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Method for repairing demineralized dentin

An essential, mineral-based technology, used in dentistry, dental preparations, dental prostheses, etc., to achieve the effects of easy availability of raw materials, recovery of mineral content, and recovery of super mechanical properties

Inactive Publication Date: 2013-04-10
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Method for repairing demineralized dentin
  • Method for repairing demineralized dentin
  • Method for repairing demineralized dentin

Examples

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Embodiment 1

[0023] Equipped with 0.25M calcium chloride (CaCl 2 ) aqueous solution, 0.15M disodium hydrogen phosphate (Na 2 HPO 4 ) aqueous solution, 10g / L polyacrylic acid (PAA) aqueous solution was used as the mother liquor for the synthesis experiment. Take 2.4 mL of Na 2 HPO 4 Mix the mother liquor and 2.0mL of PAA mother liquor, dilute with twice distilled water, adjust the pH to 9.5±0.1 with 1M NaOH aqueous solution, stir at room temperature for 0.5h, and the total volume is 30mL. Take 2.4mL CaCl 2 Dilute the mother liquor with water to 30mL. Use a burette to add 30mL of calcium solution 30 to 30mL of phosphorus solution, stir with a magnetic stirrer during the dropwise addition, and adjust the pH with 0.1M NaOH solution to keep it in the range of 9.5±0.5. Finally, the calcium ion concentration was 10.0mM, the phosphorus ion concentration was 6.0mM, and the PAA concentration was 300ug / mL. Ensure that the entire dropping process lasts for 25 to 30 minutes. To collect caries-...

Embodiment 2

[0025] Equipped with 0.25M calcium chloride (CaCl 2 ) aqueous solution, 0.15M disodium hydrogen phosphate (Na 2 HPO 4 ) aqueous solution, 10g / L polyacrylic acid (PAA) aqueous solution was used as the mother liquor for the synthesis experiment. Take 2.4 mL of Na 2 HPO 4 Mix the mother liquor with 3.0mL of PAA mother liquor, dilute with double distilled water, adjust the pH to 9.5±0.1 with 1M NaOH aqueous solution, stir at room temperature for 0.5h, and the total volume is 30mL. Take 2.4mL CaCl 2 Dilute the mother liquor with water to 30mL. Use a burette to add 30 mL of calcium solution 30 to 30 mL of phosphorus solution, stir with a magnetic stirrer during the dropwise addition, and keep the pH in the range of 9.5±0.5 by adjusting the pH with 0.1M NaOH solution. Finally, the calcium ion concentration was 10.0 mM, the phosphorus ion concentration was 6.0 mM, and the PAA concentration was 500 ug / mL. Ensure that the entire dropping process lasts for 25 to 30 minutes. To co...

Embodiment 3

[0027] Equipped with 0.25M calcium chloride (CaCl 2 ) aqueous solution, 0.15M disodium hydrogen phosphate (Na 2 HPO 4 ) aqueous solution, 10g / L polyacrylic acid (PAA) aqueous solution was used as the mother liquor for the synthesis experiment. Take 2.4 mL of Na 2 HPO 4 Mix the mother liquor with 6.0mL of PAA mother liquor, dilute with twice distilled water, adjust the pH to 9.5±0.1 with 1M NaOH aqueous solution, stir at room temperature for 0.5 h, and the total volume is 30 mL. Take 2.4mL CaCl 2Dilute the mother liquor with water to 30mL. Use a burette to add 30 mL of calcium solution 30 to 30 mL of phosphorus solution, stir with a magnetic stirrer during the dropwise addition, and keep the pH in the range of 9.5±0.5 with 0.1M NaOH solution. The final concentrations of calcium ions and phosphorus ions were 10.0 mM and 6.0 mM, respectively. Finally, the calcium ion concentration was 10.0 mM, the phosphorus ion concentration was 6.0 mM, and the PAA concentration was 1000...

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Abstract

The invention relates to a method for repairing demineralized dentin. A conventional method for repairing demineralized dentin is realized through adopting two dentin non-collagenous protein analogues and having the aid of a portland cement sustained-release system, however, the time required to achieve the whole layer mineralization needs to last four months because the conventional method is excessively complicated. The method comprises the following steps: at first, simple, convenient and readily available polyacrylic acid is taken as a conditioning agent, and calcium ions and phosphonium ions are taken as raw materials, so as to synthetize amorphous calcium phosphate particles with the size of 15 to 20 nm and flowability; and then, the demineralized dentin is remineralized within 7 days to recover the natural hierarchical organization of the demineralized dentin, and the mechanical property of the remineralized dentin reaches the same level with that of the natural dentin. Compared with the conventional remineralization technology, on the basis of reaching the same repaired hierarchical organization and the same mechanical property, the device is simple, the consumed time is short, and the fact that the demineralized dentin is remineraized is more effectively achieved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and relates to a method for repairing demineralized dentin. Background technique [0002] In the process of dentin bonding, acid etching and demineralization of dentin leads to the exposure of collagen fibers, and the degradation of exposed collagen by endogenous matrix metalloproteinases is the key factor that limits the life of the resin-dentin bonding complex. Moderate and deep carious lesions also manifest as demineralization and caries of the dentin layer. Addressing these problems involves remineralization of demineralized dentin. With the enrichment of people's knowledge about the fine structure of dentin and the organic combination of collagen fibers and minerals, the understanding of the role of non-collagen proteins in dentin mineralization and the specific process of biomineralization are gradually understood and simulated in vitro. The field of mineral dentin restoration has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/033A61K6/838
Inventor 顾新华唐睿康陈怡王建明孙健
Owner ZHEJIANG UNIV
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