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Method for preparing N-acetyl-D-glucosamine

A technology for glucosamine and glucosamine hydrochloride, applied in the field of preparing N-acetyl-D-glucosamine, can solve the problems of high price of chitinase, high production cost, difficult industrialization and the like, and achieve good economic benefits and social effects , low cost, few steps

Inactive Publication Date: 2013-10-30
YANGZHOU HONGXIN BIOLOGICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing methods for preparing NAG include hydrolysis and enzymatic hydrolysis. The hydrolysis uses chitin through the action of HCl, and NAG can be obtained under mild conditions, but the yield is low
Enzymatic hydrolysis of chitin to obtain NAG monomer through the action of chitinase, but due to the high price of chitinase, the production cost is high and it is difficult to industrialize

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add 1.5t of edible alcohol into a 2000L reactor, add 300kg of triethylamine, stir for 0.5h, add 300kg of D-glucosamine hydrochloride, stir for 1h, control the temperature at -5~0℃, add 1kg of catalyst, start Add 300L acetic anhydride dropwise. The temperature during the entire dripping reaction was controlled below 5°C and pH 4 was maintained. After the dripping of acetic anhydride is completed, add 1kg of cracking agent to maintain stirring for 2h, centrifuge the material and wash twice with alcohol. Dissolve the wet product in the reaction kettle with water, add 10kg activated carbon and 10kg safety agent to decolorize and filter press when heated to 50~60℃, the filtrate enters the reactor after sand filtration, and concentrate in vacuum at -0.1~0.09MPa, 50~55℃ . When a large number of crystals are produced, stop the concentration, cooling and discharging, centrifuge, wash with alcohol, and dry to obtain the finished product. According to the different requirements ...

Embodiment 2

[0016] Add 1.5t of edible alcohol into a 2000L reactor, add 300kg of triethylamine, stir for 1h, add 375kg of D-glucosamine hydrochloride, stir for 2h, control the temperature at -5~0℃, add 2kg of catalyst, start dripping Add 375L of acetic anhydride. The temperature during the entire dripping reaction was controlled below 5°C and pH 4 was maintained. After the dripping of acetic anhydride, 2kg of cracking agent was added to maintain stirring for 3h, centrifuged and washed twice with alcohol. Dissolve the wet product in the reactor with water, heat up to 50~60℃, add 20kg activated carbon and 20kg safety agent to decolorize and filter press, the filtrate enters the reactor after sand filtration, and concentrates in vacuum at -0.1~0.09MPa, 50~55℃ . When a large number of crystals are produced, stop the concentration, cooling and discharging, centrifuge, wash with alcohol, and dry to obtain the finished product. According to the different requirements of users, it can be crushe...

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PUM

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Abstract

The invention discloses a method for preparing N-acetyl-D-glucosamine. The method comprises the following steps of: (1) adding edible alcohol and triethylamine into a reaction kettle, stirring, adding D-glucosamine hydrochloride, stirring for 1-2 hours, controlling the temperature at minus 5-0 DEG C, adding quantitive catalysts, and starting dropwise adding acetic anhydride; (2) adding cracking agents after finishing the adding of the anhydride, maintaining the stirring for 2-3 hours, discharging and centrifuging the material, and washing the material by utilizing the alcohol, so as to obtain a wet product; (3) adding water to dissolve the wet product, heating to 50-60 DEG C, adding activated carbon and assurance agents to carry out decoloration and filter pressing, carrying out sand filtering on filter liquid and introducing the filter liquid to enter the reaction kettle, carrying out vacuum concentration at the pressure of minus 0.1-0.09 MPa and the temperature of 50-55 DEG C, stopping the concentration until a large number of crystals are generated, cooling and discharging the material, centrifuging and washing the crystals by utilizing the alcohol, and drying the crystals, so as to obtain finished products. The method for preparing the N-acetyl-D-glucosamine has the advantages that the yield is high, the cost is low, the steps are few, the industrialization is liable, the practicality is good, and good economic benefits and social effects can be generated.

Description

Technical field [0001] The invention relates to N-acetyl-D-glucosamine, in particular to a method for preparing N-acetyl-D-glucosamine. Background technique [0002] N-Acetyl-D-Glucosamine (NAG) is a monomer of chitin. It has very important physiological functions in medicine. It has anti-inflammatory, anti-tumor and antioxidant effects, and is effective in treating osteoarthritis and rheumatoid arthritis. Medicines have important uses in the food, chemical and cosmetic industries. The existing methods for preparing NAG include a hydrolysis method and an enzymatic hydrolysis method. The hydrolysis method uses chitin and HCl to obtain NAG under mild conditions, but the yield is low. Enzymatic hydrolysis method Nail chitin can obtain NAG monomer through the action of chitinase, but because chitinase is expensive, the production cost is high and it is difficult to industrialize. Summary of the invention [0003] Objective of the invention: In view of the deficiencies in the prior a...

Claims

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Application Information

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IPC IPC(8): C07H5/06C07H1/00
Inventor 杨生桂
Owner YANGZHOU HONGXIN BIOLOGICAL PRODS