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Application of a sesquiterpene compound in the preparation of acaricide

A technology of sesquiterpenoids and compounds, which is applied in the field of application of sesquiterpenoids in the preparation of acaricidal drugs, and can solve the problems of no compound acaricidal effect

Active Publication Date: 2015-11-25
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the acaricidal effect of this compound

Method used

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  • Application of a sesquiterpene compound in the preparation of acaricide
  • Application of a sesquiterpene compound in the preparation of acaricide
  • Application of a sesquiterpene compound in the preparation of acaricide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The acquisition of embodiment 1 sesquiterpenoids

[0047] Obtaining Eupatorium adenophorum petroleum ether extract: Eupatoria adenophorum whole herb dry powder was obtained by drying Eupatoria adenophorum collected in Xichang City, Sichuan naturally and then pulverizing. Take 8kg of Eupatorium adenophorum whole herb dry powder, extract it three times with 8-10 times of 95% ethanol heat reflux respectively, and then combine the extracts and concentrate under reduced pressure to obtain the ethanol extract of Eupatorium adenophorum. The obtained Eupatorium adenophorum ethanol extract was dispersed in 4 L of water, extracted three times with 4 L of petroleum ether, and separated to obtain petroleum ether extract.

[0048] Sample mixing: Take 48g of the obtained petroleum ether extract, add a proper amount of acetone until it dissolves. Weigh 98g of 200-300 mesh column chromatography silica gel and put it in an evaporating dish, put the evaporating dish on a water bath at 6...

Embodiment 2

[0062] The in vitro insecticidal activity of embodiment 2 sesquiterpenoids is measured

[0063] Isolate and collect scabs from the ear canal of New Zealand rabbits severely infected with itchy mite, place them in a glass plate, and place the plate in a 35°C incubator for 0.5h-1h. After crawling out from the scab, the vigorous itchy mite that crawled out was picked for the experiment.

[0064] The sesquiterpenoids with the structure obtained in Example 1 as shown in formula I were tested for in vitro insecticidal activity,

[0065]

[0066] Formula I.

[0067] The experiment consisted of an experimental group, a blank control group and a positive control group. Wherein, the reagent used in the experimental group is the sesquiterpenoid solution obtained in Example 1 of different concentrations, in g / mL, the mass volume concentration of the sesquiterpenoid compound with the structure shown in formula I in the reagent used in the experimental group is respectively 0.5%, 0.25...

Embodiment 3

[0079] The clinical treatment of embodiment 3 sesquiterpenoids to rabbit itch mite

[0080] In order to further verify the clinical therapeutic effect of the sesquiterpenoids with the structure shown in formula I on animal acariasis, the sesquiterpenoids with the structure shown in formula I obtained in Example 1 are used to treat rabbit itches treatment of mites,

[0081]

[0082] Formula I.

[0083] Randomly select 30 New Zealand rabbits infested with itch mite from the rabbit farm where itch mite broke out. The selected New Zealand rabbits are of similar age and weight, and the degree of infection in the left ear and right ear is similar. Treat with other miticides. At the same time, the New Zealand rabbits selected for testing were in good immunity and had no infection with other diseases. The selected 30 rabbits were randomly divided into 5 groups, 6 rabbits in each group, respectively marked as group A, group B, group C, group D and group E for testing. Simultaneo...

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Abstract

The invention belongs to the field of pharmaceutical chemistry, and discloses an application of sesquiterpenoids compound on preparation of miticides and miticides containing the sesquiterpenoids compound. In the application of sesquiterpenoids compound on preparation of miticides, the structure of the used sesquiterpenoids compound is shown as the formula I. When the sesquiterpenoids compound is used for killing mites, the compound has a prominent effect on killing mites, and has a killing effect on animal mites. Furthermore, the compound belongs to natural plant source miticides, has the characteristics of difficult generation of drug resistance, self degradation in the environment, no residual or enrichment through food chains in livestock products, and relative safety for people, livestock and environment, and is capable of being applied to prepare miticides, formula I.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to the application of a sesquiterpene compound in the preparation of acaricides. Background technique [0002] Mites (Acarid) belong to invertebrates, Arthropoda, Arachnida, and subclass Acarid. Most mites are soft and very small, and can be seen with the naked eye, generally 0.1 mm to several mm. At present, there are about 50,000 kinds of known mites, which parasitize underground, on the ground, in mountains, in water, and on people or organisms, infecting various diseases or endangering crops. Animal acariasis is a kind of contact, contagious and intractable skin disease caused by mites of Scabies, Pythrocarpiidae and Demodexidae parasitizing on the skin of animals, characterized by severe itching and severe skin inflammation of sick animals. feature. Animal mite disease spreads all over the world. It is commonly known as "mange" in Chinese folk. It generally occurs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61P33/14
Inventor 杨光友农向古小彬彭雪蓉
Owner SICHUAN AGRI UNIV