Preparation method of theophylline molecular surface printing material

A technology of surface imprinting and theophylline, which is applied in the field of molecularly imprinted polymers, can solve the problems of low binding performance of template molecules, complicated process, and limited number of imprinted holes.

Inactive Publication Date: 2013-06-26
ZHONGBEI UNIV +1
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] The traditional method of preparing molecularly imprinted polymers is the embedding method, which has the following disadvantages: the obtained imprinted polymers are blocky, and the imprinting efficiency is not high; the process of crushing, grinding and sieving to obtain imprinted polymer particles, the flow complex; and many imprint

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  • Preparation method of theophylline molecular surface printing material
  • Preparation method of theophylline molecular surface printing material
  • Preparation method of theophylline molecular surface printing material

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Embodiment 1

[0036] A preparation method for theophylline molecular surface imprinted material, comprising the following steps:

[0037] 1. Chemical surface modification of silica gel: add 2.5g of activated silica gel and 2.5mL of silane coupling agent KH-590 into 125mL of toluene, react at 110°C for 12h, introduce mercapto groups into the surface of silica gel particles, and obtain surface-modified Silica gel particles MPMS-SiO 2 .

[0038] 2. Chemical grafting of polyglycidyl methacrylate PGMA on the surface of silica gel: 1.2g MPMS-SiO 2 Add 7.8mL monomer GMA to 70mL DMF, nitrogen protection, add 0.0812g BPO, use MPMS-SiO 2 The mercapto groups on the surface and the BPO in the solution constitute a redox initiation system, and react at 55°C for 12 hours to cause surface-initiated graft polymerization of the monomers to prepare grafted particles of PGMA / SiO 2 .

[0039] 3. Salicylic acid functionalization of grafted particles: Add 1.5g of grafted particles PGMA / SiO 2 , then add 30mL...

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Abstract

The invention discloses a preparation method of a theophylline molecular surface printing material, and relates to a molecular printing polymer. The preparation method comprises the following steps of: activating silica gel microparticles; connecting surface chemical bonds of silica gel microparticles with sulfydryl containing silane coupling agents; chemically grafting polyglycidyl methacrylate on surfaces of silica gel microparticles; modifying by 5-aminosalicylic acid; and preparing the surface molecular printing polymer of silica gel microparticles. According to the invention, high performance molecular printing polymer is prepared through a method of graft polymerization and crosslinking printing sequentially. The molecular surface printing material has special identifying selection and excellent combining affinity to theophylline.

Description

technical field [0001] The invention relates to molecularly imprinted polymers, in particular to a method for preparing theophylline molecular surface imprinted materials. Background technique [0002] Alkaloids are a large class of nitrogen-containing natural organic compounds, which are widely found in many kinds of plant tissues, most of which have complex nitrogen heterocyclic structures, and have significant physiological and pharmacological activities, such as anti-tumor, anti-inflammatory, anti-viral and other pharmaceutical functions. Alkaloids have very important application value and huge application potential in the field of medicine. With the rapid increase in the market demand for various alkaloids, scientifically and efficiently extracting, separating and purifying alkaloids from plants has become a concern. science and technology. [0003] At present, solvent extraction methods are generally used to extract alkaloids from plant tissues, such as ultrasonic-a...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F220/32C08F8/32C08J9/26B01J20/26
Inventor 安富强杜瑞奎高保娇李延斌
Owner ZHONGBEI UNIV
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