Functional carbon wrapping Fe3O4 multihole nanocomposite and preparing method thereof and application of functional carbon wrapping Fe3O4 multihole nanocomposite serving as drug carrier

A nanocomposite material, carbon coating technology, applied in the field of nanomaterials, can solve the problems of low porosity, application limitation, low specific surface area, etc.

Inactive Publication Date: 2015-04-15
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these carbon-coated Fe 3 o 4 The common characteristics of nanocomposites are: low specific surface area, low porosity, and the material surface has not been further functionalized to increase its functional groups, so carbon-coated Fe 3 o 4 Applications of nanocomposites are limited

Method used

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  • Functional carbon wrapping Fe3O4 multihole nanocomposite and preparing method thereof and application of functional carbon wrapping Fe3O4 multihole nanocomposite serving as drug carrier
  • Functional carbon wrapping Fe3O4 multihole nanocomposite and preparing method thereof and application of functional carbon wrapping Fe3O4 multihole nanocomposite serving as drug carrier
  • Functional carbon wrapping Fe3O4 multihole nanocomposite and preparing method thereof and application of functional carbon wrapping Fe3O4 multihole nanocomposite serving as drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062](1) Add 2g of reduced iron powder and 30mL of 2mol / L nitric acid solution into the reactor, stir to fully dissolve; then apply a 0.4T magnetic field at the bottom of the reactor, and slowly inject ammonia gas into the reactor Mixed gas with air (the volume ratio of ammonia gas to air is 8:1); when the pH value reaches 10, stop feeding the gas, gradually raise the temperature to 70°C, seal the reactor, and keep it for 3 hours; the obtained product is washed and vacuum-dried , get Fe 3 o 4 Nano flower-like nanoparticles;

[0063] (2) Weigh 0.1gFe 3 o 4 Nano flower-like particles, dispersed in 10mL aqueous solution containing 0.4g polyvinyl alcohol and sonicated for 20 minutes; respectively added 4.5g p-toluenesulfonic acid and 0.035g galactose, stirred vigorously and mixed for 30 minutes; the mixture was transferred to an autoclave In the process, react at 100°C for 1 hour, then gradually raise the temperature to 185°C, and carbonize for 8 hours; after cooling, extract...

Embodiment 2

[0066] (1) Add 2g of reduced iron powder and 30mL of 2mol / L nitric acid solution into the reactor, stir to fully dissolve; then apply a 0.6T magnetic field at the bottom of the reactor, and slowly inject ammonia gas and Mixed gas of air (the volume ratio of ammonia gas to air is 8:1); when the pH value reaches 11, stop feeding the gas, gradually raise the temperature to 70°C, seal the reactor, and keep it for 4 hours; the obtained product is washed, vacuum-dried, Get Fe 3 o 4 Nano flower-like nanoparticles;

[0067] (2) Weigh 0.1gFe 3 o 4 Nano flower-like particles, dispersed in 10mL aqueous solution containing 0.4g polyvinyl alcohol and sonicated for 20 minutes; respectively added 4.5g p-toluenesulfonic acid and 0.04g galactose, vigorously stirred and mixed for 30 minutes; the mixture was transferred to an autoclave In the process, react at 100°C for 1 hour, then gradually raise the temperature to 185°C, and carbonize for 8 hours; after cooling, extract the product with a...

Embodiment 3

[0070] (1) Add 2g of reduced iron powder and 30mL of 2mol / L nitric acid solution into the reactor, stir to fully dissolve; then apply a 0.6T magnetic field at the bottom of the reactor, and slowly inject ammonia gas and Mixed gas of air (the volume ratio of ammonia gas to air is 8:1); when the pH value reaches 12, stop feeding the gas, gradually raise the temperature to 75°C, seal the reactor, and keep it for 5 hours; the obtained product is washed, vacuum-dried, Get Fe 3 o 4 Nano flower-like nanoparticles;

[0071] (2) Weigh 0.1gFe 3 o 4 Nano flower-like particles, dispersed in 10mL aqueous solution containing 0.45g polyvinyl alcohol and sonicated for 20 minutes; respectively added 3.5g p-toluenesulfonic acid and 0.035g galactose, stirred vigorously for 30 minutes; the mixture was transferred to a high-pressure reactor In the process, react at 100°C for 1 hour, then gradually raise the temperature to 185°C, and carbonize for 8 hours; after cooling, extract the product wit...

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Abstract

The invention provides a functional carbon wrapping Fe3O4 multihole nanocomposite, and belongs to the technical field of composite materials. Reduced iron serves as a raw material, and after being dissolved by nitric acid, the reduced iron is co-precipitated under the induction of a magnetic field, and then a multihole flower-shaped Fe3O4 nanostructure is obtained. Polyving akohol serves as a cross-linking agent, p-methylbenzene sulfonic acid serves as a surface active agent, the multihole flower-shaped Fe3O4 nanostructure and galactose are mixed and are carbonized at high temperature, a carbon wrapping multihole flower-shaped Fe3O4 nanostructure is obtained and is processed by a strong oxidant, and the functional carbon wrapping Fe3O4 multihole nanocomposite with the surface modified is obtained. The nanocomposite is superior in saturation magnetization, large in specific surface area and void fraction, stable in performance and obvious in absorbing organic drugs with amidogen, hydroxyl, carboxyl and epoxy groups, and has potential application prospects in the aspect of drug targeting releasing.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials and relates to a functionalized carbon-coated Fe 3 o 4 Porous nanocomposites (C / Fe 3 o 4 ) and preparation method thereof; the present invention also relates to functionalized carbon-coated Fe 3 o 4 Application of porous nanocomposites as drug carriers. Background technique [0002] Since magnetic material carriers are used as targeted drugs to treat tumor cells in vivo, people have invested a lot of work and energy in targeted drug materials. Compared with traditional drugs, the main advantage of targeted drug materials is that they can control the drug site, and the drug can be delivered to the affected area quickly and accurately. It is also possible to remove the carrier and the remaining drug by applying an external magnetic field so that it can be discharged through the kidneys in time, thereby reducing the accumulation time of the drug in other parts of the body and reducing the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K47/02
Inventor 张春莫尊理王博滕桂香郭瑞斌张平
Owner NORTHWEST NORMAL UNIVERSITY
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