Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of dihydroartemisinin piperaquine phosphate tablet and preparation method thereof

A technology of piperaquine phosphate tablet and dihydroartemisinin, which is applied in the field of medicine, can solve the problems of slow dissolution rate, achieve rapid dissolution, simple process, and improve production efficiency

Active Publication Date: 2015-08-19
贝克诺顿(浙江)制药有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies of the prior art, the inventor has done a lot of creative work to solve the problem of slow dissolution rate in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of dihydroartemisinin piperaquine phosphate tablet and preparation method thereof
  • A kind of dihydroartemisinin piperaquine phosphate tablet and preparation method thereof
  • A kind of dihydroartemisinin piperaquine phosphate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of Dihydroartemisinin Piperaquine Phosphate Tablets

[0026]

[0027] Preparation Process:

[0028] (1) Dissolve dihydroartemisinin and hydroxypropyl methylcellulose E5 in chloroform;

[0029] (2) Pass the piperaquine phosphate raw material through a 100-mesh sieve, disperse it in the above solution, and pulverize it through a colloid mill to obtain a suspension, the suspension D90=18.4 microns;

[0030] (3) Pass lactose and sodium carboxymethyl starch through a 100-mesh sieve, mix well, and set aside;

[0031] (4) Granulate the suspension in step (2) on the mixed excipients in step (3), dry at 40°C, granulate with a 16-mesh sieve, then add magnesium stearate, mix evenly and press into tablets.

Embodiment 2

[0032] Example 2 Preparation of Dihydroartemisinin Piperaquine Phosphate Tablets

[0033]

[0034] Preparation Process:

[0035] (1) Dissolve dihydroartemisinin and hydroxypropyl methylcellulose E5 in chloroform;

[0036] (2) Pass the piperaquine phosphate raw material through a 100-mesh sieve, disperse it in the above solution, and pulverize it through a colloid mill to obtain a suspension, the suspension D90=12.3 microns;

[0037] (3) Pass sucrose, lactose, sodium carboxymethyl starch and crospovidone through a 100-mesh sieve, mix well, and set aside;

[0038] (4) Granulate the suspension in step (2) on the mixed excipients in step (3), dry at 40°C, granulate with a 16-mesh sieve, then add magnesium stearate and micronized silica gel, mix evenly and press into tablets.

Embodiment 3

[0039] Example 3 Preparation of Dihydroartemisinin Piperaquine Phosphate Tablets

[0040]

[0041]

[0042] Preparation Process:

[0043] (1) Dissolve dihydroartemisinin and hydroxypropyl methylcellulose E5 in chloroform;

[0044] (2) Pass the piperaquine phosphate raw material through a 100-mesh sieve, disperse it in the above solution, and pulverize it through a colloid mill to obtain a suspension, the suspension D90=7.5 microns;

[0045] (3) Pass lactose and crospovidone through a 100-mesh sieve, mix well, and set aside;

[0046] (4) Granulate the suspension in step (2) on the mixed excipients in step (3), dry at 40°C, granulate with a 16-mesh sieve, then add magnesium stearate, mix evenly and press into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses dihydroartemisinin piperaquine phosphate tablets and a preparation method thereof. The tablets are prepared from dihydroartemisinin, piperaquine phosphate, hydroxypropyl methyl cellulose E5, hydrophilic accessory and lubricating agent, wherein the weight ratio of the dihydroartemisinin to the hydroxypropyl methyl cellulose E5 is 1:(1-5). Solid dispersion of the dihydroartemisinin and pulverized piperaquine phosphate can be obtained by adopting one-step operation, so that the production efficiency is improved; and the tablets are dissolved quickly.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a dihydroartemisinin piperaquine phosphate tablet and a preparation method thereof. Background technique [0002] Dihydroartemisinin is the second-generation antimalarial drug of the artemisinin class and is the drug of choice for the treatment of malaria, especially multidrug-resistant falciparum malaria. WHO recommends the combination of artemisinin and other drugs to treat malaria, referred to as ACT therapy, as the first-line antimalarial drug. Dihydroartemisinin-piperaquine tablet is an excellent drug for treating various malaria, especially multidrug-resistant falciparum malaria. It is a compound preparation composed of dihydroartemisinin and piperaquine phosphate. In vitro pharmacodynamic studies have shown that the combination of dihydroartemisinin and piperaquine phosphate has a significant synergistic effect, which can delay the development of drug resista...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K9/20A61P33/06A61K31/357
CPCY02A50/30
Inventor 不公告发明人
Owner 贝克诺顿(浙江)制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com