Albendazole nanoemulsion and preparation method thereof

A technology of albendazole and nanoemulsion, which is applied in the directions of emulsion delivery, oil/fat/wax inactive ingredients, anti-infective drugs, etc., can solve the problem of large dosage error, complicated production process, and influence on insect repellent effect. and other problems, to achieve the effect of easy storage, good transmembrane absorption and less pain

Inactive Publication Date: 2013-03-20
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But albendazole tablet is inconvenient to administer, and side effect is bigger, and manufacturing process is complicated, and price is higher, and albendazole suspension and conventional emulsion are poor in stability, causes dosage error bigger and influences deworming effect

Method used

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  • Albendazole nanoemulsion and preparation method thereof
  • Albendazole nanoemulsion and preparation method thereof
  • Albendazole nanoemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription: Albendazole 0.2g, RH-40 3.5g, glacial acetic acid 1.0g, IPM 0.4g, distilled water 5.0g.

[0025] The specific operation steps are:

[0026] 1) Weigh albendazole, RH-40, glacial acetic acid, IPM, and distilled water according to the prescription quantity for later use;

[0027] 2) Dissolve albendazole completely in glacial acetic acid, then add RH-40 and IPM and mix well, set aside;

[0028] 3) Slowly add the above-mentioned distilled water to the system prepared in step 2) at room temperature, while stirring continuously until a uniform and transparent system is formed, that is, an albendazole nanoemulsion preparation with a particle size of 1-100 nm and a transparent appearance is prepared .

Embodiment 2

[0030] Prescription: Albendazole 0.1 g, Tween-80 3.0 g, glacial acetic acid 0.8 g, ethyl acetate 0.3 g, distilled water 4.0 g.

[0031] The specific operation steps are:

[0032] 1) Weigh albendazole, Tween-80, glacial acetic acid, ethyl acetate and distilled water respectively according to the prescription quantity;

[0033] 2) Dissolve albendazole completely in glacial acetic acid, then add Tween-80 and ethyl acetate and mix well, set aside;

[0034] 3) Slowly add the above-mentioned distilled water to the system prepared in step 2) at room temperature, while stirring continuously until a uniform and transparent system is formed, that is, an albendazole nanoemulsion preparation with a particle size of 1-100 nm and a transparent appearance is prepared .

Embodiment 3

[0036] Prescription: RH-40 2.5 g, PG 0.83 g, glacial acetic acid 0.035 g, albendazole 0.005 g, IPM 0.15 g, distilled water 3.0 g.

[0037] The specific operation steps are:

[0038] 1) Weigh albendazole, RH-40, PG, glacial acetic acid, IPM, and distilled water according to the prescription quantity;

[0039] 2) Dissolve albendazole completely in glacial acetic acid, then add RH-40, PG and IPM and mix well, set aside;

[0040] 3) Slowly add the above-mentioned distilled water to the system prepared in step 2) at room temperature, while stirring continuously until a uniform and transparent system is formed, that is, an albendazole nanoemulsion preparation with a particle size of 1-100 nm and a transparent appearance is prepared .

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Abstract

The invention belongs to the field of veterinary medicines, and discloses an albendazole nanoemulsion and a preparation method thereof. The albendazole nanoemulsion is prepared from the following raw materials by weight: 0.07-2.0% of albendazole, 31.8-38.3% of a surfactant, 0-12.7% of a cosurfactant, 0.54-9.9% of a solubilizer, 2.3-4.0% of oil, and 46.0-49.5% of water. The albendazole is completely dissolved in the solubilizer, and then the surfactant is added. The cosurfactant and the oil are mixed for using. Water is added to the solution prepared by the above steps at room temperature, while the solution is stirred constantly until the formation of a uniform and transparent system. The albendazole nanoemulsion is obtained. Compared with the prior art, the nanoemulsion of the present invention has the following advantages: 1) safety, efficiency and low drug resistance; 2) good stability, filtration sterilization, and easy storage; 3) rapid absorption, high bioavailability, targeted drug delivery, low side effects, small and uniform particle size, and good through-membrane absorption; 4) low-viscosity nanoemulsion, and little injection pain; and 5) easy use, and infinite dilution with water.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a new dosage form of an antiparasitic drug, in particular to an albendazole nanoemulsion and a preparation method thereof. Background technique [0002] Animal parasite infection, especially livestock infection, not only caused serious damage to the breeding industry, but also caused potential harm to consumers from the perspective of food animal safety, thus restricting the development of animal husbandry to a certain extent. Albendazole has broad-spectrum and low toxicity. It is a broad-spectrum specific drug for expelling internal parasites and is widely used clinically. Albendazole bulk drug is insoluble in water, and the dosage forms used clinically are tablets, suspensions and conventional emulsions. But albendazole tablet is inconvenient to administer, and side effect is bigger, and manufacturing process is complicated, and price is higher, and albendazole suspension and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/4184A61K47/34A61K47/44A61P33/00
Inventor 胡帅樊楠李坤鹏
Owner HENAN SOAR VETERINARY PHARMA
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