A kind of block copolymer, its preparation method and hydrogel

A technology of block copolymer and hydrogel, applied in the field of block copolymer, its preparation method and hydrogel, can solve the problem that injectable hydrogel does not have electroactivity and the like, achieve good electrochemical response characteristics, Good water solubility

Active Publication Date: 2014-10-22
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the injectable hydrogels prepared by the prior art is electroactive

Method used

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  • A kind of block copolymer, its preparation method and hydrogel
  • A kind of block copolymer, its preparation method and hydrogel
  • A kind of block copolymer, its preparation method and hydrogel

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preparation example Construction

[0052] The present invention also provides a kind of preparation method of block copolymer, comprises the following steps:

[0053] A) Polyethylene glycol or polyethylene glycol monomethyl ether is mixed with lactide and a catalyst for ring-opening polymerization to obtain a block copolymer intermediate, and the lactide is L-lactide or D-lactide - lactide;

[0054] B) mixing the block copolymer intermediate obtained in step A) with a coupling reagent and a compound having the structure of formula (V), and undergoing a condensation reaction to obtain a block copolymer;

[0055]

[0056] in,

[0057] x is the degree of polymerization, 2≤x≤5.

[0058] Preferably, x is 3 or 4.

[0059] First, polyethylene glycol or polyethylene glycol monomethyl ether is mixed with lactide and a catalyst to carry out ring-opening polymerization.

[0060] In the present invention, the polyethylene glycol or polyethylene glycol monomethyl ether is used as the initiator of lactide ring-opening p...

Embodiment 1

[0114] Dissolve 3.68g (0.02mol) of N-phenyl-1,4-p-phenylenediamine in a mixture of 100mL acetone, 100mL water and 25mL concentrated hydrochloric acid to obtain N-phenyl-1,4-p-phenylenediamine mixed solution, and frozen to 0°C; then weighed 4.56g (0.02mol) of ammonium persulfate (APS) and dissolved it in 50mL of 1mol / L HCl aqueous solution to obtain an APS solution, and slowly dropped the APS solution into N-phenyl-1 , in the 4-p-phenylenediamine mixture (dropped in about half an hour), reacted for 3 hours after dropping, then filtered to obtain a solid, and then washed the solid with 0.6mol / L HCl aqueous solution and acetone, and filtered with 0.5mol / L The solid was back-doped with L ammonia water, and finally the solid was washed three times with water to neutrality, freeze-dried and then vacuum-dried to obtain aniline tetramers whose terminal groups were amino groups. The yield was 80%.

Embodiment 2

[0116]Dissolve 3.5g of N-(4-anilino)-1,4-p-phenylenediamine and 2.6g of N,N-diphenyl-1,4-p-phenylenediamine in 100mL N,N-dimethylformaldehyde A mixture of N-(4-anilino)-1,4-p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine was obtained from a mixture of amide, 15mL water and 15mL concentrated hydrochloric acid, and freeze to 0°C; then weigh 2.28 g (0.01 mol) of ammonium persulfate APS and dissolve it in 50 mL of 1 mol / L HCl aqueous solution to obtain an APS solution, slowly drop the APS solution into N-(4-anilino)-1 , in the mixture of 4-p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine (dropped in about half an hour), react for 1 hour after dropping, and then pour the product into 700mL of water for Precipitate, filter to obtain a solid, wash the solid three times with 0.1mol / L HCl aqueous solution and water successively, then back-dope the solid with 0.1mol / L ammonia water, and finally wash the solid three times with water once until neutral, freeze-dry and...

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Abstract

The invention provides a segmented copolymer which comprises a segment A with a structure shown in a formula (I) or a formula (II) and a segment B with a structure shown in a formula (III) or a formula (IV). A laevo-configuration segmented copolymer and a dextro-configuration segmented copolymer are mixed in a water-based medium, and can be gradually transformed into a three-dimensional compound hydrogel material from a solution. Because the segment with the structure shown in the formula (III) or the formula (IV) contains an aniline oligomer segment, the segment B has a intermolecular pi-pi acting force and conjugated pi electrons have conductivity, the prepared segmented copolymer and the hydrogel have better electrochemical response characteristics; and meanwhile, the segment A is extremely dissolved in water, a packaged micelle formed by the segment A and the segment B under a certain linkage quantity can be dissolved in water. Therefore, the segmented copolymer and hydrogel provided by the invention have better water-solubility.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a block copolymer, its preparation method and hydrogel. Background technique [0002] Injectable hydrogel is a type of polymer with a cross-linked network structure that can absorb and retain a large amount of water. This type of material can be cross-linked based on physical forces, such as hydrophobic interaction, electrostatic composite, three-dimensional composite, hydrogen bond interaction, etc. , can also be cross-linked based on chemical reactions, such as Michael addition, photocross-linking, cycloaddition, oxidative coupling, enzyme cross-linking, etc., and then solution-gel transition occurs, so in regenerative medicine and drug controlled release, etc. It has a wide range of uses and is a new research direction in the field of biomedical materials in recent years. Because of its good fluidity, convenient use, long residence time, small wound, performance si...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/91C08G63/664C08J3/075
Inventor 陈学思崔海涛刘亚栋庄秀丽
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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