External preparation of traditional Chinese medicine composition with immune function for treating cow mastitis

An immune function and composition technology, which is applied in the field of external preparations of traditional Chinese medicine compositions for treating dairy cow mastitis, can solve the problems of reducing the use effect of drugs, hindering drugs from entering the inflamed area, etc. effects of stress

Active Publication Date: 2014-10-22
SHANDONG NEW HOPE LIUHE GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, tissue edema also hinders the entry of drugs into the inflammatory area, reducing the effect of various drugs

Method used

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  • External preparation of traditional Chinese medicine composition with immune function for treating cow mastitis
  • External preparation of traditional Chinese medicine composition with immune function for treating cow mastitis

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preparation example Construction

[0065] The present invention also provides a preparation method of the above-mentioned Chinese medicine composition, when the dosage form of the Chinese medicine composition is a coating agent, specifically:

[0066] In the first step, the components are mixed in proportion, stirred evenly to obtain a mixture, and ethanol with an alcohol concentration of 5 to 8 times its mass is added to 60% to 80% ethanol, heated and refluxed for 2 to 4 hours, filtered, and the filter residue is Add ethanol with an alcohol concentration of 60% to 80% that is 2 to 4 times the mass of the mixture again, heat to reflux for 2 to 4 hours, filter, combine the filtrates, heat and concentrate until there is no ethanol smell, add water until the crude drug concentration is 1g / ml~2g / ml to obtain liquid medicine;

[0067] The second step is to take 10g of polyvinyl alcohol and soak it in 80ml of distilled water for 24 hours to make it fully swell, then heat it in a sealed water bath at 90°C to dissolve...

Embodiment 1

[0073] Embodiment 1 Chinese medicine coating agent 1

[0074] Passepartout 25g, Polygonatum 40g, Coptidis 65g, Shouwuteng 35g, Baishao 35g, Astragalus 80g, Chinese yam 45g, Angelica 30g, Solidago 35g, ginseng leaves 55g, catechu 30g, Sanbaicao 25g, Daxueteng Mix 35g, 45g of jujube, 40g of dogwood, 25g of Chuanketong, 55g of Eucommia, 30g of walnut kernel, 45g of Wujiapi and 35g of Rehmannia glutinosa, stir well to obtain a mixture, add 5kg of ethanol with an alcohol concentration of 70%, and heat to reflux After 4 hours, filter, add 2.5kg of ethanol with an alcohol concentration of 70% to the filter residue again, heat and reflux for 4 hours, filter, combine the filtrates, heat and concentrate until there is no ethanol smell, add water until the crude drug concentration is 1g / ml, and obtain a medicinal solution , Take 10g of polyvinyl alcohol and soak it in 80ml of distilled water for 24 hours to make it fully swell, then heat it in a sealed water bath at 90°C to make it disso...

Embodiment 2

[0075] Embodiment 2 Irritation test of Chinese medicine coating agent 1

[0076] Take 5 male and female rabbits (common grade) each, weighing (1.50±0.35) kg, cut short the hair on both sides of the back of the rabbit, and use 10% sodium sulfide to depilate about 4cm×5cm. After 24 hours of depilation, select no damage Skin rabbits are used for spare. They were divided into intact skin group (I) and damaged skin group (II), with 5 rats in each group. After disinfecting the skin of the rabbits in the two groups, cut the skin on the right side with a sterilized No. 6 needle in the shape of "#" to stab the epidermis without injuring the dermis, so that the skin oozes blood. The area of ​​the damaged area is 3cm×3cm. The distance between scratches is 0.5cm, which is used as the test area of ​​damaged skin. The other side was used as a control.

[0077] The right depilatory area of ​​the rabbits in groups I and II was coated with the traditional Chinese medicine coating agent prep...

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Abstract

The invention provides an external preparation of a traditional Chinese medicine composition with an immune function for treating dairy cow mastitis. The crude medicines of the external preparation include fructus liquidambaris, rhizoma polygonati, goldthread, vine of multiflower knotweed, white paeony root, astragalus mongholicus, Chinese yam, angelica sinensis, solidago virgaurea, ginseng leaf, wadalee-gum-tree, saururus chinensis, sargentgloryvine stem, Chinese-date, dogwood, caulis clematidis armandii, eucommia ulmoides, semen juglandis, cortex acanthopanacis and prepared rehmannia root. The traditional Chinese medicine composition can improve the immune ability of the dairy cow when clearing away heat and toxic materials, resisting bacterium and eliminating inflammation, so as to improve the anti-stress ability and the anti-disease ability of the dairy cow, and has the advantages that the external preparation is good in treatment effect, reappearance-resistant, free of medicine resistance, free of residue and free of toxic and side effects in the aspect of treatment of the dairy cow mastitis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine immunization, in particular to an external preparation of a traditional Chinese medicine composition with immune function for treating cow mastitis. Background technique [0002] The mammary gland of a dairy cow is a complex bioreactor in the body. Inside the mammary gland, many protective factors, including cytokines, antibodies, hormones, enzymes and neurotransmitters, etc., together build multiple intricate signaling pathways. The dynamics between these factors Balance is fundamental to maintaining breast health. When inflammation occurs in the mammary glands of dairy cows, the body's resistance decreases, and the expression of cytokines and their receptors in the body will be abnormal. [0003] Cow mastitis (mastitis) refers to a certain type of inflammation in the mammary gland tissue of cows, accompanied by physical, chemical and microbiological changes in milk in diffe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K9/70A61K9/00A61P37/04A61P15/14
Inventor 吕明斌燕磊唐婷婷
Owner SHANDONG NEW HOPE LIUHE GROUP
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