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Slow-release gel preparation containing moxidectin for injection and preparation method of preparation

A technology of moxidectin and sustained-release gel is applied in the field of sustained-release gel preparation and preparation for injection containing moxidectin, which can solve problems such as difficulty in preventing and controlling the spread of parasites across regions, and achieve long-term maintenance of drug effect. , The preparation method is simple, and the biocompatibility is good.

Active Publication Date: 2020-06-30
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the cross-regional spread of parasites has also brought great difficulties to the control

Method used

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  • Slow-release gel preparation containing moxidectin for injection and preparation method of preparation
  • Slow-release gel preparation containing moxidectin for injection and preparation method of preparation
  • Slow-release gel preparation containing moxidectin for injection and preparation method of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dissolve 0.2g of butylhydroxyanisole and 0.3g of 2,6-di-tert-butyl-p-cresol into 1mL of ethanol, add an appropriate amount of sterilized pure water, and stir to dissolve. Add 5 g of moisturizing agent sorbitol to the solution, after mixing, add 1 g of slow-release agent sodium alginate at room temperature, and stir to dissolve. Add 0.05 g of benzalkonium bromide preservative to the solution, and stir to dissolve. Add 0.5 g of sterile moxidectin to the solution after filter membrane sterilization, and disperse at a high speed of 20,000 rpm for 10 minutes under a sterile environment. Then, 18% of P407 and 1% of P188 were added after sterilized treatment, and left to swell naturally at 4°C for 48 hours. Finally, sterilized pure water was added to make the volume to 100 mL, and mixed evenly to obtain a 0.5% moxidectin sustained-release gel preparation for injection.

Embodiment 2

[0030]Dissolve 0.5g of 2-tert-butylphenol into 1mL of ethanol, add an appropriate amount of sterilized pure water, and stir to dissolve. Add 10 g of humectant PEG 400 to the solution, and after mixing, add 0.05 g of preservative benzyl alcohol to the solution, and stir to dissolve. After the solution is sterilized by a 0.45 μm filter membrane, the temperature of the solution is raised to 60°C, and 0.1 g of the slow-release agent polyethylene glycol-polylactic acid-polyethylene glycol triblock copolymer is added under sterile conditions, and after stirring and mixing , Add 1 g of sterile moxidectin to the solution, and disperse at a high speed of 20,000 rpm for 10 minutes. Then, return to room temperature, add 18% P407 and 1% P188 after sterilization, and let it swell naturally at 4°C for 48h. Finally, sterilized pure water was added to make the volume to 100 mL, and mixed evenly to obtain a 1% moxidectin sustained-release gel preparation for injection.

Embodiment 3

[0032] Dissolve 0.5g of 2,6-di-tert-butyl-p-cresol into 1mL of ethanol, add an appropriate amount of sterilized pure water, and stir to dissolve. Add 5 g of moisturizing agent sorbitol to the solution, after mixing, add 2 g of slow-release agent methylcellulose at room temperature, and stir to dissolve. Add 0.05 g of benzalkonium bromide preservative to the solution, and stir to dissolve. Add 2 g of sterile moxidectin to the solution after filter membrane sterilization, and disperse at a high speed of 20,000 rpm for 10 minutes under a sterile environment. Then, add 22% P407 and 1% P188 after sterilization, and let it swell naturally at 4°C for 48-72h. Finally, sterilized pure water was added to make the volume to 100 mL, and mixed evenly to obtain a 2% moxidectin sustained-release gel preparation for injection.

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Abstract

The invention discloses a slow-release gel preparation containing moxidectin for injection and a preparation method of the preparation. The slow-release gel preparation containing moxidectin for injection is prepared by using moxidectin, a slow-release agent, a moisturizer, a preservative and a gel substrate according to a certain ratio and the certain method. The preparation has a high-efficiencykilling effect on the digestive tract nematodes and parasites on the body surfaces of pets such as domestic animals, dogs and cats, especially on nematodes resistant to ivermectin in sheep, and can effectively prevent and control parasitic diseases of the domestic animals, the dogs and the cats in vivo and vitro. The gel preparation provided by the invention has the characteristics of the simplepreparation method, good biocompatibility, slow release and high efficiency, and can be used for subcutaneous and intramuscular local injection to prevent and control the parasitic diseases of the pets such as the domestic animals, the dogs and the cats.

Description

technical field [0001] The invention relates to the field of slow-release gel preparations, in particular to a slow-release gel preparation for injection containing moxidectin and a preparation method thereof. Background technique [0002] Parasitic diseases are one of the main diseases threatening the cattle and sheep breeding industry, and the incidence rate accounts for about one-third of the cattle and sheep diseases. Cattle and sheep parasitic diseases directly affect the production performance of sheep, reduce the quality of meat, and reduce economic benefits. Cattle and sheep parasitic diseases are mainly caused by worms, insects, protozoa, etc., and each region has certain distribution characteristics. Insect eggs, larvae and oocysts can all be excreted with the feces of sick cattle and sheep, polluting forage and drinking water, and increasing the risk of parasitic disease transmission. The summer and autumn seasons in pastoral areas are more serious, the activiti...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/365A61K47/36A61K47/34A61K47/38A61K47/10A61K47/26A61P33/10A61P33/14
CPCA61K9/0019A61K9/06A61K31/365A61K47/10A61K47/26A61K47/34A61K47/36A61K47/38A61P33/10A61P33/14
Inventor 阮祥春魏青吴育发汤春莲张莉刘华许世富程帮照
Owner ANHUI AGRICULTURAL UNIVERSITY
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