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Moxidectin preparation and preparation method thereof

A moxidectin and preparation technology, applied in the field of moxidectin preparation, can solve the problems of non-volatile preparation, secondary pollution, and low insecticidal rate

Inactive Publication Date: 2016-11-09
WUHU FOMAN BIOPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a moxidectin preparation and its preparation method, which solves the problem that the traditional moxidectin preparation has a low insecticidal rate, and at the same time, the preparation is not easy to volatilize after use, and it is easy to cause secondary pollution.

Method used

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preparation example Construction

[0016] The present invention provides a preparation method of a moxicillin preparation, wherein the preparation method comprises: inoculating a strain of Streptomyces griseus in a medium for culturing to obtain a suspension M; and subjecting the suspension M to Suction filtration to obtain filter cake N; drying the filter cake N to obtain dry mycelium; mixing the dry mycelium with methanol and filtering to obtain an extract; subjecting the extract to a protection reaction , Oxidation reaction and oximation reaction to obtain moximectin; mixing water, the moximectin, methyl propanol, ethyl acetate and surfactant to obtain the moximectin preparation, wherein, relative to 100 Parts by weight of water, the amount of moximectin is 70-90 parts by weight, the amount of methyl propanol is 20-40 parts by weight, and the amount of ethyl acetate is 10-15 parts by weight. The amount of surfactant used is 1-5 parts by weight.

[0017] In a preferred embodiment of the present invention, in or...

Embodiment 1

[0025] Inoculate the strain of Streptomyces griseus in LB medium for culture to obtain suspension M; suction filter the suspension M to obtain filter cake N; dry the filter cake N (drying temperature 55 ℃, time 5min) to obtain dried mycelium; mix the dried mycelium and methanol, and filter to obtain an extract; subject the extract to a protection reaction, an oxidation reaction and an oximation reaction to obtain moximectin ; Mix 100 g of water, 75 g of the moxicillin, 25 g of methyl propanol, 12 g of ethyl acetate and 2 g of sodium dioctyl succinate sulfonate to obtain the moxicin preparation A1.

Embodiment 2

[0027] The strain of Streptomyces glaucus was inoculated in LB medium for culture to obtain suspension M; the suspension M was suction filtered to obtain filter cake N; the filter cake N was dried (drying temperature 60 ℃, time 10min), to obtain dry mycelium; mix the dry mycelium and methanol, filter to obtain an extract; subject the extract to protection, oxidation and oximation to obtain moximectin ; Mix 100 g of water, 85 g of the moxicillin, 35 g of methyl propanol, 14 g of ethyl acetate and 3 g of sodium dodecyl benzene sulfonate to obtain the moxicin preparation A2.

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Abstract

The invention discloses a moxidectin preparation and a preparation method of the moxidectin preparation. The preparation method comprises the following steps: inoculating streptomyces cyaneogriseus sp. noncyanogenus into a culture medium for culturing, thus obtaining a suspension M; carrying out suction filtration on the suspension M to obtain a filter cake N; drying the filter cake N to obtain dry mycelia; mixing the dry mycelia and methanol, and carrying out filtering to obtain leach liquor; carrying out protective reaction, oxidation reaction and oximation reaction on the leach liquor to obtain moxidectin; and mixing water, the moxidectin, methylpropanol, ethyl acetate and a surfactant, thus obtaining the moxidectin preparation. With the adoption of the moxidectin preparation and the preparation method of the moxidectin preparation, the problems that the traditional moxidectin preparation is relatively low in insect killing rate, and has difficulty in volatilizing after use, so that the secondary pollution is easily caused, are solved.

Description

Technical field [0001] The invention relates to the field of preparation of moximectin, in particular to a preparation of moximectin and a preparation method thereof. Background technique [0002] Moxicillin is a new type of antiparasitic drug, a single-component macrolide antibiotic fermented by Streptomyces. This type of antiparasitic drug is widely used in basic agriculture such as animal husbandry and aquaculture. The insecticidal rate of traditional moximectin preparations is low, and the preparations are not easy to volatilize after use, which is easy to cause secondary pollution. [0003] Therefore, it is an urgent problem to be solved by the present invention to provide a moximectin preparation with high insecticidal rate and volatile after use and a preparation method thereof. Summary of the invention [0004] The purpose of the present invention is to provide a moximectin preparation and a preparation method thereof, which solves the problem of low insecticidal rate of th...

Claims

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Application Information

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IPC IPC(8): A61K47/20A61K47/28A61K31/365A61P33/00
CPCA61K47/20A61K31/365A61K47/28
Inventor 苏福男
Owner WUHU FOMAN BIOPHARMA CO LTD
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