37 results about "Chemical irritants" patented technology

Apparatuses and methods to inject chemical stimulants (284) to a production zone (102, 202) through a string of production tubing (110, 210) around a downhole obstruction are disclosed. The apparatuses and methods include deploying an anchor seal assembly (200) to a landing profile (120, 220) located within a string of production tubing (110, 210). The anchor seal assembly (200) is in communication with a surface station through an injection conduit (260, 264) and includes a bypass pathway (262) to inject various fluids to a zone below.

The present invention is concerned with novel compositions containing fresh or virgin beeswaxes and oil, with and without water, and the utilization of such compositions for the treatment of skin in animals including man, for treatment for first, second, and third degree (partial and full thickness) burns due to sunburn, windburn, scalds, flash flame, electrical contact, chemical contact, cold, and the like, for use as a preventive aid for sunburn, windburns, skin chapping, chafing and the like, for promoting and accelerating the healing of burns, abrasions, lacerations, cuts, scratches, dry skin, chapped skin, wind burned skin, friction-type burns, chafing and the like, for use as a softening and moisturizing agent, for use in the reduction of wrinkles, for use as a topical application to irritations of the skin, including dry lips, chapped skin, abrasions, and the like, for use as an analgesic to be applied topically for the treatment and alleviation of pain in the skin and underlying tissues, for use as a protective barrier between the skin and other irritants, eg, saliva, urine, fecal material, various chemical irritants and the like, and for use as a base to which may be added other agents also promoting treatment, moisturization, protective or preventive measures for the skin.

Methods and compositions for the reliable detection of chemical stimuli using a “nose-on-a-chip” are presented. The invention uses cells sensitive to chemical stimuli and detects and processes the signals given by the cells upon contact with chemical stimuli.

Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro in a biodegradable amorphous carrier within the confines of a space bounded by a semi-permeable membrane with a molecular weight cut-off of greater than 100 kDa. The culture can be subjected to physical/physicochemical conditions that mimic in vivo conditions of the tissue in need of repair or replacement. In one embodiment the invention provides an amorphous preparation of chondrocytes and their extracellular products, suitable for injection.

A dormant pressurized or non-pressurized pouch, canister or bag containing a debilitating substance, such as a pepper mace, that deploys when bitten, clawed or otherwise punctured or squeezed. Attached or imbedded on a pet's collar, on a hiker's clothing or on a rancher's animal, the victim does not need to activate any defensive measure when attacked; the attack itself releases the chemicals. The chemical defense system not only curtails any immediate attack due to instant disbursement of debilitating chemical agents, but also allows some protection over time as the victim is temporarily coated with noxious chemicals, and able to escape the attack.

The present invention provides a method of using agents which can modulate TRPA1 function as counteragents to inhibit the physical effects of chemical irritants/toxicants when given prior to exposure or to lessen the physical effects when administered post exposure, and more specifically, to a method for counteracting the acute physical noxious effects of toxicants, including but not limited to, tear gases, chlorine, hydrogen peroxide, ammonia, phosgene, chloropicrin, isocyanates and mustard gas. Administering the counteragents counteracts pain, inflammation, lachrymation, blepharospasm, respiratory irritation and depression, airway mucus secretion, airway obstruction and injury, cough and incapacitation and cutaneous chemical injuries. Another embodiment provides a method of preventing or treating a disease or condition in a mammal, which disease or condition includes hypersensitivity to chemical stimuli, particularly in regards to inflammatory airway conditions, such as asthma, rhinitis, etc., by administering to the mammal a therapeutically effective amount of a compound that inhibits TRPA1 function, wherein the compound reduces the hypersensitivity and mediates the response to such chemical stimuli in the mammal. The invention also includes a kit containing the compound that inhibits the TRPA1 function as a counteracting agent for administration prior to or post exposure to prevent or limit the effects of the exposure.

A formula, a system and a method is provided for treating urushiol induced contact dermatitis, chemical irritants and/or microbiological irritants on an affected area of skin of a user. The formula and/or the system is applied to an area of the skin of the user affected with urushiol, the chemical irritants and/or the microbiological irritants. The formula and/or the system have a cleansing agent, one or more surfactants and/or one or more abrasive agents for treating the urushiol induced contact dermatitis, the chemical irritants and/or the microbiological irritants. One or more abrasive agents separates the urushiol, the chemical irritants and/or the microbiological irritants from the skin of the user at the affected area. The cleansing agent bonds to the urushiol, the chemical irritants and/or the microbiological irritants at the affected area and withdraws the urushiol, the chemical irritants and/or the microbiological irritants from the tissue under the affected area of the skin of the user. The formula, the system, the urushiol, the chemical irritants and/or the microbiological irritants may be rinsed away from and/or may be removed from the affected area of the skin of the user. As a result, the urushiol induced contact dermatitis, the chemical irritants and/or the microbiological irritants is treated and/or is terminated by the formula, the system, the cleansing agent and/or one or more surfactants.

