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Preparation method of three-dimensional porous membrane with ordered hierarchical nano-structure

A nanostructured, three-dimensional porous technology, applied in the direction of medical preparations of non-active ingredients, fiber treatment, pharmaceutical formulations, etc., can solve the problems of unfavorable cell growth, poor spinnability of spider silk protein, etc., and achieve simple process, easy to master, The effect of easy operation

Inactive Publication Date: 2013-06-12
JIAXING UNIV
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Problems solved by technology

However, the spinnability of spider silk protein is poor, and the diameter of the fibers obtained by electrospinning is often in the micron order, and the formed fiber scaffold is a denser two-dimensional structure, and the size of the gap is smaller than the size of the cells, which is not conducive to the growth of cells

Method used

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  • Preparation method of three-dimensional porous membrane with ordered hierarchical nano-structure
  • Preparation method of three-dimensional porous membrane with ordered hierarchical nano-structure
  • Preparation method of three-dimensional porous membrane with ordered hierarchical nano-structure

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Embodiment 1

[0023] In this embodiment, the preparation of a three-dimensional porous scaffold with spider silk / polylactic acid nanoleaf long on ordered nanofibers with hierarchical nanostructures is achieved through the following steps:

[0024] Step 1: Dissolve the polylactic acid masterbatch in 99v / v% hexafluoroisopropanol, and stir it magnetically for about 5 hours to obtain a solution with a concentration of about 12wt%. Natural spider silk was also dissolved in 99v / v% hexafluoroisopropanol, and filtered through a metal sieve to obtain a solution with a concentration of about 1wt%. Then, after mixing the two, continue stirring for about 5 hours to obtain an electrospinning liquid.

[0025] The weight ratio of spider silk protein and polylactic acid in the spinning solution is 1:1, 2:3 and 1:2 respectively, and the optimal weight ratio of spider silk protein and polylactic acid in the spinning solution is 2:3. excellent.

[0026] Step 2: Pour the obtained electrospinning liquid into ...

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Abstract

The invention provides a preparation method of a three-dimensional porous membrane with an ordered hierarchical nano-structure, relates to two polymer materials, and provides a three-dimensional porous membrane with an ordered hierarchical nano-structure and a preparation method thereof. The three-dimensional porous membrane with the ordered nano-structure has a three-dimensional penetrating porous structure, and has an ordered nano-structure with nano-folium growing on orderly arranged nano-fibers. The shape and size of the hierachical nano-structure can be controlled by changing the original weights of the two polymer materials. The preparation method is simple in process and equipment, stable and reliable, and is convenient to operate; and the prepared three-dimensional porous membrane with the ordered hierarchical nano-structure has potential capacity of serving as bracket materials or drug sustained-release materials in the tissue engineering. The technology is simple and practical, and is wide in application range.

Description

technical field [0001] The invention relates to a preparation technology of a three-dimensional porous membrane with an ordered nanostructure, in particular to a scaffold material or drug slow-release material with potential applications in tissue engineering, with a better microstructure, more The preparation technology of materials suitable for the growth of cells and tissues or materials with controllable slow-release function is a combination of electrospinning technology and organic solvent post-treatment technology. Background technique [0002] Nanomaterials with hierarchical nanostructures, especially those with one-dimensional hierarchical nanostructures, are expected to exhibit some new and important functions. Natural spider silk is an ideal controllable slow-release material and tissue engineering scaffold material because of its flexibility, light weight, very high strength and toughness, and good biocompatibility. [0003] Electrospinning, a simple and effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/56A61L27/50A61K47/30A61K47/42A61K47/34D04H1/4382D04H1/728D06M13/127
Inventor 俞巧珍
Owner JIAXING UNIV
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