Moxidectin preparation and preparing method thereof
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A technology of moxidectin and preparation, applied in the field of moxidectin preparation and its preparation
Inactive Publication Date: 2013-06-05
JIANGSU LINGYUN PHARMA
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Problems solved by technology
Moxidectin is a new generation of antiparasitic drugs, and there is no domestic company that produces legal veterinary API products
Method used
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Embodiment 1
[0022] A moxidectin preparation, comprising the following raw materials by weight, 100 parts of moxidectin, 1 part of rhodium complex, 1 part of preservative, 500 parts of water, 5 parts of surfactant, 100 parts of methanol, acetic acid 10 parts of ethyl ester.
[0023] Its preparation method comprises the following steps,
[0024] A. The temperature of the fermented liquid is raised to 600C, adding perlite filter aid, plate and frame filter press to collect the filter cake, and the filtrate enters the sewage treatment;
[0025] B, drying the filter cake to obtain dry mycelium;
[0026] C. Extraction: add 5 times methanol to the dry mycelium to dissolve the active ingredients, filter to obtain the extract, and transport the filter cake;
[0027] D. Resin adsorption: the extraction liquid enters the adsorption resin for adsorption, and elutes to obtain the eluent;
[0028] E. Concentrate the eluate until the eluate becomes turbid and the titer reaches above 11000ug / ml, slowl...
Embodiment 2
[0034] A moxidectin preparation, comprising the following raw materials by weight, 300 parts of moxidectin, 5 parts of rhodium complexes, 5 parts of preservatives, 700 parts of water, 10 parts of surfactants, 400 parts of methanol, acetic acid 50 parts of ethyl ester.
[0035] Its effect of moxidectin preparation of the present invention is:
[0036] On the basis of the introduced strains, through mutagenesis screening of the introduced strains, a stable and high-yielding strain of moxidectin was selected. Using the theory of fermentation pathway engineering and regulation mechanism, following the amplification of the oxygen transfer coefficient KLa, the Industrialized moxidectin production technology. Using this technology, the capacity of the moxidectin-producing strain reaches 4000ug / m; the fermentation extraction yield reaches 89.2%, the synthesis yield is 80%, the total yield is 70%, and the product purity is 92%; the produced moxidectin The quality of the finished prod...
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Abstract
The invention relates to a moxidectin preparation and a preparing method of the moxidectin preparation. The moxidectin preparation and the preparing method of the moxidectin preparation are efficient and can be stored for long time. The moxidectin preparation comprises, by weight, 100-300 parts of moxidectin, 1-5 parts of rhodium coordination compounds, 1-5 parts of preservative, 500-700 parts of water, 5-10 parts of surface active agents, 100-400 parts of methanol, and 10-50 parts of ethyl acetate. In the preparing process, the temperature of fermentation liquor rises to 600 DEG C at first, then fermentation liquor filter aid is added, plate-frame pressure filtration is carried out to collect filter cakes, filter liquid is left for sewage treatment, the filter cakes are dried to obtain dry mycelia, stock solution is obtained after procedures of digestion, resin absorption, elution and centrifugation, and the moxidectin preparation is obtained after granulation, drying and packaging.
Description
technical field [0001] The invention relates to the field of agricultural chemicals, in particular to a moxidectin preparation and a preparation method thereof. Background technique [0002] Moxidectin (Moxidectin), also known as moxidectin, moxidectin, mostatin, moxidectin, moxidectin, as a new type of antiparasitic drug, because of its safety, long-term Effectiveness, high efficiency and other characteristics, and far superior to ivermectin, currently in foreign countries, moxidectin replaces ivermectin as a new generation of anthelmintic antibiotic veterinary medicine has become a trend. Moxidectin is produced by a streptomyces ((S.cyanneogrisensnotwyanogenus) is a semi-synthetic macrolide antibiotic produced by fermentation, which is a derivative of Nemadectin. It was discovered in 1967 by Japan Sankyo Company in the fermentation broth of microorganisms, and has been approved by many experts. He and scholars carried out derivative modification and chemical transformatio...
Claims
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Application Information
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