Preparation method for celecoxib

Abstract

The invention relates to a preparation method for celecoxib, and belongs to the field of chemical pharmaceuticals. The method comprises the step of performing cyclization reaction on 4, 4, 4-trifloro-1-(4-tolyl)-1, 3-butanedione and p-sulfamine phenylhydrazine or 4-sulfamine phenylhydrazine hydrochloride in a solvent to obtain a celecoxib coarse product, wherein the solvent for cyclization reaction is a low molecular organic acid or a low molecular organic acid aqueous liquor. According to the method, the product is high in yield, good in purity, easy to purity, good in quality and low in cost; and the method is environment-friendly in condensation process, and is suitable for large-scale industrial production.

Description

technical field

[0001] The invention relates to a preparation method of a non-steroidal anti-inflammatory drug, in particular to a preparation method of celecoxib, which belongs to the field of chemical pharmacy. Background technique

[0002] Traditional non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen, diclofenac sodium, and indomethacin, inhibit cyclooxygenase-II (COX-2) while inhibiting cyclooxygenase-1 (COS-1). There are also undesirable inhibitory effects, resulting in gastrointestinal side effects and even severe digestive tract damage. The COX-2 inhibitors represented by celecoxib are a new generation of non-steroidal anti-inflammatory drugs, which can selectively inhibit COX-2 and have no obvious inhibitory effect on COX-1. It has significant anti-inflammatory, antipyretic and analgesic effects, but does not cause digestive tract damage. It is an excellent anti-inflammatory analgesic drug. It has been reported that celecoxib also has preventive an...

Images