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Phloroglucin orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and phloroglucinol, which is applied in pharmaceutical formulations, medical preparations of non-active ingredients, pill delivery, etc., can solve problems such as high equipment cost, complex process of oral freeze-dried tablets, patent infringement, etc.

Active Publication Date: 2013-05-29
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process of oral freeze-dried tablets is complicated, the cost of equipment is high, and problems such as patent infringement are involved

Method used

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  • Phloroglucin orally disintegrating tablet and preparation method thereof
  • Phloroglucin orally disintegrating tablet and preparation method thereof
  • Phloroglucin orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: Preparation of orally disintegrating tablet of the present invention

[0044] 1. Prescription

[0045] Main drug - phloroglucinol, 80 g;

[0046] Bulking agent - mannitol, 30 g;

[0047]Disintegrant - hydroxypropyl cellulose, 40 g;

[0048] Disintegrant - Polysorbate 80, 1 g;

[0049] Adhesive - povidone K30, 5 g;

[0050] Adhesive - starch, 2 g;

[0051] Lubricant - polyethylene glycol 6000, 1.5 g;

[0052] Lubricant - magnesium stearate, appropriate amount;

[0053] Stabilizer - L-malic acid, 0.1 g;

[0054] A total of 1000 tablets were prepared, specification: 80mg (calculated as phloroglucinol dihydrate).

[0055] Second, the method

[0056] 1. Grind the main drug phloroglucinol, pass through a 100-mesh sieve, and set aside;

[0057] 2. Crush the auxiliary materials, pass through a 100-mesh sieve, and set aside;

[0058] 3. Weigh the main drug and auxiliary materials (mannitol, hydroxypropyl cellulose, povidone K30, L-malic acid) according t...

Embodiment 2

[0068] Embodiment 2: Preparation of orally disintegrating tablet of the present invention

[0069] 1. Prescription

[0070] Main drug - phloroglucinol, 80 g;

[0071] Bulking agent - mannitol, 15 g;

[0072] Disintegrant - hydroxypropyl cellulose, 15 g;

[0073] Disintegrant - polysorbate 80, 1 g;

[0074] Adhesive - starch, 2 g;

[0075] Lubricant - polyethylene glycol 6000, 1.5 g;

[0076] Lubricant - magnesium stearate, appropriate amount;

[0077] Stabilizer - L-malic acid, 0.1 g;

[0078] A total of 1000 tablets were prepared, specification: 80mg (calculated as phloroglucinol dihydrate).

[0079] Second, the method

[0080] 1. Grind the main drug phloroglucinol, pass through a 100-mesh sieve, and set aside;

[0081] 2. Crush the auxiliary materials, pass through a 100-mesh sieve, and set aside;

[0082] 3. Weigh the main drug and auxiliary materials (mannitol, hydroxypropyl cellulose, L-malic acid) according to the prescription ratio, and mix them. The addition...

Embodiment 3

[0092] Embodiment 3: Preparation of orally disintegrating tablet of the present invention

[0093] 1. Prescription

[0094] Main drug - phloroglucinol, 80 g;

[0095] Bulking agent - mannitol, 15 g;

[0096] Disintegrant - hydroxypropyl cellulose, 40 g;

[0097] Disintegrant - polysorbate 80, 1 g;

[0098] Adhesive - starch, 2 g;

[0099] Lubricant - polyethylene glycol 6000, 1.5 g;

[0100] Lubricant - magnesium stearate, appropriate amount;

[0101] Stabilizer - L-malic acid, 0.1 g;

[0102] A total of 1000 tablets were prepared, specification: 80mg (calculated as phloroglucinol dihydrate).

[0103] Second, the method

[0104] 1. Grind the main drug phloroglucinol, pass through a 100-mesh sieve, and set aside;

[0105] 2. Crush the auxiliary materials, pass through a 100-mesh sieve, and set aside;

[0106] 3. Weigh the main drug and auxiliary materials (mannitol, hydroxypropyl cellulose, L-malic acid) according to the prescription ratio, and mix them. The addition...

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Abstract

The invention provides a phloroglucin orally disintegrating tablet and a preparation method thereof. The phloroglucin orally disintegrating tablet is prepared by adding a filler, a disintegrant, a binding agent, a lubricant and a stabilizer into phloroglucin used as an active component. The phloroglucin orally disintegrating tablet provided by the invention has the advantages of high disintegration speed, favorable mouthfeel, simple technological conditions and low equipment cost, and is suitable for large-scale production. The phloroglucin orally disintegrating tablet is convenient for special people, such as old people, patients with dysphagia or patients in particular cases, can greatly enhance the compliance of the patients, is beneficial to effective therapy, and can effectively lower the adverse effect caused by first-pass effect. The invention has the characteristics of high safety, controllable quality and the like, is effective, and is convenient to use.

Description

technical field [0001] The invention relates to orally disintegrating tablets of phloroglucinol, which belongs to the field of medicines. Background technique [0002] Phloroglucinol is a new type of myotropic non-atropine non-papaverine pure smooth muscle antispasmodic, which can directly act on the smooth muscles of the gastrointestinal tract and urogenital tract. Compared with other smooth muscle antispasmodics, phloroglucinol does not have anticholinergic effect, and it will not produce a series of anticholinergic side effects while relieving smooth muscle spasm, nor will it cause hypotension, increased heart rate, and arrhythmia and other symptoms have no effect on cardiovascular function. It is mainly used for acute spasm pain caused by digestive system and biliary tract dysfunction, acute spasmodic urethra, bladder, renal colic, kidney stone expulsion, gynecological spasmodic urethra, abdominal pain caused by various diseases, and endoscopic examination. Treatment o...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/05A61K47/38A61K47/34A61P1/06A61P13/06A61P15/06
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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