Andrographolide and preparation method thereof

A technology of andrographolide, andrographis paniculata, applied in the field of medicine, can solve the problems of difficult industrialized large-scale production, inadvisability and the like

Active Publication Date: 2013-06-12
成都天台山制药股份有限公司
View PDF5 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the methods provided by these methods have some positive effects under certain conditions, it is regrettable that these me

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Andrographolide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Embodiment 1, preparation andrographolide

[0105] 1. Preparation process:

[0106] (1) the Andrographis paniculata medicinal material (being pulverized into coarse powder in advance, each batch of feeding amount 10kg) was extracted for 15 hours with 85% ethanol containing 0.05% (w / v) sodium hydroxide by soaking process, and the extract was filtered (specifically The operation is: put the medicinal materials into the dipping tank, add ethanol until the leaf surface is submerged for about 10-20cm, cover and dip, control the dipping temperature at 25-30°C, and use a motor to pump the liquid from the bottom of the dipping tank to the top of the dipping tank to make the dipping Liquid circulation, keep the concentration of impregnating liquid at each position in the tank consistent);

[0107] (2) in the filtrate that step (1) obtains, add 0.25% acetic acid (be 0.25% (w / v) by adding glacial acetic acid to the acetic acid content in the filtrate, also have similar mode of o...

Embodiment 2

[0118] Embodiment 2, preparation andrographolide

[0119] Carry out with reference to embodiment 1, difference is only to use 80% or 95% ethanol in step (1); Obtain two batches of andrographolide samples.

[0120] Results: The residual percentage is between 14-17%; the chromatographic purity of the decolorized liquid is between 79-83%; the content of andrographolide in the final product is between 98.3-98.8%; the content of dehydroandrographolide in the final product is between 0.81-0.84% ; Andrographolide total yield 79-83%. Show that ethanol concentration is all applicable to the method of the present invention in the scope of 80% to 95%.

Embodiment 3

[0121] Embodiment 3, preparation andrographolide

[0122] Carried out with reference to Example 1, the only difference is that in step (1) the dipping process was extracted for 12 hours or 36 hours to obtain two batches of andrographolide samples. After determination, the residual percentages of andrographolide in the residue of step (1) were 14% and 18%, respectively, showing that the prolongation of time had no effect on promoting the extraction rate.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to andrographolide and a preparation method thereof. Specifically, the andrographolide provided by the invention contains lower than 2% of dehydrated andrographolide and higher than 95% of andrographolide. In addition, the method for preparing andrographolide comprises the following steps of: (1) extracting a herba andrographitis medicinal material by ethanol, and filtering to reserve an extracting solution; (2) decoloring the filtrate through active carbon, and filtering; (3) concentrating, cooling the concentrate, discarding supernatant liquid, and collecting educt; (4) washing the educt through ethanol to obtain a crude crystal; (5) dissolving the crude crystal through ethanol, decoloring through active carbon and filtering; and (6) concentrating and recrystallizing filtrate, and drying to obtain a product. The method disclosed by the invention is high in extracting efficiency and low in impurity content, and is specifically applicable to industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a kind of andrographolide and a preparation method of the andrographolide. Background technique [0002] Andrographis paniculata (Andrographis paniculata (Burm.F.) Nees) is the dry aerial part of the Acanthaceae plant. It is harvested when the stems and leaves are luxuriant in early autumn and dried in the sun. Andrographis paniculata, also known as spring lotus and autumn willow, is a joy at first sight, Lamicarpa, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass and so on. It has the effects of clearing away heat and detoxification, reducing inflammation, reducing swelling and relieving pain. It is mainly used to treat bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngitis, pneumonia and influenza, etc. It can be used externally to treat sores, furuncles, swollen toxins, and traumatic infections. Mainly produced in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D307/60
Inventor 赵东明方专王敬江威侯建轩董国明
Owner 成都天台山制药股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap