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High-intensity multi-degradation-resistant-protection degradable internal fracture fixation materials and preparation method thereof

A fixation material and degradation-resistant technology, applied in internal fixers, fixators, internal bone synthesis, etc., can solve the problems of low strength and fast strength loss, achieve slow strength loss, small strength loss, eliminate antigenicity and immune effect

Inactive Publication Date: 2013-09-04
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of low strength and rapid strength loss caused by uncontrollable degradation of degradable fracture internal fixation materials, the present invention provides a degradable fracture internal fixation material with high strength and multiple degradation-resistant protections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Poly(lactic acid-glycolic acid) (the mass ratio of lactic acid and glycolic acid is 85:15) is dissolved in ethyl acetate to form a film solution with a mass concentration of 30%, and then coated on a poly(lactic acid-glycolic acid) with a fineness of 200dtex. (lactic acid-glycolic acid) (the mass ratio of lactic acid and glycolic acid in the copolymer is 60:40), and dry and solidify;

[0030] (2) The fiber is twisted twice to form a fiber bundle, and then a layer of poly(lactic acid-glycolic acid) is coated on the surface of the fiber bundle (the mass ratio of lactic acid to glycolic acid in the copolymer is 85:15) (in step 1 Prepared film solution), and dried and solidified;

[0031] (3) Pull out the fiber bundle from the spool at a speed of 1m / min and guide the braiding point through the guide wheel of the high-speed braiding machine, and weave to obtain the braided rope;

[0032] (4) Dissolving poly(lactic acid-glycolic acid) (the mass ratio of lactic acid to gl...

Embodiment 2

[0036] (1) Poly(lactic acid-glycolic acid) (the mass ratio of lactic acid and glycolic acid is 99:1) is dissolved in ethyl acetate to make a film solution with a mass concentration of 20%, and then coated on a poly(lactic acid-glycolic acid) with a fineness of 300dtex. (lactic acid-glycolic acid) (the mass ratio of lactic acid and glycolic acid in the copolymer is 80:20), and dry and solidify;

[0037] (2) The fiber is twisted twice to form a fiber bundle, and then a layer of poly(lactic acid-glycolic acid) is coated on the surface of the fiber bundle (the mass ratio of lactic acid and glycolic acid in the copolymer is 99:1) (in step 1 Prepared film solution), and dried and solidified;

[0038] (3) fiber bundle is pulled out from the spool with the speed of 10m / min and guided to the braiding point by the guide wheel of the high-speed braiding machine, braiding obtains the braided rope;

[0039] (4) Dissolving poly(lactic acid-glycolic acid) (the mass ratio of lactic acid to g...

Embodiment 3

[0043] (1) Poly(lactic acid-glycolic acid) (the mass ratio of lactic acid and glycolic acid is 90:10) is dissolved in ethyl acetate to form a film solution with a mass concentration of 50%, and then coated on a poly(lactic acid-glycolic acid) with a fineness of 300dtex. (lactic acid-glycolic acid) (the mass ratio of lactic acid and glycolic acid in the copolymer is 70:30), and dry and solidify;

[0044] (2) The fiber is twisted twice to form a fiber bundle, and then a layer of poly(lactic acid-glycolic acid) is coated on the surface of the fiber bundle (the mass ratio of lactic acid and glycolic acid in the copolymer is 90:10) (step 1 The film solution prepared in), and dried and solidified;

[0045] (3) the fiber bundle is pulled out from the spool at a speed of 5m / min and guided to the braiding point by the guide wheel of the high-speed braiding machine, and braided to obtain a braided rope;

[0046] (4) Dissolving poly(lactic acid-glycolic acid) (the mass ratio of lactic a...

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Abstract

The invention provides high-intensity multi-degradation-resistant-protection degradable internal fracture fixation materials and a preparation method of the materials. The internal fracture fixation materials are formed by a degradable braided rope structure and a surface-layer multi-hole structure. The preparation method of the high-intensity multi-degradation-resistant-protection degradable internal fracture fixation materials includes the steps of preparing the braided rope structure through degradable fibers with degradation-resistant protective layers on the surfaces, and then coating the surface of the braided rope structure by degradation-resistant materials to form a multi-hole surface layer. According to the high-intensity multi-degradation-resistant-protection degradable internal fracture fixation materials, the biocompatible degradable materials are completely used, the special inner supporting braided rope structure and multi-degradation-resistant protections on the surface enable a support to have high mechanical intensity and slow intensity losses and also have good biocompatibility and excellent bone conduction performance, and the problems that the internal fracture fixation materials in a use process are not high in intensity, rapid in intensity loss, poor in bone conduction performance and the like are solved.

Description

technical field [0001] The invention relates to a human bone tissue internal fixation material, in particular to a degradable fracture internal fixation material with high strength and multiple degradation-resistant protections and a preparation method thereof. Background technique [0002] Fracture is a common clinical case, which accounts for a high proportion in trauma surgery. The specific treatment measures include reduction, immobilization, rehabilitation training and drug-assisted treatment. Among them, the fixation method is the method widely used in the treatment of fractures and bone injuries at present, and has also achieved good curative effect on the treatment of fractures. Bone internal fixator is an indispensable medical device for the treatment of fractures and bone trauma. A good fracture internal fixation should meet the following conditions: (1) It has good mechanical properties, such as high tensile strength, compressive strength, shear strength, good f...

Claims

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Application Information

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IPC IPC(8): A61B17/68A61L31/06A61L31/14
Inventor 刘必前何敏张海军李青峰陈亮
Owner INST OF CHEM CHINESE ACAD OF SCI
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