Embodiment 2

[0041]A kind of β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules, calculated according to the mass ratio, that is, according to the ratio of β-polymalic acid: chitosan: nifedipine is 10:2.5:5, the β -Polymalic acid, chitosan and nifedipine utilize the principle of polyelectrolyte self-assembly to prepare β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules.

[0042] The preparation method of above-mentioned a kind of β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules specifically comprises the steps:

[0043] (1) Preparation of solution

[0044] Accurately weigh 0.100g of β-polymalic acid solid, and dilute to 100mL with ultrapure water, and the natural pH value, to obtain a β-polymalic acid aqueous solution with a concentration of 1.0mg / mL;

[0045] Accurately weigh 0.050 g of chitosan solids, set the volume to 50 mL with 1% acetic acid solution, adjust the pH value to 4.0 with 10% acetic acid, and obtain a chitosan acetic...

Embodiment 3

[0052] A kind of β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules, calculated by mass ratio, that is, according to the ratio of β-polymalic acid: chitosan: nifedipine is 10:2.5:3, the β -Polymalic acid, chitosan and nifedipine utilize the principle of polyelectrolyte self-assembly to prepare β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules.

[0053] The preparation method of above-mentioned a kind of β-polymalic acid / chitosan nano-nifedipine slow-release microcapsules specifically comprises the steps:

[0054] (1) Preparation of solution

[0055] Accurately weigh 0.100g of β-polymalic acid solid, and dilute to 100mL with ultrapure water, and the natural pH value, to obtain a β-polymalic acid aqueous solution with a concentration of 1.0mg / mL;

[0056] Accurately weigh 0.050 g of chitosan solids, set the volume to 50 mL with 1% acetic acid solution, adjust the pH value to 4.0 with 10% acetic acid, and obtain a chitosan acetic acid solutio...

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PUM

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Abstract

The invention discloses a beta-poly malic acid / chitosan nano drug sustained-release microcapsule and a preparation method thereof. The beta-poly malic acid / chitosan nano drug sustained-release microcapsule comprises a core material and a wall material, wherein the core material is a medicine, and the raw material of the wall material consists of beta-poly malic acid and chitosan; and the mass ratio of beta-poly malic acid to chitosan to the medicine in the beta-poly malic acid / chitosan nano drug sustained-release microcapsule is 10:2.5:(3-5). The preparation method comprises the step of preparing the beta-poly malic acid / chitosan nano drug sustained-release microcapsule from beta-poly malic acid, chitosan and the medicine by utilizing a polyelectrolyte self-assembly principle. The beta-poly malic acid / chitosan nano drug sustained-release microcapsule prepared by the preparation method disclosed by the invention has the advantages of homogeneous granularity, good stability, good sustained release effect and no damage to a human body; and the preparation method disclosed by the invention is simple, mild in conditions and suitable for industrial production.

Description

technical field [0001] The invention relates to the application field of polymalic acid, in particular to β-polymalic acid / chitosan nano medicine slow-release microcapsules prepared by using polymalic acid and chitosan as wall materials and a preparation method thereof. Background technique [0002] β-Polymalic acid (β-Polymalic acid, β-polymalic acid) is an anionic polymer formed by the polymerization of L-malic acid through -COOH and -OH. β-polymalic acid is a biopolymer material that can be excreted through biodegradation without toxic side effects. Because of its easy modification, it can be polymerized with small molecules and used as a drug carrier. At the same time, polymalic acid has a large number of free carboxyl groups, and gelatin, which is negatively charged and positively charged, undergoes complex coagulation to form microcapsules. It can be applied to medicines to improve the efficacy of medicines and reduce toxic and side effects, and can also be used as em...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/36
Inventor 马霞吴艳丽
Owner SHANGHAI INST OF TECH
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