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Patch for heroin addiction withdrawal, preparation method and application thereof

A heroin and patch technology, which is applied in the field of drugs for withdrawal from heroin addiction, can solve the problems of long treatment period and high cost

Active Publication Date: 2013-04-03
ZHAOQING XINFENG ECO FRIENDLY MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, naltrexone hydrochloride is used to quit heroin addiction. The commonly used methods are subcutaneous implantation of drugs or oral administration. These methods have a long treatment period and high cost

Method used

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  • Patch for heroin addiction withdrawal, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Preparation of patch

[0053] Stir the acrylate copolymer and naltrexone hydrochloride evenly at a weight ratio of 35:65 to obtain a drug mixed solution, coat the drug mixed solution on the PE backing layer, dry it, and then laminate it with the PE protective layer, separate Cut to obtain patches, the weight of naltrexone hydrochloride in each patch is 16±1mg / pcs.

[0054] Wherein, the preparation method of acrylate copolymer is

[0055] Recipe: 35g acrylic acid, 0.25g crosslinking agent

[0056] Butyl acrylate 10g emulsifier 0.15g

[0057] Styrene 25 tackifier 2.0g

[0058] Vinyl acetate 10g Acetone 20g

[0059] Preparation method: Add deionized water and emulsifier into the reaction kettle with stirrer, thermometer, reflux condenser and dripping device, stir and heat when the temperature rises to 75°C, add initiator aqueous solution, and drop acrylic acid, A mixed monomer of butyl acrylate, styrene and vinyl acetate. The dropwise addition was c...

Embodiment 2

[0069] Take 45 parts by weight of the film slow-release carrier A and 55 parts by weight of naltrexone hydrochloride and mix them, stir evenly to obtain a drug mixed solution, coat the drug mixed solution on the PE backing layer, dry it, and then laminate it with the PE protective layer , cut to obtain a patch, and the weight of naltrexone hydrochloride in each patch is 16 mg.

Embodiment 3

[0071] Take 70 parts by weight of the film slow-release carrier B and 30 parts by weight of naltrexone hydrochloride, mix them, stir them evenly, and obtain a drug mixed solution, coat the drug mixed solution on the PE backing layer, dry it, and then laminate it with the PE protective layer , cut to obtain a patch, and the weight of naltrexone hydrochloride in each patch is 16 mg.

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PUM

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Abstract

The invention discloses a patch for heroin addiction withdrawal, a preparation method and an application thereof. The patch for heroin addiction withdrawal of the invention comprises a backing layer, a substrate layer, and a protection layer; the substrate layer of the patch comprises a main drug effective component of naltrexone hydrochloride, wherein naltrexone hydrochloride accounts for 30-55 wt% of the substrate layer; the substrate layer comprises 45-70 wt% of a film forming slow release carrier; the slow release carrier is acrylate copolymer. The patch for heroin addiction withdrawal of the invention is used for pasting on human body abdominal navel, adopts a mechanism method of percutaneous forced automatic drug administration, employs a therapy of psychological dependence resistance, has no side effect, and allows patients to work and study as normal people during detoxification process.

Description

technical field [0001] The invention relates to a drug for withdrawal from heroin addiction, in particular to a patch for withdrawal from heroin addiction, a preparation method and application thereof. Background technique [0002] Drug abuse has become a public hazard in the world. The annual global drug trade volume has exceeded one trillion US dollars, which is equivalent to the global arms trade volume and higher than the income of the global oil and gas industry. At present, China has officially announced that in 2005, 298,000 people underwent compulsory drug rehabilitation and 70,000 people were rehabilitated through labor camps. The number of registered drug addicts in the country has reached 1.16 million. Based on the statistics of 0.3 grams of heroin per person per day, the direct consumption of drug funds has reached nearly 200 billion yuan. The loss of labor force of drug-related personnel, the destruction of their families, the deterioration of social crimes, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/485A61K47/32A61P25/36
Inventor 钟国敏
Owner ZHAOQING XINFENG ECO FRIENDLY MATERIAL
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