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Nanoemulsion spray for inflammation reducing and pain easing of wounds and preparation method of nanoemulsion spray

An anti-inflammatory, analgesic, and nanoemulsion technology, applied in the field of medicine, can solve the problems of single drug route, easy oxidative degeneration, and use restrictions, and achieve the effects of no need for dressing changes, less infection, and pain relief

Inactive Publication Date: 2013-05-29
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The active ingredients of the above-mentioned traditional Chinese medicines are all fat-soluble drugs, the route of administration is single, the absorption rate of external application on the skin is low, and they are easy to be oxidized and denatured, which greatly restricts their use.

Method used

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  • Nanoemulsion spray for inflammation reducing and pain easing of wounds and preparation method of nanoemulsion spray
  • Nanoemulsion spray for inflammation reducing and pain easing of wounds and preparation method of nanoemulsion spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Preparation:

[0066] (1) Weigh the surfactant, co-surfactant, medicated oil, paeonol, azone, and deionized water in the proportion of the formula, and set aside;

[0067] (2) Mix the surfactant and the co-surfactant as the surfactant phase, then add the medicated oil and mix well;

[0068] (3) Add paeonol and azone and mix well;

[0069] (4) Slowly add deionized water at room temperature, and stir while adding deionized water, until a clear, transparent, colorless or yellowish liquid with low viscosity and good fluidity is formed.

[0070] The formula is as follows:

[0071] Component Content

[0072] EL-40 25.5g

[0073] RH-40 12g

[0074] Absolute ethanol 1 g

[0075] PEG-600 0.5g

[0076] Frankincense oil 2.5 g

[0077] Myrrh Oil 2.5 g

[0078] Angelica Oil 1.5 g

[0079] Notopterygium oil 1.5 g

[0080] Parsnip oil 1.5 g

[0081] Paeonol 0.5 g

[0082] Azone 1 g

[0083] Deionized water 50 g.

Embodiment 2

[0084] Example 2 The formula is as follows:

[0085] Component Content

[0086] EL-40 40.5g

[0087] Tween-80 4.5 g

[0088] PEG-600 0.5g

[0089] Frankincense oil 5 g

[0090] Myrrh oil 5 g

[0091] Angelica oil 1 g

[0092] Notopterygium oil 1 g

[0093] Parsnip oil 1.9 g

[0094] Paeonol 0.1 g

[0095] Azone 0.5 g

[0096] 40 g of deionized water.

Embodiment 3

[0097] Example 3 The formula is as follows:

[0098] Component Content

[0099] EL-40 25.5 g

[0100] RH-40 4.5g

[0101] Glycerol 1 g

[0102] PEG-600 0.5 g

[0103] Frankincense oil 1 g

[0104] Myrrh oil 1 g

[0105] Angelica oil 1 g

[0106] Notopterygium oil 1 g

[0107] Parsnip oil 1 g

[0108] Paeonol 1 g

[0109] Azone 2.5 g

[0110] 60 g of deionized water.

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Abstract

The invention discloses nanoemulsion spray for inflammation reducing and pain easing of wounds. Nanoemulsion has grain diameter of 1-100nm and is composed of 30-45% of surfactant, 0.5-5% of cosurfactant, 1-5% of olibanum oil, 1-5% of myrrh oil, 1-2% of angelica oil, 1-3% of notopterygium oil, 1-5% of opoponax oil, 0.1-1% of paeonol, 0.5-2.5% of azone and balance deionized water. The nanoemulsion spray is specific drug for external use and has multiple functions of sterilization, inflammation reducing, deflating, pain reliving, putridity eliminating and muscle engendering, wound-healing promoting and the like. Transdermal absorption rate of each active ingredient in a compound is increased, and the nanoemulsion spray can be directly sprayed to wound surfaces, is needless of debridement, free of clothes pollution, good in astringing and muscle-engendering effect and free of scars, and has new efficacies on eliminating, pus drawing and necrotic tissue removing for skin and external diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical preparation with various functions such as sterilization, anti-inflammation, detumescence, pain relief, removal of putrefaction and growth of muscle, and promotion of wound healing, and a preparation method thereof, specifically a transparent and stable compound water Oil-in-type nanoemulsion and preparation method thereof. [0002] Background technique [0003] Frankincense oil contains the main active ingredients of traditional Chinese medicine frankincense. The traditional Chinese medicine frankincense, also known as smoked luxiang, is a gelatinous resin of the olive family plant frankincense tree, which is produced in Somalia and Ethiopia. Sexually pungent, bitter, warm. Go into the heart, liver, spleen channel. The traditional Chinese medicine frankincense can invigorate blood and promote qi, stimulate menstruation and relieve pain, reduce swelling and promote musc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/328A61K9/107A61P17/02A61K31/122
Inventor 欧阳五庆周莹欧阳伸雨
Owner NORTHWEST A & F UNIV