Rapid phototoxicity experiment equipment with simultaneous exposure of multiple point positions

Abstract

The invention provides rapid phototoxicity experiment equipment with simultaneous exposure of multiple point positions. The equipment comprises a light-absorbing surface operating console, a main control instrument plate with a camera, and a light path box supported by an altitude controller, wherein experimental animals are placed in the middle of the light-absorbing surface operating console; a UVA (ultraviolet A) powerful light source of the light path box adopts high-voltage strong-light halide lamp as a UVA pure light source, an experimental region and an experimental area of the experimental animals are adjustable, and laser is used for locating and position calibration. In an experiment, a foot pedal control circuit is stepped so as to start the UVA powerful light source in the light path box, and under the feedback of a UVA light intensity measurer and the control of the control circuit, the UVA powerful light source is switched on and appropriately delayed, so that enough UVA light rays simultaneously and electrically irradiate on multiple points of back skins of the experimental animals to implement a rapid phototoxicity exposure test. The equipment provided by the invention has the beneficial effects that the UVA powerful light source is adopted for implementing the exposure and irradiation of the multiple point positions simultaneously, so that the speed is high, and the consistency is good; the localization of the experimental animals is exact, experimental data are accurate, and the pollution caused by operating staff can be avoided; and the experimental equipment can be widely applied to scientific researches in the fields of chemical industry, labor and occupational protection, medicines and the like.

Description

technical field [0001] The invention provides a multi-point simultaneous exposure rapid phototoxicity experiment equipment. Background technique [0002] Phototoxicity refers to a skin toxic reaction caused by exposure to ultraviolet radiation after the skin is exposed to chemical substances. The phototoxicity test is to apply a certain amount of the test substance on the dehaired skin of the back of the animal, and after a certain time interval Exposure to UVA light with a wavelength in the range of 320-400 nanometers to simulate sunlight irradiation experiments, observe whether the skin of the tested animals has thick, red, swollen, macule, blisters and other adverse reactions after a certain dose of UVA light irradiation, and follow the relevant The specified standards are compared to determine whether the test substance is phototoxic to animals, so as to deduce whether it may cause phototoxic damage to humans. In the past, the phototoxicity experiment equipment used ord...

AI Technical Summary

Problems solved by technology

In the past, the phototoxicity experiment equipment used ordinary UV light source or point light source. Because the light intensity of ordinary UV light source is low, the experimental irradiation time is long, and the light source will produce thermal effect, which will increase the temperature of the irradiation field and make animals feel uncomfortable. Comfortable and free from shackles to move, the position of the irradiation will also move and dislocate, which will affect the experimental results, so the experimental operators will be exposed to ultraviolet rays and will be hurt; the point light source has high light intensity but can only be irradiated at a single point. Although the irradiation time is short, the experiment time The overall time is long and the efficiency is low, and the animals are not easy to be restrained. Therefore, it is urgent to develop and design a multi-point simultaneous exposure rapid phototoxicity equipment.

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