Process and device for improving utilization rate of ethylene oxide of metronidazole production raw materials

A technology of ethylene oxide and metronidazole, which is applied in the field of technology and equipment to improve the utilization rate of ethylene oxide as a raw material for the production of metronidazole, can solve the problems of low utilization rate of ethylene oxide, and is beneficial to environmental protection , good environmental benefits, and the effect of enhancing market competitiveness

Active Publication Date: 2015-05-20
黄冈银河阿迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] As can be seen from the above, metronidazole is prepared through heterogeneous chemical synthesis, and the utilization rate of ethylene oxide is very low, so there is a lot of room for improving the utilization rate of ethylene oxide

Method used

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  • Process and device for improving utilization rate of ethylene oxide of metronidazole production raw materials
  • Process and device for improving utilization rate of ethylene oxide of metronidazole production raw materials

Examples

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Embodiment 1

[0032] Embodiment 1: the technique of improving metronidazole production raw material oxyethane utilization rate of the present invention, it comprises the steps:

[0033] The first material is started, and the initial feeding of the three kettles is as follows: the pre-reaction kettle and the pre-dissolution kettle are respectively put into 150kg of nitrates, 80kg of formic acid and 80kg of sulfuric acid; the synthesis reactor is put into 150kg of nitrates, 105kg of formic acid and sulfuric acid 95 kg.

[0034] Start the car, feed ethylene oxide at a flow rate of 60kg / h, and feed time for 180 minutes, and control the reaction temperature of the synthesis reactor at 89-93°C. The temperature of the pre-reactor is controlled at 80±2°C; the temperature of the pre-dissolving kettle is controlled at 35±5°C. After the operation of feeding ethylene oxide is completed, the reaction is kept for 30 minutes, the synthetic reaction is completed, and the vehicle is shut down.

[0035] Re...

Embodiment 2

[0043] Embodiment 2: the technique of improving metronidazole production raw material oxyethane utilization rate of the present invention, it comprises the steps:

[0044] The first material is started, and the initial feeding of the three kettles is as follows: the pre-reaction kettle and the pre-dissolution kettle are respectively put into 150kg of nitrates, 80kg of formic acid and 80kg of sulfuric acid; the synthesis reactor is put into 150kg of nitrates, 105kg of formic acid and sulfuric acid 95 kg.

[0045] Start the car, feed ethylene oxide at a flow rate of 60kg / h, and feed time for 180 minutes, and control the reaction temperature of the synthesis reactor at 89-92°C. The temperature of the pre-reactor is controlled at 80±2°C; the temperature of the pre-dissolving kettle is controlled at 35±5°C. After the operation of feeding ethylene oxide is completed, the reaction is kept for 30 minutes, the synthetic reaction is completed, and the vehicle is shut down.

[0046] Re...

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Abstract

The invention discloses a process and a device for improving a utilization rate of ethylene oxide of metronidazole production raw materials. The process comprises: during chemical synthesis preparation of metronidazole, two identical reaction kettles are added and arranged above a hydroxylation reaction kettle, and the three kettles are arranged in series at the device height direction according to an upper, middle and lower order. In the manner of flowing from top to bottom and under the action of high-position differences, liquid phase materials flow from the pre-dissolving kettle to the pre-reaction kettle, and then flow to the synthesis reaction kettle through pipelines by self; in the manner of flowing from bottom to top and under the action of pressure differences between the three kettles, gas phase materials flow from the synthesis reaction kettle to the pre-reaction kettle, then flow to the pre-dissolving kettle through pipelines, and finally are dragged by a draw-off pump. Gas escaping from the hydroxylation reaction kettle is cooled to condense with cold water, tail gas discharged by the pre-dissolving kettle is cooled to condense with salt water, and the inletting time of ethylene oxide is shortened, so that the process and the device enable the utilization rate of ethylene oxide to be increased by more than one time, reduce the discharge of three wastes, reduce the production cost, greatly improve the process efficiency, and have quite good environmental, social and economic benefits.

Description

technical field [0001] The invention relates to the production field of metronidazole prepared by chemical synthesis, in particular to a process and equipment for improving the utilization rate of ethylene oxide, a raw material for metronidazole production. Background technique [0002] The raw materials used in the synthesis of metronidazole are as follows: formic acid is used as a catalyst, sulfuric acid is used as an adjusting solvent (a total of liquid phase), and 2-methyl-5-nitroimidazole (abbreviated as nitrate) is used as a precursor compound (dissolved in a liquid phase) ; Ethylene oxide is a hydroxyethylating agent (for the gas phase). [0003] Ethylene oxide has a low boiling point (10.7°C), and the normal state is in the gas phase, while the temperature of the hydroxylation reaction is about 91°C, so ethylene oxide participates in the reaction in the gaseous state (that is, the gas phase), and the hydroxylation synthesis of metronidazole is heterogeneous. phase c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D233/94
Inventor 张怀松黄刚明
Owner 黄冈银河阿迪药业有限公司
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