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Andrographolide and preparation method thereof

A technology of andrographolide, andrographis paniculata, applied in the field of medicine, can solve the problems of difficult industrialized large-scale production, inadvisability and the like

Active Publication Date: 2013-06-12
成都天台山制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the methods provided by these methods have some positive effects under certain conditions, it is regrettable that these methods are difficult to apply to large-scale industrial production, for example, ultrasonic treatment is not advisable in production

Method used

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  • Andrographolide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Embodiment 1, preparation andrographolide

[0105] 1. Preparation process:

[0106] (1) the Andrographis paniculata medicinal material (being pulverized into coarse powder in advance, each batch of feeding amount 10kg) was extracted for 15 hours with 85% ethanol containing 0.05% (w / v) sodium hydroxide by soaking process, and the extract was filtered (specifically The operation is: put the medicinal materials into the dipping tank, add ethanol until the leaf surface is submerged for about 10-20cm, cover and dip, control the dipping temperature at 25-30°C, and use a motor to pump the liquid from the bottom of the dipping tank to the top of the dipping tank to make the dipping Liquid circulation, keep the concentration of impregnating liquid at each position in the tank consistent);

[0107] (2) in the filtrate that step (1) obtains, add 0.25% acetic acid (be 0.25% (w / v) by adding glacial acetic acid to the acetic acid content in the filtrate, also have similar mode of o...

Embodiment 2

[0118] Embodiment 2, preparation andrographolide

[0119] Carry out with reference to embodiment 1, difference is only to use 80% or 95% ethanol in step (1); Obtain two batches of andrographolide samples.

[0120] Results: The residual percentage is between 14-17%; the chromatographic purity of the decolorized liquid is between 79-83%; the content of andrographolide in the final product is between 98.3-98.8%; the content of dehydroandrographolide in the final product is between 0.81-0.84% ; Andrographolide total yield 79-83%. Show that ethanol concentration is all applicable to the method of the present invention in the scope of 80% to 95%.

Embodiment 3

[0121] Embodiment 3, preparation andrographolide

[0122] Carried out with reference to Example 1, the only difference is that in step (1) the dipping process was extracted for 12 hours or 36 hours to obtain two batches of andrographolide samples. After determination, the residual percentages of andrographolide in the residue of step (1) were 14% and 18%, respectively, showing that the prolongation of time had no effect on promoting the extraction rate.

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Abstract

The invention relates to andrographolide and a preparation method thereof. Specifically, the andrographolide provided by the invention contains lower than 2% of dehydrated andrographolide and higher than 95% of andrographolide. In addition, the method for preparing andrographolide comprises the following steps of: (1) extracting a herba andrographitis medicinal material by ethanol, and filtering to reserve an extracting solution; (2) decoloring the filtrate through active carbon, and filtering; (3) concentrating, cooling the concentrate, discarding supernatant liquid, and collecting educt; (4) washing the educt through ethanol to obtain a crude crystal; (5) dissolving the crude crystal through ethanol, decoloring through active carbon and filtering; and (6) concentrating and recrystallizing filtrate, and drying to obtain a product. The method disclosed by the invention is high in extracting efficiency and low in impurity content, and is specifically applicable to industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a kind of andrographolide and a preparation method of the andrographolide. Background technique [0002] Andrographis paniculata (Andrographis paniculata (Burm.F.) Nees) is the dry aerial part of the Acanthaceae plant. It is harvested when the stems and leaves are luxuriant in early autumn and dried in the sun. Andrographis paniculata, also known as spring lotus and autumn willow, is a joy at first sight, Lamicarpa, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass and so on. It has the effects of clearing away heat and detoxification, reducing inflammation, reducing swelling and relieving pain. It is mainly used to treat bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngitis, pneumonia and influenza, etc. It can be used externally to treat sores, furuncles, swollen toxins, and traumatic infections. Mainly produced in...

Claims

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Application Information

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IPC IPC(8): C07D307/60
Inventor 赵东明方专王敬江威侯建轩董国明
Owner 成都天台山制药股份有限公司
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