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Nano lipid carrier composition and preparation method thereof

A nano-lipid carrier and composition technology, which is applied in food science, pharmaceutical formulations, cosmetic formulations, etc., can solve problems such as solvent residues, improve particle size and dispersion performance, improve drug-carrying capacity, and increase crystal disorder. Effect

Active Publication Date: 2016-05-25
WILMAR SHANGHAI BIOTECH RES & DEV CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, it is the preparation process. The above three patents such as US20080102127A1 all use organic solvents in the preparation, which puts forward more requirements for the conditions of large-scale production, and there will also be problems such as solvent residues.

Method used

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  • Nano lipid carrier composition and preparation method thereof
  • Nano lipid carrier composition and preparation method thereof
  • Nano lipid carrier composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Weigh 2.8g palm oil mixture into a 100mL tall beaker, add 1.2g MCT; put the beaker in a water bath at 80℃, melt and mix with 500rpm magnetic stirring; weigh 1.9g Tween 80 dissolved in 74.1g water, and place Stir while heating on the magnetic stirrer. When the mixture is uniform and the temperature reaches 80°C, gradually add the hot surfactant aqueous solution to the mixed oil phase, and magnetically stir at 500 rpm for 10 minutes to form colostrum; place the obtained colostrum in ultrasonic cells Ultrasound on the pulverizer, power 450W, ultrasonic 3s, intermittent 3s, total 15min; quickly transfer the obtained nanoemulsion to an ice water bath at 0°C, and cool to room temperature to prepare a nanolipid carrier suspension.

[0068] Dilute a drop of the suspension into 1 mL of deionized water. The measured particle size is 144.4±1.35nm, and the PDI index is 0.214±0.012. Weigh 4.5 mg of the sample and perform the DSC program. No melting peak or crystallization peak was foun...

Embodiment 2

[0070] Weigh 2.8g hydrogenated sunflower seed oil in a 100mL tall beaker, add 1.2g MCT; put the beaker in a water bath at 80℃, melt and mix with 500rpm magnetic stirring; weigh 1.9g Tween 80 dissolved in 74.1g water, and place Stir while heating on a magnetic stirrer. When the mixture is uniform and the temperature reaches 80°C, gradually add the hot surfactant aqueous solution to the mixed oil phase, and magnetically stir at 500 rpm for 10 minutes to form colostrum; Ultrasound on the cell pulverizer, power 450W, ultrasonic 3s, intermittent 3s, a total of 15min; quickly transfer the obtained nanoemulsion to an ice water bath at 0°C and cool to room temperature to prepare a nanolipid carrier suspension.

[0071] Dilute a drop of the suspension into 1 mL of deionized water, and determine the particle size to be 195.9±1.04nm and the PDI index to be 0.303±0.044. Weigh 5.32 mg of the sample and perform the DSC program. The peak melting point is 61.9°C and the peak recrystallization pe...

Embodiment 3

[0073] Weigh 7.0g hydrogenated sunflower seed oil in a 100mL tall beaker, add 3.0g MCT; put the beaker in a water bath at 80℃, melt and mix with 500rpm magnetic stirring; weigh 0.7g Tween 80 and dissolve it in 69.3g water, and place Stir while heating on a magnetic stirrer. When the mixture is uniform and the temperature reaches 80°C, gradually add the hot surfactant aqueous solution to the mixed oil phase, and magnetically stir at 500 rpm for 10 minutes to form colostrum; Ultrasound on the cell pulverizer, power 450W, ultrasonic 3s, intermittent 3s, a total of 15min; quickly transfer the obtained nanoemulsion to an ice water bath at 0°C and cool to room temperature to prepare a nanolipid carrier suspension.

[0074] Dilute a drop of the suspension into 1 mL of deionized water, and the measured particle size is 398.0±13.30nm, and the PDI index is 0.363±0.155. Weigh 4.72 mg of the sample and perform the DSC program. There are two melting point peaks, the melting point peaks are 62...

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Abstract

The invention relates to a nano-liposome carrier, and specifically relates to a nano-liposome carrier comprising solid liposome and liquid liposome. The invention also relates to the application of the nano-liposome in embedding active substances and in foodstuffs.

Description

Technical field [0001] The present invention relates to nano lipid carriers, in particular to nano lipid carriers containing solid lipids and liquid lipids. The invention also relates to the application of the nano lipid carrier in embedding drugs, embedding food functional factors and embedding nutrients. Background technique [0002] Nanostructured Lipid Carrier (NLC) is a new type of colloidal carrier system developed on the basis of traditional solid lipid nanoparticles (SolidLipid Nanoparticles, SLN). SLN is mainly composed of a mixture of different types of solid lipids. The resulting SLN lipids are likely to form perfect crystals during storage, which may cause the leakage of drugs. However, the difference of NLC is that liquid lipids are added to solid lipids, so that the disorder of the crystals increases, so that the carrier has higher crystal defects and can accommodate more drug molecules. It is precisely because NLC is composed of a mixture of solid lipids and liqu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/00A61K47/44A61K9/14A61K8/92A61K8/02
Inventor 郑妍郑敏英杨天奎徐学兵
Owner WILMAR SHANGHAI BIOTECH RES & DEV CENT
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