Qualitative and semi-quantitative analysis method for sample detection by ion mobility spectrometry

A technology of ion mobility spectrometry and quantitative analysis, applied in the field of qualitative and semi-quantitative analysis of samples detected by ion mobility spectrometry, to achieve the effects of easy portability, easy correction, and simple measurement methods

Inactive Publication Date: 2013-06-05
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Application Information

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Problems solved by technology

However, the quantitative analysis of ion mobility spectrometry has not bee

Method used

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  • Qualitative and semi-quantitative analysis method for sample detection by ion mobility spectrometry
  • Qualitative and semi-quantitative analysis method for sample detection by ion mobility spectrometry
  • Qualitative and semi-quantitative analysis method for sample detection by ion mobility spectrometry

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Experimental program
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Effect test

Embodiment 1

[0041] In the present invention, the FK (fentanyl citrate anesthetic) sample is taken as an example to illustrate the qualitative analysis of the ion mobility spectrum and determine the peak time of the sample. according to Figure 1-3 The interface asks for relevant information to be entered.

[0042] During the experiment, the transfer tube temperature was 100°C, the injector temperature was 180°C, and the carrier gas (air) and drift gas (air) flow rates were 400mL / min and 600mL / min, respectively. The sampling piece containing the sample enters the ion mobility spectrometer for analysis after the solvent is evaporated by the heater at 50°C.

Embodiment 2

[0044] Take 1μL of 0.5ppm, 1ppm, and 5ppm respectively with a 1μL microsampler, which is 0.5ng, 1ng, and 5ng; use a 5μL microsampler to take 2μL, 4μL, and 6μL of 10ppm fentanyl citrate anesthetic samples respectively , 8μL, that is, 20ng, 40ng, 60ng, 80ng; the test was first carried out between 0.5-80ng, and finally determined that the semi-quantitative analysis range of FK samples was between 1-60ng. The sampling piece containing the sample enters the ion mobility spectrometer for analysis after the solvent is evaporated by the heater at 50°C. 0.5ng and 80ng are not within the linear range of quantitative analysis.

[0045] The experimental ion mobility spectra of FK samples with different injection amounts (1ng, 5ng, 20ng, 40ng, 60ng) (data are repeated 4 times). Figure 9 Shown is the quantitative relationship curve of the ion mobility spectrometer to the FK sample in the range of 1-60ng. The fitted relational expression is y=1.3451+0.4044x. The quantitative effect of th...

Embodiment 3

[0047] Figure 12 It is the terminal alarm software interface. The alarm indicator light on the left, the red light shows that the sample to be tested is found, and the upper toolbar shows the semi-quantitative analysis value.

[0048] Such as Figure 12 Shown: 50ppm solution, injection volume 1μL (ie 50ng). The software alarm shows 53ng, and the relative deviation of this test is less than 10%.

[0049] Therefore, the quantitative determination of FK samples is feasible under the above conditions. Higher concentration samples can be quantitatively analyzed by diluting between 1-60ng.

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Abstract

The invention discloses a qualitative and semi-quantitative analysis method for sample detection by an ion mobility spectrometry. An ion mobility spectrometry technology is used as the basic detection technology, and the ion mobility spectrometry in a positive ion mold and a negative ion mold is adopted to establish the qualitative and semi-quantitative analysis method to detect different samples. Self-configuration ion mobility spectrometry analysis software can automatically generate a standard curve, automatically input a standard curve equation and automatically alarm to display the quantity of the samples. According to the qualitative and semi-quantitative analysis method for sample detection by the ion mobility spectrometry, a citric acid fentanyl narcotic sample (FK) is used as an example, a standard curve equation y=1.3451+0.4044x is created in the range of 1-60 ng, and a correlation coefficient r is larger than 0.99. The qualitative and semi-quantitative analysis method is simple, quick and efficient and can be widely used in qualitative and semi-quantitative analysis for the sample detection by the ion mobility spectrometry.

Description

technical field [0001] The invention relates to a qualitative and semi-quantitative analysis method for detecting samples by ion mobility spectrometry. Specifically, the ion mobility spectrometry technology is used as the basic detection technology, and the positive and negative ion mode ion mobility spectrometry is used to establish the qualitative and semi-quantitative analysis methods of ion mobility spectrometry to detect different samples. Self-built ion mobility spectrometry analysis software can automatically generate standard curves, automatically import standard curve equations, and automatically alarm to display the number of samples. The method is simple, rapid and efficient, and can be widely used in rapid qualitative and semi-quantitative analysis of ion mobility spectrometry. The method has fast analysis speed, simple test operation, and does not require personnel with special professional background to operate. Background technique [0002] Ion Mobility Spec...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N27/622
Inventor 李海洋王新鞠帮玉李林
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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