Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of flavonoid in pharmacy

A technology of flavonoids and drugs, applied in the application field of subsidence, can solve the problem of not using daily life and so on

Active Publication Date: 2013-06-19
许翔 +1
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Substances such as ionophores are only used in laboratory research to activate some cells, and are not used in people's daily life.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of flavonoid in pharmacy
  • Application of flavonoid in pharmacy
  • Application of flavonoid in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0113] Experimental Example 1: Control Experiment of Staphylococcus aureus Stimulating Human Neutrophils to Synthesize and Release Histamine

[0114] see figure 1 , Staphylococcus aureus stimulates human neutrophils to synthesize and release histamine. different concentrations of live ( figure 1 A) or heat-killed ( figure 1 B) Staphylococcus aureus can stimulate human neutrophils (referred to as "HPMN", the same below) to release histamine (the concentration refers to the ratio of the number of cells to the number of bacteria, abbreviated as "cell: bacteria"; the control group refers to is the neutrophil group without bacteria, the same as the other legends below). This experiment was improved by the method reported previously (Xu Xiang et al., Journal of Leukocyte Biology 2012; 91:275-284), the same below. The control cells themselves produced and released a small amount of histamine. Some cells in the human body can release a small amount of histamine under normal phy...

experiment example 2

[0115] Experimental Example 2: Control Experiment of Staphylococcus aureus Stimulating Human Neutrophils to Synthesize and Release Leukotriene B4

[0116] see figure 2 , the 8325 strain was used in this experiment. Different concentrations of live or heat-killed S. aureus can stimulate the production and release of leukotriene B4 from human neutrophils. The control cells themselves also produced and released very small amounts of leukotriene B4. And dead Staphylococcus aureus can stimulate human neutrophils to synthesize and release more leukotriene B4. Compared with the control group, a high concentration (cell:bacteria=1:100) of dead S. aureus can stimulate cells to newly synthesize more than 63 times of leukotriene B4 and release more than 84 times of leukotriene B4. (**p<0.01, ****p<0.0001, compared to the control group).

experiment example 3

[0117] Experimental example 3 : Control experiments of flavonoids inhibiting the synthesis and release of histamine in human neutrophils stimulated by live or dead Staphylococcus aureus

[0118] see image 3 , The 8325 strain was used in this experiment, and the ratio of cells to Staphylococcus aureus was 1:100. image 3 A, shows that the S. aureus group without flavonoids can significantly stimulate the production and release of histamine from human neutrophils compared with the control group (the newly synthesized histamine increased by 1.5 times compared with the control group and released 65.6-fold increase in histamine). Seven flavonoids at different concentrations can inhibit the production and release of histamine by human neutrophils stimulated by Staphylococcus aureus. % (25mM naringenin group) to more than 75% (50mM genistein group), while the inhibition rate of newly synthesized histamine by S. aureus stimulated cells ranged from 24.3% (10mM naringenin group) ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of flavonoid in preparation of medicines for inhibiting synthesis and release of inflammatory mediators of white blood cells. Generation and release of pro-inflammatory cytokine caused by microorganisms or chemical irritants is inhibited from source, and white blood cells are promoted to generate and release anti-inflammatory factors to facilitate degradation of inflammation.

Description

technical field [0001] The present invention relates to the use of flavonoids, in particular to the use in the field of pharmacy, specifically to the application of flavonoids in inhibiting the synthesis and release of leukocyte inflammatory mediators caused by microorganisms or chemical stimuli, and promoting the production and release of anti-inflammatory factors by leukocytes to promote Application for the resolution of inflammation. Background technique [0002] After several years of long-term research, the inventor found that mycoplasma infection can stimulate neutrophils to synthesize and release a large amount of histamine for the first time in the world, and these histamines play an important role in the lung infection and inflammatory response caused by mycoplasma (Xu Xiang et al. , Journal of Experimental Medicine 2006; 203:2907-2917). In subsequent studies, it was found that many microbial infections including Pseudomonas aeruginosa can also stimulate neutrophil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/352A61K31/353A61K31/12A61P29/00
CPCA61K31/12A61K31/352A61K31/353A61P29/00Y02A50/30
Inventor 许翔王燕
Owner 许翔
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com