Oral cavity atomized liquid with cytosine replacing nicotine and preparation method thereof

A technology of genistein and atomized liquid, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, tobacco, etc., can solve the problems of large, very weak, and almost no feeling, and achieve long-lasting fragrance. , reduce dependence, improve the effect of taste

Inactive Publication Date: 2013-09-11
CHANGNING DEKANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The electronic cigarette aerosol liquid disclosed in Chinese patent 200910310536.2 contains 3-5% w / v of tobacco leaf extract, 3-5% w / v of tobacco essence, 0-3% w / v of nicotine, and 0.2-1% w / v of stabilizer / v, thickener 3-8% w / v, pure water 5-10% w / v, propylene glycol 50-70% w / v, and other formulations such as codeine phosphate, chlorpheniramine, etc., although Tobacco leaf extract is used, but it is still a product that imitates the taste of cigarettes and is blended with tobacco leaf extract and other flavors and fragrances
Smokers generally report that compared with cigarettes, e-cigarettes feel like cigarettes in shape, feel, and smoke, but in terms of aroma and taste, there is a big gap between them and cigarettes, especially products that are blended with various flavors and fragrances. , they have difficulty accepting or getting used to its aroma and taste
In addition, at present, the aroma components of e-cigarette liquids are difficult to preserve for a long time, and the best ones can only be stored for about half a year, and the "smoke smell" is very weak or almost gone. This is also a problem commonly reported by users.
These deficiencies have greatly affected the quality of electronic cigarettes, and at the same time restricted the popularity and popularity of electronic cigarettes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Each 1L oral atomization liquid is composed of the following components in mass percentage: 10% of tobacco leaves, 3.6% of cocoa extract, 0.4% of cytisine, 800.2% of Tween, and 85.8% of primer.

[0022] The primer is a mixture of propylene glycol and glycerin in a ratio of 1:3.

[0023] A preparation method of cytisine instead of nicotine oral atomization liquid, which comprises the following steps:

[0024] (1), target volume 500L, take the tobacco leaf of above-mentioned mass-volume ratio by target volume and drop in the extraction jar of band interlayer;

[0025] (2), according to the target volume, measure the Tween 80 of the above mass ratio and the base agent with a mass volume ratio of 70%, pour Tween 80 into the base agent and stir and mix for 30 minutes, and add the mixed solution to the extraction Soak the tobacco leaves in the tank for 50 minutes, then pass steam into the interlayer to heat up to 50°C, keep warm and extract for 4 hours, release the extract a...

Embodiment 2

[0031] A cytisine oral atomization solution for replacing nicotine, each 1L of the oral atomization solution is composed of the following components in mass percentage: 10% of tobacco leaves, 4% of cocoa extract, 0.3% of cytisine, 800.3% of Tween, Primer 85.4%.

[0032] The primer is a mixture of propylene glycol and polyethylene glycol in a ratio of 1:2.

[0033] A preparation method of cytisine instead of nicotine oral atomization liquid, which comprises the following steps:

[0034] (1), target volume 500L, take the tobacco leaf of above-mentioned mass-volume ratio by target volume and drop in the extraction jar of band interlayer;

[0035] (2), respectively measure the Tween 80 with the above mass ratio and the base agent with a mass volume ratio of 76% according to the target volume, pour Tween 80 into the base agent and stir and mix for 30 minutes, and add the mixed solution to the extraction Soak the tobacco leaves in the tank for 60 minutes, then pass steam into the ...

Embodiment 3

[0041] A cytisine oral atomization solution for replacing nicotine, each 1L of the oral atomization solution is composed of the following components in mass percentage: 0.1% of tobacco leaves, 10% of cocoa extract, 0.9% of cytisine, 800.5% of Tween, Primer 88.5%.

[0042] The primer is a mixture of polyethylene glycol and glycerin in a ratio of 1:5.

[0043] A preparation method of cytisine instead of nicotine oral atomization liquid, which comprises the following steps:

[0044] (1), target volume 300L, take the tobacco leaf of above-mentioned mass-volume ratio by target volume and drop in the extraction tank of band interlayer;

[0045] (2), respectively measure the Tween 80 with the above mass ratio and the base agent with a mass volume ratio of 80% according to the target volume, pour Tween 80 into the base agent and stir and mix for 20 minutes, and add the mixed solution to the extraction Soak the tobacco leaves in the tank for 30 minutes, then pass steam into the inter...

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PUM

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Abstract

The invention discloses an oral cavity atomized liquid with cytosine replacing nicotine and a preparation method of the oral cavity atomized liquid. Each liter of oral cavity atomized liquid comprises, by weight, 0.1-10% of tobacco leaves, 0.3-15% of cocoa extractive, 0.1-0.9% of cytosine, 0.1-0.5% Twain 800 and 75-90% of base agents. The tobacco leaves are weighed, put into an extracting tank, an extracting solution is discharged and filtered to obtain filter liquor, the cocoa extractive, the cytosine and the base agents are added and evenly mixed, and the product is obtained. The method has the advantages that natural aroma components in plants enter the oral cavity atomized liquid with the cytosine replacing the nicotine, the oral cavity atomized liquid is closer to the aroma of cigarettes, smoking feeling of a customer can be catered better, further the aroma-staying time of the natural aroma components in the oral cavity atomized liquid is longer, the aroma of an electronic cigarette liquid is enhanced, the taste of the electronic cigarette liquid is improved, and dependency on the nicotine is reduced.

Description

technical field [0001] The invention relates to a cytisine-substituted nicotine oral atomization liquid and a preparation method thereof, belonging to the technical field of chemical preparation. Background technique [0002] Nicotine, commonly known as nicotine, is an alkaloid found in plants of the family Solanaceae (Solanum genus) and is also an important component of tobacco. Nicotine can be addictive or dependent (one of the most difficult addictions to break), people often have difficulty restraining themselves, repeated use of nicotine also increases heart rate and blood pressure and reduces appetite. Large doses of nicotine can cause vomiting and nausea, and in severe cases, people can die. Tobacco often contains nicotine, which keeps many smokers from quitting. However, the current means of smoking cessation generally adopt the nicotine replacement method, and if the control is not good, it still cannot reduce the dependence on nicotine. [0003] Clinically use c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B15/16A24B15/26A24F47/00
CPCA61K9/007A61K31/465A24B15/167A61P25/34A24B15/16
Inventor 郑志炫
Owner CHANGNING DEKANG BIOTECH
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