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Chinese herbal soft capsules for treating primary hypotension and preparation method of soft capsules

A technology for primary hypotension and soft capsules, applied in the directions of capsule delivery, pharmaceutical formulations, cardiovascular system diseases, etc., can solve problems such as unsatisfactory effects of Chinese patent medicines, and achieve the effect of significant technological progress

Inactive Publication Date: 2013-04-03
陕西步长高新制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] For this reason, we have applied for the following 3 invention patents for this traditional Chinese medicine composition, the publication numbers of which are CN1471928A, CN1733027A and CN1733257A respectively, and the publication dates are 2006.01.04, 2006.02.15 and 2006.02.15 respectively. The above invention patent documents It is disclosed and protected from the aspects of different component dosage, preparation process, quality control method and dosage form in the prescription, but in the actual application process, we found that the effect of the Chinese patent medicine made by the above preparation method is not ideal, and The patent of this application is to further optimize the preparation process method through a large number of experiments, and find the best preparation process parameters, the pharmacological experiment effect is more significant, and the purpose of improving the stability and bioavailability of the preparation, and the creative development is successful. A traditional Chinese medicine soft capsule for treating essential hypotension

Method used

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  • Chinese herbal soft capsules for treating primary hypotension and preparation method of soft capsules
  • Chinese herbal soft capsules for treating primary hypotension and preparation method of soft capsules
  • Chinese herbal soft capsules for treating primary hypotension and preparation method of soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] ⑴Take 12g donkey-hide gelatin and 32g Gastrodia elata and crush them into coarse powder, then ultrafinely pulverize them into fine powder, sieve, and set aside;

[0065] (2) Take 120g of red ginseng, 540g of agrimony, 300g of Radix Ophiopogon japonicus, 400g of terrazzo vine, reflux extraction with 8 times the amount of 70% ethanol for 2 times, each time for 2 hours, filter, combine the filtrate and recover the ethanol until there is no alcohol smell. The liquid is concentrated and dried and crushed into a dry cream powder, sieved, and the dregs are set aside;

[0066](3) Take 360g of Citrus aurantium, 300g of Guizhi, and 180g of Ephedra, add water with a weight ratio of 10 times that of the medicinal materials, soak for 1 hour, steam distill for 2 hours, collect the volatile oil, distill the aqueous solution, filter, and use the filtrate and medicinal residues for later use;

[0067] (4) Combine the dregs of (2) and (3) with 300g of Rehmannia glutinosa, add water with ...

Embodiment 2

[0070] ⑴Take 12g donkey-hide gelatin and 32g Gastrodia elata and crush them into coarse powder, then ultrafinely pulverize them into fine powder, sieve, and set aside;

[0071] (2) Take 120g of red ginseng, 540g of agrimony, 300g of Radix Ophiopogon japonicus, 400g of terrazzo vine, reflux extraction with 7 times the amount of 60% ethanol for 1 time, 3 hours each time, filter, combine the filtrate and recover the ethanol until there is no alcohol smell, and then use the medicine The liquid is concentrated and dried and crushed into a dry cream powder, sieved, and the dregs are set aside;

[0072] (3) Take 360g of Citrus aurantium, 300g of Guizhi, and 180g of Ephedra, add water with a weight ratio of 12 times that of the medicinal materials, soak for 1 hour, steam distill for 1 hour, collect the volatile oil, distill the aqueous solution, filter, and use the filtrate and medicinal residue for later use;

[0073] (4) Combine the dregs of (2) and (3) with 300g of Rehmannia gluti...

Embodiment 3

[0076] ⑴Take 12g donkey-hide gelatin and 32g Gastrodia elata and crush them into coarse powder, then ultrafinely pulverize them into fine powder, sieve, and set aside;

[0077] (2) Take 120g of red ginseng, 540g of agrimony, 300g of Ophiopogon japonicus, 400g of terrazzo vine, reflux extraction with 10 times the amount of 80% ethanol for 3 times, each time for 1 hour, filter, combine the filtrate and recover the ethanol until there is no alcohol smell, Concentrate and dry the liquid medicine and crush it into a dry cream powder, sieve, and leave the medicine residue for later use;

[0078] (3) Take 360g of Citrus aurantium, 300g of Guizhi, and 180g of Ephedra, add water with a weight ratio of 8 times that of the medicinal materials, soak for 1 hour, steam distill for 3 hours, collect the volatile oil, distill the aqueous solution, filter, and use the filtrate and medicinal residue for later use;

[0079] (4) Combine the dregs of (2) and (3) with 300g of Rehmannia glutinosa, a...

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Abstract

The invention relates to Chinese herbal soft capsules for treating primary hypotension and a preparation method of the soft capsules. The Chinese herbal soft capsules are prepared from the following raw materials in parts by weight: 120 parts of red ginseng, 360 parts of immature bitter orange, 180 parts of ephedrine, 300 parts of cassia twig, 300 parts of prepared rehmannia root, 300 parts of radix ophiopogonis, 400 parts of Chinese starjasmine stem, 540 parts of hairyvein agrimony, 12 parts of donkey-hide gelatin and 32 parts of gastrodia elata. The preparation method of the Chinese herbal soft capsules comprises the steps of performing extraction and purification on the raw materials according to a certain technique, and then mixing the materials with auxiliary materials which are acceptable in pharmaceutics. The Chinese herbal soft capsules provided by the invention have the characteristics of adopting the simple and feasible preparation technique, being safe and effective, and having remarkable pharmacologic and pharmacodynamic effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine soft capsule for treating essential hypotension and a preparation method thereof, belonging to the technical field of medicine preparation. Background technique [0002] Hypotension is a common and frequently-occurring disease that occurs widely all over the world. According to incomplete statistics, the incidence of hypotension is about 4%, and it can reach 10% in the elderly population. Patients suffer from hypotension for a long time, which can lead to a great decline in body function, and may also lead to cerebral infarction and myocardial infarction. The mortality rate of hypotensive people is also higher than that of normal people, which has brought serious problems to patients, families and society, which cannot be ignored . At present, there is no particularly effective treatment method in this field for the treatment of such diseases. Patients take Western medicine for a long time for ...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/48A61P9/02
Inventor 赵步长赵超
Owner 陕西步长高新制药有限公司
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