Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Active xanthone compound and preparation method thereof

A compound, the technology of ketone, which is applied in the field of active ketone compound and its preparation, can solve the problems of low yield and few applications

Inactive Publication Date: 2013-04-03
ZHONGBEI UNIV
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] One-step synthesis method refers to the formation of ether bond and carbonyl group through one-step reaction. This method is simple and easy to operate, but this method is relatively seldom used
That is to use o-hydroxybenzoic acid and phenolic compounds as raw materials to complete the synthesis of the ketone mother nucleus in the next step under the action of polyphosphoric acid or phosphorus oxychloride, but the yield is low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Active xanthone compound and preparation method thereof
  • Active xanthone compound and preparation method thereof
  • Active xanthone compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 10.913g o-aminophenol into a three-necked flask, add 100mL concentrated HCl and 100mL water, cool in an ice-salt bath, and dissolve 7gNaNO 2 and 50mL of water, move the prepared sodium nitrite solution into a constant pressure dropping funnel, slowly drop it into a three-necked bottle, stir mechanically, and control the temperature below 5°C with the dropping speed. After the dropwise addition, 0.2mol of KI solution was added dropwise under vigorous stirring, and a large amount of foam (N 2 ), heated in a water bath at 50°C after the addition, and cooled. Then extract with an appropriate amount of ether, using Na 2 S 2 o 3 Solution washing, washing with water, with anhydrous MgSO 4 After drying, one-step intermediate o-iodophenol is obtained.

[0033] Add 100ml of toluene into the three-necked flask as a solvent, then add 22.03g of the one-step intermediate and 25.2g of phloroglucinol, and add the dehydrating agent POCl into the three-necked flask equipped wi...

Embodiment 2

[0037] Antibacterial activity experiments were carried out on the target compound 2,4-dihydroxykoushanone. Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli were selected as indicator bacteria, and gentamicin sulfate was used as reference sample. Experiments show that: 2,4-dihydroxykoushanone has a certain antibacterial effect on Escherichia coli, and has a very good antibacterial effect on Staphylococcus aureus.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an active xanthone compound, which has a structure represented by a general formula (I) as follows. 2,4-dihydroxyl xanthones differing in concentration represent different degrees of antibacterial effects on staphylococcus aureus, therefore the active xanthone compound has a remarkable inhibiting effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical compounds, in particular to an active ketone compound with antibacterial effect and a preparation method thereof. Background technique [0002] Koshanone is also called dibenzo-γ-pyrone, xanthone, xanthone, etc. It is a substance that has a stronger antioxidant effect than vitamin C and vitamin E. It has heat-clearing, detoxifying, anti-inflammatory, Liver protection, choleretic, diuretic, antibacterial, anticancer, antimalarial, antidepressant, antioxidative and other physiological activities, its derivatives are widely distributed in nature, and are one of the active ingredients of medicinal plants, with high medicinal value . Scutellaria baicalensis of the family Gentianaceae, which is rich in ketones, is a common folk medicine of the Naxi, Tibetan, and Miao nationalities. Polygala urophylla mainly distributed in southwest my country is rich in ketones, and its roots are used as medicine in the f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/86A61P31/04
Inventor 马雪梅郑志花李志春潘婕李红鹏
Owner ZHONGBEI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com