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Production method for chemicals by continuous fermentation

A technology for chemicals and fermentation raw materials, applied in biochemical equipment and methods, chemical instruments and methods, and methods for sampling biological materials, etc., can solve problems such as complex cleaning steps, reduce costs, reduce processing costs, and improve fermentation production. The effect of efficiency

Inactive Publication Date: 2013-06-19
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] As described above, conventional techniques have not solved the problems of complicated cleaning steps, treatment of waste liquid generated through cleaning, maintenance of filtration performance, and control of excessive microbial concentration for high-concentration cultured microorganisms

Method used

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  • Production method for chemicals by continuous fermentation
  • Production method for chemicals by continuous fermentation
  • Production method for chemicals by continuous fermentation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] First prepare the membrane module. The hollow fiber membranes used to prepare the membrane module were prepared by disassembling the Toray pressure polyvinylidene fluoride hollow fiber membrane module HFS1020 and cutting off only the part of the polyvinylidene fluoride hollow fiber membrane that was not attached and fixed to the module. A molded product of polycarbonate resin was used as the separation membrane module unit. The membrane module has a volume of 0.06L and 200cm 2 effective filter area. The porous hollow fiber membranes and membrane modules thus prepared are used for continuous fermentation. Unless otherwise stated, the operating conditions used in Example 1 are as follows.

[0083] Operating conditions:

[0084] -Volume of fermenter: 2.0L

[0085] - Effective volume of fermenter: 1.5L

[0086] - Separation membrane used: polyvinylidene fluoride hollow fiber membrane (60 fibers)

[0087] - Adjustment temperature: 37°C

[0088] - Aeration volume afte...

Embodiment 2

[0119] The continuous fermentation test for D-lactic acid was carried out in the same manner as in Example 1, except that after maintaining the temperature at 60° C. according to the temperature adjustment of the constant temperature unit, the high-temperature water used for backwashing was used from the first 200 hours of continuous fermentation to the 250th hour. The results are shown in image 3 and 4 middle. Therefore, the concentration of microorganisms can be reduced to an OD600 of about 30 and the permeable membrane pressure can be stably maintained. In other words, effective membrane cleaning is possible at controlled microbial concentrations.

Embodiment 3

[0121]The continuous fermentation test for D-lactic acid was carried out in the same manner as in Example 1, except that after maintaining the temperature at 45° C. according to the temperature adjustment of the constant temperature unit, the high-temperature water used for backwashing was used from the first 200 hours of continuous fermentation to the 250th hour. The results are shown in image 3 and 4 middle. Therefore, the concentration of microorganisms can be reduced to an OD600 of about 40 and the permeable membrane pressure can be stably maintained. In other words, effective membrane cleaning is possible at controlled microbial concentrations.

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Abstract

A production method for chemicals by continuous fermentation, comprising: filtering a culture medium containing a fermentation feedstock, chemicals, microbes, or cultured cells by a separation membrane; collecting the chemicals from the filtrate; retaining or refluxing the unfiltered remains in the culture medium; and supplying washing liquid from the permeate side of a membrane unit to wash the membrane in a continuous fermentation in which the fermentation feedstock is added to the culture medium, characterized in that the washing liquid has a higher temperature than the culture medium, and is high-temperature water of 150 DEG C or lower, and a microbial concentration in a fermenter is controlled by supplying the washing liquid. By using the production method, the retention of the filtration property for high cell-density cultivation of microbial mixture and the control of the microbial concentration can be simultaneously performed, in the collection of products by the fermentation using the separation membrane.

Description

technical field [0001] The present invention relates to a method for producing chemicals by continuous fermentation using a separation membrane. Background technique [0002] Separation membranes have been used in various fields including water treatment such as drinking water production, water purification and waste water treatment fields, pharmaceutical production and food industry fields, and have also been applied to the fermentation field. In the field of water treatment such as drinking water production, water purification and wastewater treatment, separation membranes are used to remove water impurities as an alternative to conventional sand filtration and coagulation sedimentation. Separation membrane technology is widely used in wastewater treatment and food industry, where large volumes of high-concentration wastewater or raw materials are loaded into processing vessels and processed while maintaining a high concentration of microorganisms, because this technology ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P1/00B01D65/02B01D65/06C12P7/40C12P7/56
CPCB01D61/18B01D65/02B01D71/34B01D2311/10B01D2321/04B01D2321/08B01D2321/168C12M33/14C12P1/00C12P7/40C12M39/00C12P7/56B01D63/031
Inventor 小林敦千智勋武内纪浩西田诚田中祐之峰岸进一
Owner TORAY IND INC
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