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Application of total saponin extract of lobedfruit schizocapsarhizome in treatment of liver cancer and nasopharyngeal carcinoma

A technology of total saponins and cracked potato, which is applied in the fields of medicine and genetic engineering, can solve the problems such as the non-specific anti-tumor effect of the active ingredients of cracked potato, and achieve the effects of large development and utilization value, inhibition of TPK content, and tumor growth inhibition.

Active Publication Date: 2013-06-12
GUANGXI MEDICAL UNIVERSITY
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AI Technical Summary

Problems solved by technology

These studies are still mainly in the preliminary observation of the non-specific anti-tumor effect of the active ingredients of the fruit potato in vitro, and the specific and targeted research on tumor liver cancer and nasopharyngeal carcinoma has not been reported yet.

Method used

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  • Application of total saponin extract of lobedfruit schizocapsarhizome in treatment of liver cancer and nasopharyngeal carcinoma
  • Application of total saponin extract of lobedfruit schizocapsarhizome in treatment of liver cancer and nasopharyngeal carcinoma
  • Application of total saponin extract of lobedfruit schizocapsarhizome in treatment of liver cancer and nasopharyngeal carcinoma

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Embodiment Construction

[0027] Separation of Total Saponins from Cracking Fruit Potatoes

[0028] 1.1 Alcohol extraction

[0029] Crush the medicinal materials and soak them in about 3 times the volume of 75% ethanol solution, and extract them under reflux for 2 hours. Filtrate was obtained by suction filtration. Put the dregs back into the round bottom flask and add the same concentration and volume of ethanol to repeat once. Combine the two medicinal solutions, filter, concentrate to extract, and transfer to a clean bottle for later use. About 10g of extract can be extracted per 100g of dried medicinal materials, and the yield is 10%.

[0030] 1.2 Polar segment extraction

[0031] Mix and grind the extract obtained above with an appropriate amount of silica gel until it becomes a dry powder, place it in a funnel with a sand core, install it on a suction filter bottle, add petroleum ether and suction filter until the extract is colorless, collect the petroleum ether solution obta...

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Abstract

The invention belongs to the field of medicaments and provides an application of natural plant lobedfruit schizocapsarhizome and total saponin extract of the lobedfruit schizocapsarhizome, wherein the natural plant extract is total saponins of the lobedfruit schizocapsarhizome (the Latin name is Schizocapsa plantaginea Hance). The invention provides an extract technology of the total saponin extract of the lobedfruit schizocapsarhizome and the application of the total saponin extract of the lobedfruit schizocapsarhizome in treatment of liver cancer and nasopharyngeal carcinoma. The extract has strong antineoplastic activity and certain targeting property. Serum pharmacology tests prove that the extract still has strong pharmaceutical activity after be absorbed and metabolized, and the saponin extract can inhibit the expression of tumor cells VEGF and CD34 so as to inhibit the growth of capillaries of a tumor tissue and then inhibit the growth of a tumor. A plant source of the extract is a unique plant species, which has great development and utilization value, is planted in a certain scale and is cheap and easily obtained, in Guangxi province. The invention provides an antitumor extract with a wide prospect, so that a novel medicament for treating tumors is provided.

Description

technical field [0001] The invention belongs to the field of medicine and genetic engineering, and relates to the application of cracked potato and its total saponin extract. Background technique [0002] Schizocapsa plantaginea Hance, Latin scientific name: Schizocapsa plantaginea Hance, alias: Qutou chicken, water paparazzi, long beard fruit, winter leaf seven, black winter leaf, Arrowroot Potato, Hakmalian, Hakma Seven, Ma Laotou, Mihewa, Curved Chicken, Water Betel Nut, Water Chicken, Water Radish, Water Sanqi, Shuitianqi, Water Shrimp, Escargot Seven, Soil Fritillaria , soil notoginseng, small field snail seven. It is mostly born on the edge of the ditches and on the meadows of the field ridges. Distributed in Jiangxi, Hunan, Guangdong, Guangxi and Guizhou provinces. The tubers are used as medicine to treat sore throat, acute gastroenteritis, urinary tract infection, toothache, chronic gastritis, gastric and duodenal ulcers, rheumatoid arthritis, irregular menstruati...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P35/00A61P1/16A61P11/02A61P11/04
Inventor 梁钢孙悦文唐安洲
Owner GUANGXI MEDICAL UNIVERSITY
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