Preparation method of novel high-strength micro-gel composite hydrogel

Abstract

The invention discloses a preparation method of a novel high-strength micro-gel composite hydrogel. According to the invention, acrylamide and 2-acrylamide-dimethylpropane sulfonic acid are adopted as main monomers; N-methylol acrylamide is adopted as a functional monomer; reactive micro-gel containing hydroxymethyl is obtained through inverse emulsion polymerization; the micro-gel particles are dispersed into the water solution of acrylamide and 2-acrylamide-dimethylpropane sulfonic acid, and free radical polymerization is carried out, such that a micro-gel composite polymer is obtained; and the micro-gel composite polymer or a partially dehydrated micro-gel composite polymer is heated and is subjected to cross-linking, such that the micro-gel composite hydrogel is obtained. According to the invention, nano-clay is adopted as the cross-linking agent. The prepared composite hydrogel has higher mechanical strength, and high water absorption rate. The strength and water content of the hydrogel are similar to those of human cartilage tissues. Therefore, the hydrogel is an alternative material for cartilage tissue reparation.

Description

technical field

[0001] The invention relates to a preparation method of a hydrogel, in particular to a preparation method of a high-strength gel composite novel hydrogel. Background technique

[0002] Gels (gels) refer to polymers with a three-dimensional network structure and their swelling bodies that are insoluble in any solvent. They are soft and moist and look like solid materials, but they can deform with changes in the environment.

[0003] This is very different from dry hard materials such as traditional steel and plastic. Gels can be divided into three types according to the solvent contained

[0004] Classes: Hydrogels with water as solvent, lipogels with non-aqueous organic substances as solvent, and aerogels. Among them, hydrogels are the most common.

[0005] Hydrogel is a three-dimensional network polymer formed by cross-linking linear polymer chains, which can swell in water and retain a large amount of water without dissolving. Because the molecular stru...