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Use of inhaled nitrous oxide or xenon for preventing neuropathic pain induced by cancer chemotherapy

A technology for nitrous oxide and cancer, applied in nervous system diseases, non-central analgesics, medical preparations containing active ingredients, etc., can solve the problems not mentioned, and achieve the effect of alleviating the delayed effect

Active Publication Date: 2013-04-17
LAIR LIQUIDE SA POUR LETUDE & LEXPLOITATION DES PROCEDES GEORGES CLAUDE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] However, the document is completely silent on pain resulting from treatment with one or more platinum salts, taxanes or other similar substances of the alkaloid, thalidomide or bortezomib type

Method used

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  • Use of inhaled nitrous oxide or xenon for preventing neuropathic pain induced by cancer chemotherapy
  • Use of inhaled nitrous oxide or xenon for preventing neuropathic pain induced by cancer chemotherapy

Examples

Experimental program
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Embodiment

[0057] figure 1 A diagram showing the oxaliplatin molecule used in experiments as an anticancer substance hereinafter.

[0058] Oxaliplatin is commonly used against cancer, especially rectal and colon cancer, because it inhibits DNA synthesis and replication by forming intrastrand bridges between adjacent guanines, which is particularly useful against this type of cancer is a treatment option. Unfortunately, this molecule has the disadvantage of inducing neuropathic pain in cancer patients to whom it is administered.

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Abstract

The invention relates to a gaseous inhalable medicament containing xenon or N2O as active ingredient for use by inhalation for preventing and / or for treating neuropathic pain or pains caused by at least one cancer chemotherapy substance administered to a patient suffering from cancer, in particular a patient suffering from breast cancer, lung cancer, ovarian cancer, prostate cancer, colon cancer, rectal cancer or a gastric cancer or cancer of the upper aerodigestive tracts. The cancer chemotherapy substance contains one or more compounds chosen from platinum salts, taxanes, alkaloids, thalidomide and bortezomib, in particular paclitaxel, docetaxel or oxaliplatin. The effective volume proportion of nitrous oxide or of xenon is between 5 and 70%.

Description

technical field [0001] The present invention relates to xenon-based or N-based 2 The gas of O is an inhalable composition or medicament for the prophylaxis (ie preventing occurrence) or treatment (ie complete or partial cure), or at least minimization, of neuropathic pain caused by cancer chemotherapeutic substances administered to cancer patients. Background technique [0002] The development of chemotherapy for the treatment of cancer has resulted in dramatic improvements in patient survival and often a return to normal or substantially normal life. [0003] However, cancer chemotherapy is often neurotoxic and often induces considerable complications. [0004] More specifically, neurotoxic side effects affect the peripheral nervous system by targeting neuronal cell bodies, axons, myelin and / or glial cells. This often results in chemotherapy-induced peripheral neuropathy as described by C. Sioka et al., Central and peripheral nervous system toxicity of common chemotherape...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K45/06A61P25/04A61P29/02A61K33/243
CPCA61K45/06A61K31/555A61K33/00A61P23/00A61P25/02A61P25/04A61P29/00A61P29/02A61P35/00A61P39/00A61K33/243A61K2300/00A61K33/24
Inventor B·贝谢雷J·皮普G·西莫内
Owner LAIR LIQUIDE SA POUR LETUDE & LEXPLOITATION DES PROCEDES GEORGES CLAUDE
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