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System and method for monitoring diprivan narcotic drug on line

An anesthetic, propofol technology, applied in the field of propofol anesthetic detection, can solve the problems of patients' physical or mental injury, small safety range, and real-time monitoring of venous blood drug concentration, etc., to achieve efficient anesthesia drug scheme and equipment The effect of support, short monitoring intervals and light weight

Active Publication Date: 2013-04-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the safety range of using this sedative drug in clinical practice is small, and no matter whether the sedation is too deep or too shallow, it will cause corresponding physical or mental harm to the patient, so it is very important to monitor the depth of sedation during anesthesia and sedation
At present, due to the unavailability of real-time monitoring of venous blood drug concentration, it is difficult to determine the depth of sedation completely by intravenous anesthesia

Method used

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  • System and method for monitoring diprivan narcotic drug on line
  • System and method for monitoring diprivan narcotic drug on line
  • System and method for monitoring diprivan narcotic drug on line

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In order to ensure that the sensor will not be polluted by high-concentration propofol, the medical propofol injection (concentration: 10mg / mL) is diluted with methanol to 100ug / mL in the qualitative experiment, and 1mL of the solution of this concentration is taken into a glass bottle of 5mL In, cover and let stand for 10 minutes. When testing, place the system's pumping and sampling needle at 0.5 cm above the liquid surface, and use the virtual sensor array to detect after pumping and sampling for 10 seconds. Figure 4 The spectrum of the system’s single detection of propofol is given. Under the conditions of carrier gas flow of 3mL / min, inlet temperature of 200 degrees Celsius, six-way valve temperature of 165 degrees Celsius, and detector temperature of 30 degrees Celsius, propofol The peak time is (6.93 seconds), indicating that the system of the present invention can perform rapid qualitative detection of propofol.

[0034] In the quantitative experiment, after m...

Embodiment 2

[0037] After the patient enters the room, non-invasive BP, HR, end-tidal CO2, SPO2 and other routine monitoring are performed, and the patient is given pre-oxygenation with a mask 5 minutes before anesthesia induction. The anesthesia induction starts: respiratory anesthesia with sevoflurane 3% concentration, fentanyl 2ug / kg After rocuronium bromide 0.6mg / kg, endotracheal intubation, mechanical ventilation (tidal volume 8mL / kg, frequency 12 breaths / min, respiratory-expiratory ratio 1:2, oxygen concentration 50%), anesthesia maintenance: sevoflurane 4 % concentration, remifentanil 0.5ug / kg / min, inject rocuronium bromide according to the operation requirements. Such as Figure 7 As shown, after induction of anesthesia, insert the gas sampling needle and the temperature monitor of the system of the present invention at the expiratory end of the endotracheal tube to ensure that the exhaled gas brought out by the ventilator is not passed through the gas filter device by the system o...

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Abstract

The invention discloses a system and a method for monitoring a diprivan narcotic drug on line. The system comprises a carrier gas generator, a drying and filtering bottle, a numerical control quality / flow meter, a minitype thermal desorption device, a heating six-way valve, a heating evacuating sample injection needle and a gas pump, wherein an outlet of the carrier gas generator is connected with an inlet of the drying and filtering bottle, and the outlet of the drying and filtering bottle is connected with an inlet of the numerical control quality / flow meter; and six ports of the heating six-way valve are connected with an acoustic surface wave detecting unit, an outlet of the numerical control quality / flow meter, two ends of the minitype thermal desorption device, a gas outlet of the heating evacuating sample injection needle and the gas pump respectively. According to the system and the method, an acoustic surface wave gas sensor arrays coated with different sensitive materials or sensitive parts formed by combination of acoustic surface wave gas sensors free from coating of the sensitive materials and a rapid capillary tube separation technology are adopted, and the trace detection of gas-state diprivan is achieved through the combination of gas flow control; and the detection sensitivity for the diprivan high, the detection limit is low, and the work is safe and stable.

Description

technical field [0001] The invention relates to a new rapid, sensitive, efficient and reliable detection technology of propofol anesthetic, in particular to a system and method for online monitoring of propofol anesthetic during operation. Background technique [0002] Propofol entered clinical trials for the first time in the UK in 1977, and is currently approved in more than 50 countries, and is widely used in clinical anesthesia induction, maintenance and sedation. With the development of comfortable medical care in China, the safety and comfort of anesthesia and sedation are getting more and more attention. Propofol is more and more used in total intravenous anesthesia due to its fast onset of anesthesia, stable induction, short duration, fast and complete recovery, no cough, hiccups, etc., and its annual consumption in China is increasing rapidly every year. However, the safety range of using this sedative drug in clinical practice is small, and no matter whether the s...

Claims

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Application Information

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IPC IPC(8): G01N29/024
Inventor 严敏陈星张冯江王平王镝
Owner ZHEJIANG UNIV
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