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Anti-anxiety and sleep promoting medicine composition

A technology for promoting sleep and anti-anxiety, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of drug toxicity, side effect, poor effect, rebound effect, etc., to achieve high bioavailability, beneficial to subsequent preparations, effect obvious effect

Inactive Publication Date: 2014-04-16
重庆璧优特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medicine has no ideal treatment method for anxiety disorder and the anxious insomnia caused by it. For a long time, sedative and hypnotic drugs such as diazepam, buspirone, fluoxetine, etc. have been used. There are still problems such as curative effect rebound and drug side effects, and the effect is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, the preparation of the pharmaceutical composition of anti-anxiety and promoting sleep

[0028] The formula is as follows:

[0029] Formula 1: Coptidis 98g, cinnamon 1g, sodium chloride 0.1g.

[0030] Formula 2: Coptidis 40g, cinnamon 50g, sodium chloride 10g.

[0031] Formula 3: Coptidis 40g, cinnamon 30g, sodium chloride 30g.

[0032] Formula 4: Coptidis 90g, cinnamon 9g, sodium chloride 0.2g.

[0033] The preparation method is as follows:

[0034] Preparation method 1: Weigh Coptis chinensis, cinnamon and sodium chloride according to the formula; crush the cinnamon in the formula amount into 10-mesh powder for later use; extract the Coptis chinensis in the formula amount with water at room temperature for 2 times, adding 1 g of Coptis chinensis each time 20ml of water, extract 24 hours each time, combine the two extracts, recover the solvent and concentrate to a density of 1.10 g / mL, add sodium chloride, crystallize for 12 hours, and dry at 100°C t...

Embodiment 2

[0040] Example 2. Validation of the effect of the pharmaceutical composition for anti-anxiety and sleep promotion

[0041] 1) Take the 20 anti-anxiety and sleep-promoting medicinal compositions prepared in Example 1 according to formulas 1-4 and preparation methods 1-5, and add water to make 500 mL of medicinal liquid (each mL contains 0.2 g of crude drug), as Experimental drugs 1~20.

[0042] 2) Prepare the control drugs 1~5 according to the following method:

[0043] Control drug 1: Take 100 g of Coptis rhizome, extract with 600 mL of 70% ethanol aqueous solution under reflux for 3 times, extract for 1 hour each time, recover the solvent, add water to make 500 mL of liquid medicine (each mL contains 0.2 g of crude drug).

[0044] Control drug 2: take 100 g of cinnamon, crush it into 200-mesh powder, add water to make 500 mL of liquid medicine (each mL contains 0.2 g of crude drug).

[0045] Control drug 3: Take 100g of sodium chloride and add water to make a 500mL medici...

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PUM

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Abstract

The invention discloses an anti-anxiety and sleep promoting medicine composition. The anti-anxiety and sleep promoting medicine composition is prepared from the following raw materials in parts by weight: 40-98 parts of rhizoma coptidis, 1-50 parts of cinnamon and 0.1-30 parts of sodium chloride. A prepraiton method of the anti-anxiety and sleep promoting medicine composition comprises the steps of: crushing the cinnamon into powder with 10-5000 meshes for later use; extracting the rhizoma coptidis with water, a methaonl aqueous solution, an alcohol aqueous solution, methyl or alcohol, recovering the solvent from an extracting solution, concnetrating the extracting solution till the density is 1.10-1.40g / mL, adding sodium chloride, crystallizing for 12-72 hours, drying at 60-100 DEG C to obtain rhizoma coptidis extract-sodium chloride complex, and then uniformly mixing the complex and powdered cinnamon to obtain the medicine compistion; the rhizoma coptidis, the cinnamon and the sodium chloride in the medicine compoistion have synergistic effects so that effective consituents are absorbed quickly, and the medicine compoisiton takes effect quickly and has high biological availability and obvious anti-anxiety and sleep promoting effects; in addition, the anti-anxiety and sleep promoting medicine composition is beneficial to preparation, carrying and taking and has good patient compilance due to small size; and the medicine composition is simple and convenient to prepare and low in cost.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a pharmaceutical composition. Background technique [0002] An anxiety disorder is a mood disorder characterized by persistent nervousness, worry, fear, or panic attacks, with autonomic symptoms and behavioral features such as restlessness in movement, including generalized anxiety disorder (chronic anxiety disorder) and panic attacks state (acute anxiety disorder). Anxiety disease belongs to the category of emotional diseases in traditional Chinese medicine, and is considered to be caused by emotional discomfort and stagnation of qi. Thoughtful thinking can easily injure the spleen, which in turn can easily lead to stagnation of blood, phlegm, heat, food, etc. Therefore, anxiety is often accompanied by a variety of physical symptoms. For example, patients with anxiety disorders have sleep disorders of varying degrees, also known as anxiety-induced insomnia, with difficulty falling asleep ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P25/20A61P25/22A61K33/14
Inventor 叶小利李学刚
Owner 重庆璧优特生物科技有限公司