Hybrid micro-fluidic chip based on micro/nano structure and preparation method thereof

A microfluidic chip and nanostructure technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve problems such as no substantial breakthroughs, achieve good application prospects, reduce costs, Efficient mixing effect

Inactive Publication Date: 2013-04-24
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The development of a convenient, fast, efficient, and low-cost microfluidic drive and control technology should be one of the research directions for microvalve on microfluidic chips, and there has been no substantial breakthrough yet.

Method used

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  • Hybrid micro-fluidic chip based on micro/nano structure and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The microstructure and microchannel pattern of the two-layer chip of the microfluidic chip with controllable microfluidic flow are designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer polymethyl methacrylate (PMMA) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to make a smart microvalve based on a microfluidic chip. The sample solution is injected into the sample injection hole of the microfluidic chip through two peristaltic pumps. The solution enters the serpentine mixing zone in the microchannel driven by the e...

Embodiment 2

[0021] The microstructure and microchannel graphics of the two-layer chip of the centrifugal microfluidic chip were designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer disc-shaped polycarbonate (PC) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to make a smart microvalve based on a microfluidic chip. The sample solution is injected into the sample injection hole of the microfluidic chip through two peristaltic pumps. The solution enters the serpentine mixing zone in the microchannel driven by the external peristaltic pu...

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Abstract

The invention relates to a hybrid micro-fluidic chip based on a micro / nano structure and a preparation method thereof. A micro-channel and the micro / nano structure are formed on the surface of the micro-fluidic chip; solution is efficiently mixed through the micro / nano structure on the surface of the micro-channel to quickly and efficiently mix micro-fluidic solution; and the hybrid micro-fluidic chip is mainly applied to the relevant fields of biological assay, phase change reaction, multi-component reaction and the like. The micro-fluidic chip and the preparation method thereof have the benefits that the operation is simple, efficient mixing of the micro-fluidic solution is realized, the mixing cost of the micro-fluidic solution is greatly reduced, the micro-fluidic chip has the characteristics of convenience in carrying, economy, quickness and high efficiency, and a brand-new analysis technology is provided for efficient and uniform mixing of the micro-fluidic solution.

Description

technical field [0001] The invention relates to a hybrid microfluidic chip based on a micro / nano structure and a preparation method thereof. The surface of the microfluidic chip has a microchannel and a micro / nano structure, and a solution passes through the micro / nano structure on the surface of the microchannel to generate high-efficiency Mixing, so as to achieve rapid and efficient mixing of microfluidic solutions, mainly used in biological assays, phase change reactions, multi-component reactions and other related fields. Background technique [0002] As a new type of analysis platform, microfluidic analysis chip has the advantages of miniaturization, automation, integration, convenience and speed, and has been widely used in many fields, such as cell biology, analytical chemistry, environmental monitoring and protection, Forensic identification and drug synthesis screening. In microfluidic analysis chips, the uniform mixing of microfluids is the key to sample processin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 聂富强王晓东沙俊叶嘉明
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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