Ecto-NTPDase function on Langerhans cells is demonstrated to counteract the nucleotide inflammatory response caused by certain types of chemical irritants. The present invention takes advantage of this observation by, first, providing methods for screening of chemicals for irritant potential based on their ability to induce nucleotide release from keratinocytes. Second, methods are provided for the prevention and treatment of inflammation using NTPDase protein or gene therapy. And third, there also are provided methods for screening candidate compounds for NTPDase modulatory activity, thereby identifying possible pro- and anti-inflammatory agents. Additionally, the role of NTPDases and P2 receptors in hyperactive immune conditions such as autoimmune diseases and allergic reactions such as allergic contact dermatitis has been demonstrated. Therefore, the invention also provides methods for the prevention and treatment of hyperactive immune conditions by using NTPDase inhibitors and/or P2 receptor inhibitors. Further provided are methods for screening candidate compounds for modulatory activity of NTPDase-mediated immune conditions, thereby identifying other possible immunotherapeutic agents.

The invention discloses application of flavonoid in preparation of medicines for inhibiting synthesis and release of inflammatory mediators of white blood cells. Generation and release of pro-inflammatory cytokine caused by microorganisms or chemical irritants is inhibited from source, and white blood cells are promoted to generate and release anti-inflammatory factors to facilitate degradation of inflammation.

A multifunctional personal safety device includes a main body having an ergonomic gripping surface, and a finger trigger for selectively activating a non-contact deterrent unit and an active deterrent unit. The non-contact deterrent unit including a controller, memory, wireless communication unit, a siren, a light, a laser, and a camera. The information captured by the camera is stored in one or both of a removable media card and the onboard memory. The active deterrent unit includes an aerosol canister containing one or both of a chemical irritant or an inflammatory agent. A safety switch transitions between a locked and unlocked position wherein the finger trigger is selectively blocked and allowed to engage the aerosol canister, respectively.

A personal protection system has a shaft that can be secured into a pair of end bases that mount to a surface of the surroundings of the user. The shaft and bases are configured to appear as a natural part of the surroundings, such as a support bar or rail, when the shaft is stored. The shaft can be removed, and has an end portion adapted to provide a weapon for self defense. For example, the end portion can employ a piercing point, a syringe and needle for injecting a bio-toxin, a canister for spraying a chemical irritant, an appliance for generating an electrical shock, or combinations of these elements. Preferably, the shaft is secured into the bases so as to be usable for support. It is further preferred for the bases to be configured to disguise the fact that the shaft can be removed.

A housing can be mounted to a pistol or other weapon and conveniently fired therefrom and can be used as a discrete weapon itself. A cap has a central aperture which secures the nozzle and/or valve stem of a canister of chemical irritant from movement and is secured to the proximal end of a hollow tube. A feature of the new invention is a slot access running along the length of the tube for some distance from its distal end. The tube may be either open or closed at its distal end. Toward the distal end of the tube, an interior ridge or stop cooperates with the cap aperture to secure the canister of irritant. When a canister is installed in the housing, the operator can release an irritant spray axially from the canister by pressing a digit against the side of the canister's storage cylinder and, thereby, displace its longitudinal axis along an arc. The housing need have no other mechanisms, except the housing and canister. This method also allows for convenient triggering of a spray from a canister within the housing when the housing is secured under or adjacent to the barrel of a handgun. In some embodiments an actuator compresses against a spring-loaded pusher to contact the side of the storage cylinder and move the longitudinal axis of the storage cylinder to release a spray.

I disclose an apparatus for incapacitating an active shooter. The apparatus is easy enough for an untrained person to disable, but not kill, an armed assailant. Lifting the main unit out of a discreet docking station unfurls spring-loaded bullet-resistant shields and a bullet-resistant apron. This motion also releases an alarm button which automatically calls local law enforcement. Simple thumb-operated triggers unleash blinding light, deafening sound waves and a potent chemical irritant toward an attacker up to 30 yards away.

A multifunctional personal safety device includes a main body having an ergonomic gripping surface, and a finger trigger for selectively activating a non-contact deterrent unit and an active deterrent unit. The non-contact deterrent unit including a controller, memory, wireless communication unit, a siren, a light, a laser, and a camera. The information captured by the camera is stored in one or both of a removable media card and the onboard memory. The active deterrent unit includes an aerosol canister containing one or both of a chemical irritant or an inflammatory agent. A safety switch transitions between a locked and unlocked position wherein the finger trigger is selectively blocked and allowed to engage the aerosol canister, respectively.

The present invention relates to a sensor device for detecting the amount of or changes in chemical stimuli in a gaseous or liquid phase analyte (e.g. a microanalyte) having means for intimately exposing at least a part of the (or each) sensing element to the localised environment containing the chemical stimuli.

Disclosed is a pepper spray composition comprising: (a) a chemical irritant; (b) a propellant, wherein the propellant comprises transHFO-1234ze; (c) a solvent, wherein said solvent comprises transHFO-1233zd; and (d) a non-ionic surfactant and/or an ionic surfactant.

The invention discloses a bromhidrosis eliminating body deodorant. The bromhidrosis eliminating body deodorant is prepared from, by weight, 6-8 parts of Flos Nelumbinis, 4-7 parts of Radix Astragali, 8-10 parts of Radix Paeoniae Alba, 6-11 parts of musk, 11-15 parts of Flos Chrysanthemi Indici, 8-12 parts of Herba Menthae, 7-11 parts of rose extract, 8-10 parts of lily extract, 4-9 parts of gaultheria extract, 5-8 parts of Ledum Groenlandicum essential oil, 8-10 parts of olive oil, 6-10 parts of Radix Aristolochiae and 6-11 parts of ethyl alcohol. The bromhidrosis eliminating body deodorant is effective in bromhidrosis elimination, sweating arresting and deodorization, free of chemical irritant components, fragrant and low in cost.