Pyruvate oral rehydration salt composition for curing circulation hypovolemia or water-losing with salt-losing

A technology of hypovolemia and sodium pyruvate, which is applied in the field of pharmaceutical oral products, can solve the problems that intestinal function cannot directly protect and treat

Inactive Publication Date: 2013-09-25
胡森 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although the existing WHO-ORS has been continuously improved, so far its components do not directly protect and treat intestinal function, but only improve concentration and osmotic pressure to relieve gastrointestinal symptoms; or add auxiliary components , improve the emptying of oral rehydration salt solution, increase the absorption ratio of water and salt and enhance its antibacterial properties, etc. (11-14)

Method used

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  • Pyruvate oral rehydration salt composition for curing circulation hypovolemia or water-losing with salt-losing
  • Pyruvate oral rehydration salt composition for curing circulation hypovolemia or water-losing with salt-losing
  • Pyruvate oral rehydration salt composition for curing circulation hypovolemia or water-losing with salt-losing

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0080] Oral rehydration salt solution containing sodium pyruvate1

[0081] Oral rehydration salt solution 1 is obtained by mixing the substances listed in the following table according to the formula and dissolving in water:

[0082] Table 1 Hypertonic sodium pyruvate oral rehydration salt solution

[0083] essential component

preparation Embodiment 2

[0085] Oral rehydration salt solution containing sodium pyruvate 2

[0086] Oral rehydration salt solution 2 is obtained by mixing the substances listed in the table below and dissolving them in water according to the formula:

[0087] Table 2 Hypertonic sodium pyruvate oral rehydration salt solution

[0088] essential component

preparation Embodiment 3

[0090] Oral rehydration salt solution containing sodium pyruvate3

[0091] Oral rehydration salt solution 3 is obtained by mixing the substances listed in the table below and dissolving them in water according to the formula:

[0092] Table 3 Isotonic sodium pyruvate oral rehydration salt solution

[0093] essential component

[0094] Glucose (anhydrous)

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Abstract

The invention discloses a pyruvate oral rehydration salt composition for curing circulation hypovolemia or water-losing with salt-losing. The composition comprises the following components: (i) 2.0-6.0 parts by weight of sodium pyruvate, (ii) 1.5-17.0 parts by weight of sodium chloride, (iii) 0-2.0 parts by weight of potassium chloride, and (iv) 10.0-50.0 parts by weight of anhydrous glucose or other carbohydrates; and the sum weight of the components (i), (ii), (iii), and (iv) is 50-100 % of the total composition weight.

Description

technical field [0001] The present invention relates to pharmaceutical oral products, in particular to a kind of oral rehydration salts (Pyruvate-enriched Oral Rehydration Salts, Pyr-ORS) containing sodium pyruvate used for circulating hypovolemia or dehydration accompanied by desalination states such as shock and diarrhea combination. Background technique [0002] In the treatment of hypovolemic shock caused by severe blood loss, trauma, and dehydration, especially in the treatment of massive burn (scald) shock, early and rapid blood volume supplementation is the key medical measure for anti-shock. However, at the scene of war, severe natural disasters, epidemics or sudden accidents (such as forest fires, terrorist attacks), there are often batches of shock wounded in a short period of time. Due to difficulties such as limited environmental and medical conditions, conventional intravenous anti-shock methods (such as Blood transfusion, transfusion) are difficult or delayed,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K45/00A61P1/00A61P1/12A61P7/08A61P17/02A61P31/04A61K31/19A61K31/194A61K31/70A61K31/7004
CPCA61K9/0019A61K9/08A61K31/19A61K31/194A61K31/198A61K31/355A61K31/375A61K31/522A61K31/7004A61K33/04A61K33/06A61K33/14A61K33/30A61K33/42A61K45/06A61P1/00A61P1/12A61P3/00A61P7/00A61P7/08A61P17/00A61P17/02A61P31/04A61K2300/00Y02A50/30
Inventor 胡森周方强
Owner 胡森
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