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Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof

A technology of Helicobacter pylori and extract, applied in the field of biopharmaceuticals

Active Publication Date: 2013-08-07
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, screening and discovering active ingredients from higher fungi and their cultures, and applying them to anti-tumor, anti-virus, diabetes, etc., has not only become the development direction of national key research new drugs, but also a hot spot in the development of biomedicine in various countries in the world today. There is no report that screens and discovers active ingredients from medicinal fungi and applies them to anti-Helicobacter pylori

Method used

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  • Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof
  • Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof
  • Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof

Examples

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Effect test

Embodiment 1

[0046] An anti-helicobacter pylori biomedical mycelium extract, the extract is prepared according to the following steps:

[0047](1) Take Hericium erinaceus culture, reflux extraction with ethanol with volume percentage concentration of 50% for 1h, then centrifuge at 4000r / min for 8min, remove the medicinal residues, and obtain the extract; wherein, during reflux extraction, Hericium erinaceus The weight ratio of culture to ethanol is 1:3;

[0048] (2) Rotary steam the extract at 50°C until there is no alcohol smell, add water to precipitate the precipitate, then centrifuge at 4000r / min for 8 minutes, and dry the precipitate at -60°C to obtain anti-Helicobacter pylori Biopharmaceutical mycelium extract.

Embodiment 2

[0050] An anti-helicobacter pylori biomedical mycelium extract, the extract is prepared according to the following steps:

[0051] (1) Take Hericium erinaceus culture, reflux extraction with 40% ethanol by volume percentage concentration for 3h, then centrifuge at 4000r / min for 58min, remove the medicinal residues, and obtain the extract; wherein, during reflux extraction, Hericium erinaceus The weight ratio of culture to ethanol is 1:10;

[0052] (2) Rotary steam the extract at 50°C until there is no alcohol smell, add water to precipitate the precipitate, then centrifuge at 4000r / min for 8 minutes, and dry the precipitate at -40°C to obtain anti-H. pylori Biopharmaceutical mycelium extract.

Embodiment 3

[0054] An anti-helicobacter pylori biomedical mycelium extract, the extract is prepared according to the following steps:

[0055] (1) Take Hericium erinaceus culture, reflux extraction with 80% ethanol by volume percentage concentration for 2 hours, then centrifuge at 4000r / min for 8 minutes, remove the medicinal residues, and obtain the extract; wherein, during reflux extraction, Hericium erinaceus The weight ratio of culture to ethanol is 1:6;

[0056] (2) Rotary steam the extract at 80°C until there is no alcohol smell, add water to precipitate the precipitate, then centrifuge at 4000r / min for 8 minutes, and dry the precipitate at -60°C to obtain anti-H. pylori Biopharmaceutical mycelium extract.

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Abstract

The invention discloses mycelium extract for a helicobacter pylori-resistant biological medicine and a preparation technology thereof. Hericium erinaceus culture is subjected to reflux-extraction by ethanol having a volume concentration of 40 to 80%; extracting solution is subjected to rotary evaporation at a temperature of 30 to 80 DEG C; and the evaporation products are added with water and precipitates are separated out. The mycelium extract breaks the principle that the prior art mainly utilizes common antibiotics such as amoxicillin, gentamycin, clarithromycin and amoxicillin and an auxiliary acid-inhibition agent (such as a bismuth agent) to treat helicobacter pylori-caused infection, and has obvious treatment effects and small side-effect.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, in particular to mycelia for biomedicine, the extract of which has good anti-helicobacter pylori effect. Background technique [0002] Helicobacter pylori is a spiral-shaped, micro-anaerobic bacteria that requires very harsh growth conditions. In 1983, it was successfully isolated from the gastric mucosal biopsy tissue of patients with chronic active gastritis for the first time. It is the only microbial species known to be able to survive in the human stomach. Helicobacter pylori disease includes gastritis, peptic ulcer, and lymphoproliferative gastric lymphoma caused by Helicobacter pylori infection. The poor prognosis of Helicobacter pylori disease is gastric cancer. [0003] Helicobacter pylori parasitizes in gastric mucosal tissue, and 67%-80% of gastric ulcers and 95% of duodenal ulcers are caused by Helicobacter pylori. The common symptoms of patients with chronic gastritis a...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61P31/04
Inventor 何述金谭桂山常耀台
Owner HUNAN XINHUI PHARMA
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