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Preparation method of water-soluble nanoparticles

A nanoparticle, water-soluble technology, applied in the field of preparation of nanomaterials, can solve problems such as limiting the application of nanocrystals and hindering contact, and achieves the effects of low cost, good repeatability, and wide application range

Inactive Publication Date: 2015-05-13
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these bulky wrapping molecules form a huge barrier on the surface of the nanocrystal, which hinders the contact of other molecules with the surface of the nanocrystal, which limits the application of nanocrystals in optoelectronics and catalysis.

Method used

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  • Preparation method of water-soluble nanoparticles
  • Preparation method of water-soluble nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] In parts by weight, the formula is as follows:

[0030] IA-dPEG 10 parts

[0031] Oil-soluble nano gold 1000 parts

[0032] Preparation Process:

[0033] a. Synthesis of compound IA-dPEG: In parts by weight, 440 parts of iminodiacetic acid (IA) was suspended in water at 5°C, and then 110 parts of benzyl chloroformate (Cbz) and 10000 parts of benzyl chloroformate (Cbz) and 10000 parts of Parts of NaOH aqueous solution (concentration is 2 M). The above mixture was stirred at room temperature for 1 hour, diethyl ether was added to the reaction liquid to separate layers to remove excess benzyl chloroformate, and the aqueous phase was collected. Use 1M hydrochloric acid to adjust the pH of the aqueous phase to about 2, add ethyl acetate to the extraction reaction solution, separate the ethyl acetate layer, dry over sodium sulfate, filter, and concentrate in vacuo to obtain compound 1 as an oily substance. 200 parts of compound 1, 860 parts of monomethyl ether-capped poly...

Embodiment 2

[0038] In parts by weight, the formula is as follows:

[0039] IA-dPEG 5 parts

[0040] Oil-soluble CdSe / CdS / ZnS quantum dots 400 parts

[0041] Preparation Process:

[0042] a. Prepare IA-dPEG-DTC in the same manner as in Example 1.

[0043] b. Add 5 parts of IA-dPEG-DTC to 400 parts of oil-soluble quantum dot solution, stir for 20 minutes and then add water to obtain an aqueous solution of quantum dots. Acetone is added to the aqueous solution, and after centrifugal purification, the water-soluble quantum dots modified by IA-dPEG-DTC can be obtained.

[0044]After ligand exchange, the obtained quantum dots can be uniformly dispersed in aqueous solution. After the ligand exchange, the UV-visible absorption curve of the quantum dots hardly changes, the shape and size of the quantum dots do not change, and the good monodispersity is maintained.

Embodiment 3

[0045] Embodiment 3: by weight, the formula is as follows:

[0046] IA-dPEG 10 parts

[0047] Oil-soluble nano iron oxide 1500 parts

[0048] Preparation Process:

[0049] a. Prepare IA-dPEG-DTC in the same manner as in Example 1.

[0050] b. Add 5 parts of IA-dPEG-DTC to 1500 parts of oil-soluble quantum dot solution, stir for 20 minutes and then add water to obtain an aqueous solution of nanometer iron oxide. Acetone is added to the aqueous solution, and after centrifugal purification, the water-soluble nano iron oxide modified by IA-dPEG-DTC can be obtained.

[0051] After the ligand exchange, the obtained nano-iron oxide can be uniformly dispersed in the aqueous solution. After ligand exchange, the UV-visible absorption curve of the quantum dots hardly changed, the morphology and size of the nano-iron oxides did not change, and the good monodispersity was maintained.

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Abstract

The invention relates to a preparation method for preparing water-soluble nanoparticles by adopting a ligand exchange method. The method comprises the following specific steps of: introducing two water-soluble polyethylene glycol chains onto iminodiacetic acid; reacting the compound with carbon bisulfide to generate a carbon bisulfide derivative which has a thiocarboxylic acid structure and serves as a ligand; and performing ligand exchange on the obtained ligand and oil-soluble nanoparticles to obtain stable water-soluble nanoparticles. The water-soluble nanoparticles prepared by the method can be suitable for a plurality of fields of biology, photoelectric materials, catalysis and the like.

Description

technical field [0001] The invention relates to a method for preparing nanoparticles, in particular to a method for preparing water-soluble nanoparticles, and belongs to the field of nanomaterial preparation. Background technique [0002] In the past decade, colloidal nanocrystals have been widely used in optoelectronic devices, photovoltaic solar cells, catalysis, and biotechnology, all of which are related to their properties. The properties of nanocrystals are related to their own size and shape, and their properties will also change with the change of size and shape. Their inherent high specific surface area makes the surface of nanocrystals have a large number of unsaturated atoms. In order to stabilize and functionalize nanocrystals, organic surfactants are usually adsorbed on the surface of nanocrystals to passivate their dangling bonds. Organic surfactants play a role in stabilizing the dispersion system of nanocrystals, and at the same time determine some physicoc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/16B22F1/00C09K11/02C09K11/88B82Y30/00B82Y40/00C01B13/14C01B17/20
Inventor 刘璐闫志强何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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