Tacrolimus slow-releasing capsule and preparation method thereof

A technology for tacrolimus and sustained-release capsules is applied in the field of tacrolimus sustained-release capsules and its preparation, which can solve the problems of low utilization rate of raw materials and excipients, and achieve economical packaging methods, universal packaging equipment, and preparation technology. mature effect
CN103432099AInactive Publication Date: 2013-12-11JIANGSU QINGJIANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU QINGJIANG PHARMA
Publication Date
2013-12-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a tacrolimus slow-releasing capsule and a preparation method thereof. The tacrolimus slow-releasing capsule is a pellet capsule and has the characteristic of slowness in releasing, and is stable in dissolution degree and good in bioavailability. According to the preparation method, tacrolimus and relative auxiliary materials are prepared into coating liquid, the coating liquid is wrapped on pellet cores to form micro pellets in a coating manner, and the capsule is prepared after packing. Since the crushing, grinding or filtering of the bulk drugs or the auxiliary materials are needless in the preparation process, the bulk drugs and the auxiliary materials can be utilized to the greatest extent, as a result, the problem in the conventional preparation method of the tacrolimus slow-releasing capsule that the utilization rate of the bulk drugs and the auxiliary materials is low since composition containing the tacrolimus is required to be smashed and sieved, is solved.
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Description

technical field

[0001] The invention relates to a slow-release capsule whose main component is tacrolimus used in the field of medicine and a preparation method thereof. technical background

[0002] Tacrolimus is a macrolide antibiotic that can be used as an immunosuppressive drug after organ transplantation. It is mainly used to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Its chemical structure is as follows:

[0003]

[0004] Tacrolimus sustained-release capsule is a sustained-release preparation that only needs to be taken orally once a day. At present, the preparation method of this sustained-release preparation is to prepare tacrolimus raw material drug and excipients such as hypromellose and ethyl cellulose into a solid dispersion composition, and then encapsulated into capsules (such as Chinese patent ZL99806415.7). Since tacrolimus is a poorly soluble substance, in order to effectively control its particle s...

Claims

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