Preparation method of POSS (Polyhedral Oligomeric Silsesquioxane) hybrid hydrogel capable of being degraded in acid and responding to temperature

A temperature-responsive, hydrogel technology, applied in the field of preparation of intelligent temperature-sensitive gels

Inactive Publication Date: 2013-06-12
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking advantage of the nanometer properties and molecular structure diversity of POSS, POSS hybrid hydrogels still have a lot of room for development, but overall, there are few related studies, especially those involving POSS hybrid multi-responsive gels. There are few gels, and the development of new POSS hybrid smart gels will have great potential by utilizing the biocompatibility of POSS and its characteristics of improving gel responsiveness.

Method used

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  • Preparation method of POSS (Polyhedral Oligomeric Silsesquioxane) hybrid hydrogel capable of being degraded in acid and responding to temperature
  • Preparation method of POSS (Polyhedral Oligomeric Silsesquioxane) hybrid hydrogel capable of being degraded in acid and responding to temperature
  • Preparation method of POSS (Polyhedral Oligomeric Silsesquioxane) hybrid hydrogel capable of being degraded in acid and responding to temperature

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Experimental program
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Effect test

Embodiment 1

[0033] 4gNIPA, 1gNVP, 0.35gOvPOSS, 0.22g organic co-crosslinking agent DTU, 40mg AIBN were placed in a container, and stirred at room temperature for 60 minutes under nitrogen protection until uniform and transparent. Finally, add the catalyst, stir rapidly for 5 minutes and then seal it evenly. After ultrasonically oscillating the above pre-poly solution for 5 minutes, react at 60°C for 8 hours. Afterwards, take out and soak in deionized water repeatedly to change water to remove unreacted monomer and solvent to obtain the product.

[0034]

Embodiment 2

[0036] Put 4.5g NIPA, 0.9g NVP, 0.65g OvPOSS, 0.28g organic co-crosslinking agent DTU, 35.2mg AIBN in a container, and stir at room temperature for 60 minutes under nitrogen protection until it is uniform and transparent. Finally, add the catalyst, stir rapidly for 5 minutes and then seal it evenly. After ultrasonically oscillating the above pre-poly solution for 5 minutes, react at 60° C. for 12 hours. Afterwards, take out and soak in deionized water repeatedly to change water to remove unreacted monomer and solvent to obtain the product.

[0037]

Embodiment 3

[0039] Put 4.2g NIPA, 0.8gNVP, 0.45gOvPOSS, 0.32g organic co-crosslinking agent DTU, 50mg AIBN in a container, and stir at room temperature for 60 minutes under nitrogen protection until it is uniform and transparent. Finally, add the catalyst, stir rapidly for 5 minutes and then seal it evenly. After ultrasonically oscillating the above pre-poly solution for 5 minutes, react at 60° C. for 12 hours. Afterwards, take out and soak in deionized water repeatedly to change water to remove unreacted monomer and solvent to obtain the product.

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Abstract

The invention relates to a preparation method of a hydrogel capable of rapidly responding to temperature change and being slowly degraded in an acid environment. The hydrogel is obtained through free radical solution polymerization at 60 DEG C under the protection of nitrogen gas by taking N-isopropylacrylamide and vinyl pyrrolidone as comonomers and octa(vinyl) polyhedral oligomeric silsesquioxane and 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]undecane as co-crosslinking agents. The hydrogel is stable in a non-acid environment and has remarkable thermosensitivity, and the LCST (Lower Critical Solution Temperature) of the hydrogel is close to the temperature of a human body. When the hydrogel is in the acid environment, parts of crosslinking bonds in the hydrogel rupture so that the hydrogel is slowly degraded. Meanwhile, the hydrogel is better in pressure resistance and high in responsive swelling and deswelling velocity so as to be potentially applied to the fields of oriented drug sustained release and biological tissue engineering.

Description

[0001] technical field [0002] The invention belongs to a preparation method of an intelligent temperature-sensitive gel, and in particular relates to a preparation method of a hydrogel which can realize rapid response to temperature changes and realize slow degradation in an acid environment. [0003] Background technique [0004] Polymer gel is a system composed of a polymer compound with a three-dimensional network structure and a solvent. The polymers in it are connected by van der Waals force, chemical bond force, physical winding force, hydrogen bond force, etc. The network structure cannot be dissolved by solvents but only swells. Responsive polymer gel is a polymer gel whose structure, physical properties, and chemical properties can change with changes in the external environment. When the gel is stimulated by the environment, its structure and properties (mainly the volume) will respond accordingly, such as when the stimulus signals such as the composition of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F226/10C08F230/08C08F224/00
Inventor 陈一
Owner HUNAN UNIV OF TECH
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