Gynecological antimicrobial gel recipe and preparation method thereof

Abstract

The invention discloses a gynecological antimicrobial gel recipe and a preparation method thereof. A gel takes chitosan-iodine as a main active ingredient and comprises raw materials of chitosan-iodine, glacial acetic acid, polysorbate-20, glycerin, potassium iodate, chitosan, hydroxyethyl cellulose and purified water. The preparation method comprises the following steps of: (1) weighing according to the recipe for standby; (2) adding the glacial acetic acid, the polysorbate-20, the glycerin and part of the purified water into the chitosan-iodine to be fully and uniformly mixed, and completely dissolving for standby; (3) taking a small amount of purified water to dissolve the potassium iodate, adding the dissolved potassium iodate into standby materials to be mixed, and stirring uniformly; (4) adding the chitosan according to the raw material mass ratio, and stirring to dissolve the chitosan; and (5) adding the hydroxyethyl cellulose according to the raw material mass ratio, adding the residual purified water to 100% and slowly stirring to form the gel. The gel has the advantages of good stability, excellent sterilization effect and convenience in use; and the processed gel can be used for treating colpitis mycotica, mixed vaginitis and the like as well as chronic cervicitis.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a chitosan iodine-containing dressing, in particular to a gynecological antibacterial gel. Background technique [0002] Iodine has been used for body disinfection for 150 years, but due to the low solubility of iodine in water, it is only 1.315×10 at 25°C. -3 mol / L, cannot be made into water-based preparations, easy to sublimate at room temperature, unstable in content, and irritating to skin and mucous membranes, etc., which limit its wide application. At present, most of the widely used iodine disinfectants are based on organic polymers or surface active substances, and through the network structure or micelles formed between the carrier molecules, iodine is "bound" in it by the conformational effect of electrons and space. , thereby changing the free state of iodine in general iodine preparations, enhancing its stability and bactericidal effect, and reducing irritation and yellow staini...

AI Technical Summary

Problems solved by technology

[0004] In the Chinese patent database, there are not many patent applications involving the use of chitosan to make gynecological antibacterial gel preparations. No. 201210135254.5 "Chitosan Gyn