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Chinese and western medicine compound preparation containing tilmicosin and preparation method thereof

The technology of tilmicosin and compound preparation is applied to the compound preparation of traditional Chinese and western medicine and its preparation, and the field of treating respiratory diseases of livestock and poultry can solve the problems of cumbersome extraction of traditional Chinese medicine components, troublesome transportation of solution preparations, and high purchase price in the market, and achieves The effect of saving production processes, reducing drug residues, and enhancing immunity

Inactive Publication Date: 2014-07-30
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when tilmicosin is used alone, the course of treatment is longer, the dosage is larger, and the cost is high, which is not conducive to popularization and application in actual production.
[0003] The Chinese invention patent with the patent number ZL 201110066379.2 discloses a tilmicosin compound preparation and its preparation method and application. The tilmicosin compound preparation uses veterinary drugs that have not been approved for use in animals or food animals. The artificially synthesized drug pidotimod has no relevant research on the safety of pidotimod in animal applications and drug residues in food animals, which limits the application of this compound preparation in veterinary drug production and veterinary clinics. practical application
[0004] The Chinese invention patent with the patent number ZL 201010503385.5 discloses a compound tilmicosin oral liquid and its preparation method. The compound tilmicosin preparation uses the traditional Chinese medicine astragalus extract - astragalus polysaccharide, and the traditional Chinese medicine isatidis extract - Chlorogenic acid, the monomer component extracted from isatidis polysaccharide and honeysuckle, these extracted Chinese medicine components are cumbersome to extract by themselves, the market purchase price is high, especially chlorogenic acid, and the quality is difficult to control
Moreover, the compound tilmicosin preparation needs to add various co-solvents and preservatives, which is easy to cause environmental pollution, and its preparation method is troublesome. The various co-solvents and preservatives that need to be added need to be heated for production, and the prepared solution preparations are transported trouble also adds to shipping costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A Chinese and Western medicine compound preparation containing tilmicosin, which is composed of the following components by weight percentage: 20% tilmicosin, 6% taurine, 20% astragalus, 20% Folium Isatidis, and 20% Radix Radix , Starch 14%.

[0029] The preparation method of the above-mentioned Chinese and Western medicine compound preparation containing tilmicosin is as follows:

[0030] 1) Premixing taurine and starch to obtain a premixed material;

[0031] 2) The premixed material obtained in step 1) is mixed with tilmicosin, astragalus superfine powder, Folium Isatidis superfine powder, isatis root superfine powder and the remaining starch to obtain the product.

Embodiment 2

[0033] This embodiment is further improved on the basis of Example 1. The difference is that: the astragalus, Radix Radix, and Folium Folium are all pulverized to ultrafine powder, and the average particle diameters of the Radix Astragali, Radix Radix, and Folium Folium are all between More than 300 mesh.

[0034] Preparation:

[0035] 1) Pulverize astragalus, isatidis, and Folium baicalensis with ultra-fine pulverization equipment, so that their average particle size reaches more than 300 mesh;

[0036] 2) Premixing taurine and starch to obtain a premixed material;

[0037] 3) The premixed material obtained in step 2) is mixed with tilmicosin, astragalus superfine powder, Folium Isatidis superfine powder, isatis root superfine powder and the remaining starch to obtain the product.

Embodiment 3

[0039] A Chinese and Western medicine compound preparation containing tilmicosin, which consists of the following components by weight percentage:

[0040] Tilmicosin 20%, Taurine 5%, Astragalus 30%, Radix Radix 30%, Folium Folium 10%, Starch 5%.

[0041] The preparation method of the above-mentioned Chinese and Western medicine compound preparation containing tilmicosin is as follows:

[0042]1) Pulverize astragalus, isatidis, and Folium baicalensis with ultra-fine pulverization equipment, so that their average particle size reaches more than 300 mesh;

[0043] 2) Premixing taurine and starch to obtain a premixed material;

[0044] 3) The premixed material obtained in step 2) is mixed with tilmicosin, astragalus superfine powder, Folium Isatidis superfine powder, isatis root superfine powder and the remaining starch to obtain the product.

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PUM

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Abstract

The invention discloses a Chinese and western medicine compound preparation containing tilmicosin. The Chinese and western medicine compound preparation containing tilmicosin comprises the following components by mass percent: 2-30% of tilmicosin, 0.5-10% of taurine, 5-30% of milkvetch, 5-30% of isatis root, 5-30% of indigowoad leaf and the balance of officinal filling auxiliary material. The invention also discloses a preparation method of the Chinese and western medicine compound preparation containing tilmicosion. The Chinese and western medicine compound preparation containing tilmicosion has the advantages of stable effect, convenience in application and easiness in preparation when being used for treating respiratory diseases of beasts and birds.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a Chinese and Western medicine compound preparation containing tilmicosin and a preparation method thereof. The Chinese and Western medicine compound preparation is mainly used for treating respiratory diseases of livestock and poultry. Background technique [0002] Tilmicosin is a semi-synthetic macrolide antibiotic for livestock and poultry successfully developed by the British Elanco Animal Health Products Company in the 1980s. It is effective against all Gram-positive bacteria and some Gram-negative bacteria, mycoplasma, Spirochetes, etc. have inhibitory effects, and have a significant effect on infectious diseases caused by sensitive bacteria in pigs, cattle, sheep and other animals, especially respiratory tract infections in livestock and poultry. As a new antibiotic for livestock and poultry, its research is also deepening. The latest research shows that it ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/855A61K36/704A61K36/481A61P11/00A61P31/04A61P31/12A61K31/185A61K31/706
CPCY02A40/70
Inventor 刘小艳方炳虎陈瑞爱袁照红湛穗璋
Owner GUANGDONG WENS DAHUANONG BIOTECH