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Preparation method of drug capable of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pains

A technology for promoting qi and relieving pain, promoting blood circulation and removing blood stasis, which is applied in the direction of drug combinations, pharmaceutical formulas, non-central analgesics, etc. It can solve the problems of affecting quality stability, slow dissolution rate of active ingredients, and low crushing fineness, and achieves improved Stability, improve bioavailability, reduce the effect of production energy consumption

Inactive Publication Date: 2013-04-03
泸州百草堂中药饮片有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the production and use for many years, the inventor found that the above-mentioned traditional technology has the following defects: 1. The extraction rate of active ingredients is low, and the recovery rate of active ingredients in the original process is generally 45-60%; 2. High energy consumption; 3. The bioavailability is low, especially the medicinal materials used as raw powder. Due to the low grinding fineness, the dissolution rate of the active ingredients is slow, which affects the curative effect and the utilization rate of the active ingredients.
4. Capsule contents (granules) are prone to moisture, which affects the stability of quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 The preparation method of Xinkeshu capsule of the present invention

[0016] (1) Weigh the API according to the following prescription:

[0017] Hawthorn 375g, Danshen 375g, Pueraria 375g, Panax notoginseng 25g, Muxiang 25g;

[0018] (2) For the above five flavors, take Panax notoginseng and woody fragrance and grind them into 500-mesh superfine powder; hawthorn and pueraria root into 8-14 meshes, add 60% ethanol for 30 minutes, heat and reflux for extraction twice, the first time for 2.5 hours , for the second 2 hours, combine the ethanol extracts, recover the ethanol under reduced pressure, concentrate to a relative density of 1.35 (20°C); grind the salvia miltiorrhiza into coarse powder, add water at 60-80°C to extract twice, the first time for 2 hours, the second After 1.5 hours, combine the water extracts, filter, and concentrate the filtrate to a relative density of 1.35 (20°C); dry the above two thick pastes at 80°C, grind them into fine powders, mi...

Embodiment 2

[0020] Embodiment 2 The preparation method of Xinkeshu capsules of the present invention

[0021] (1) Weigh the API according to the following prescription:

[0022] Hawthorn 375g, Danshen 375g, Pueraria 375g, Panax notoginseng 25g, Muxiang 25g;

[0023] (2) For the above five flavors, take Panax notoginseng and woody fragrance and grind them into 500-mesh superfine powder; hawthorn and pueraria root into 8-14 meshes, add 60% ethanol for 30 minutes, heat and reflux for extraction twice, the first time for 2.5 hours , for the second 2 hours, combine the ethanol extracts, recover the ethanol under reduced pressure, concentrate to a relative density of 1.35 (20°C); grind the salvia miltiorrhiza into coarse powder, add water at 60-80°C to extract twice, the first time for 2 hours, the second After 1.5 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.35 (20°C); dry the above two thick pastes at 80°C, grind them into fine powder and mix ...

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Abstract

The invention provides a preparation method of a drug capable of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pains. The preparation method fully reserves effective components of raw drug materials medicinal, effectively improves biological availability of the drugs, increases stability of preparations, reduces production energy consumption, and provides better method for preparing Xinkeshu capsules.

Description

technical field [0001] The invention relates to a preparation method of a drug for promoting blood circulation, removing blood stasis, promoting qi and relieving pain. The invention mainly relates to a new preparation method of Xinkeshu capsule. Background technique [0002] Xinkeshu capsule is a pure natural plant compound preparation, which was first recorded in the fifteenth volume of traditional Chinese medicine preparations in the "Drug Standards" of the Ministry of Health of the People's Republic of China. It is made of Danshen, Pueraria root, Panax notoginseng, hawthorn, and woody incense, which promotes blood circulation and removes blood stasis, promotes qi and relieves pain. It is used for chest tightness, angina pectoris, dizziness, headache, neck pain, arrhythmia and hyperlipidemia caused by qi stagnation and blood stasis type coronary heart disease. The drug is taken orally, 4 capsules at a time, 3 times a day. [0003] At present, the preparation method of X...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/48A61P9/10A61P9/06A61P3/06A61P29/00
Inventor 高庆凌张显胡俊刚
Owner 泸州百草堂中药饮片有限公司
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