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Method for preparing long-acting terramycin injection by utilizing carbamide and sodium bisulfite in combined way

A technology of sodium bisulfite and long-acting oxytetracycline, applied in the field of medicine, can solve the problems of short drug effect, poor stability, difficult process control, etc., and achieve the effects of quick effect, maintaining stability and good curative effect.

Inactive Publication Date: 2013-09-11
安徽天安生物科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

my country started the production of such drugs at the beginning of this century, but there is still a big gap compared with foreign products, mainly in poor stability, short drug effect, difficult process control and other problems

Method used

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Embodiment Construction

[0023] Urea and sodium bisulfite are used in combination to prepare the method for long-acting oxytetracycline injection, comprising the following steps:

[0024] (1) Weigh the raw materials of each component according to the following parts by weight (kg):

[0025] Oxytetracycline Hydrochloride 10

[0026] Magnesium chloride 4

[0027] Urea 2

[0028] Sodium thiosulfate 0.5

[0029] Ethanolamine 4.5

[0030] Sodium bisulfite 1

[0031] α-Pyrrolidone 50

[0032] Disodium edetate 0.01

[0033] Water for injection 100;

[0034] (2) Add 20kg of water for injection into the batching tank, add sodium thiosulfate, urea, and magnesium chloride in turn, stir and dissolve until clear;

[0035] (3) Then add α-pyrrolidone to the batching tank, stir evenly, add oxytetracycline hydrochloride, stir and dissolve until clear, and the temperature during the dissolution process is 50°C;

[0036] (4) Slowly add ethanolamine to the above mixture, lower the temperat...

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Abstract

The invention discloses a method for preparing long-acting terramycin injection by utilizing carbamide and sodium bisulfite in a combined way. The long-acting terramycin injection comprises the following raw materials in parts by weight: 10-15 parts of tetramycin hydrochloride, 4-5 parts of magnesium chloride, 2-3 parts of carbamide, 0.5-0.8 part of sodium thiosulfate, 4-6 parts of ethanolamine, 1-1.5 parts of sodium bisulfite, 50-60 parts of alpha-pyrrolidone, 0.01-0.03 part of disodium EDTA and 100-150 parts of water for injection. Compared with the prior art, the long-acting terramycin injection disclosed by the invention has the advantages of high bioavailability, good curative effect, quick effect, definite curative effect and stability in quality and can keep higher biological activity for a longer time and sufficiently keep the stability of a product; the preparation method disclosed by the invention has the advantages of easiness for operation of product preparation, low cost and industrialized large-scale production.

Description

technical field [0001] The invention relates to a method for preparing long-acting oxytetracycline injection by combining urea and sodium bisulfite, belonging to the technical field of medicine. Background technique [0002] Oxytetracycline injection was first successfully developed by Pfizer Pharmaceutical Company of the United States at the end of the last century. It is the drug of choice for treating postpartum hyperthermia syndrome in sows, and it has been popularized rapidly since it went on the market. my country started the production of such drugs at the beginning of this century, but there is still a big gap compared with foreign products, mainly in the problems of poor stability, short drug effect, and difficult process control. Contents of the invention [0003] The object of the present invention is to address the deficiencies in the prior art, to provide a method for preparing long-acting oxytetracycline injection by combining urea and sodium bisulfite, so as...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/65A61K47/02A61K47/16A61P31/04
Inventor 程贤防丁维君
Owner 安徽天安生物科技股份有限公司
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