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Oral medicinal preparation containing glycosyl modified polyphenolic substance and application of oral medicinal preparation

A polyphenol compound and glycosyl modification technology, applied in the field of medicine, can solve the problems of complex natural polyphenol composition, restricted application, difficult preparation and quality control, etc., and achieve the effects of simple preparation method, easy operation and good water solubility.

Active Publication Date: 2015-03-04
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Polyphenolic compounds in natural products, such as tea polyphenols, resveratrol, glucose proanthocyanidins and apple polyphenols, have a certain effect on weight loss and blood fat reduction, but most of the natural polyphenols are complex and difficult to prepare and quality control. Seriously restrict their application as medicine or health products

Method used

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  • Oral medicinal preparation containing glycosyl modified polyphenolic substance and application of oral medicinal preparation
  • Oral medicinal preparation containing glycosyl modified polyphenolic substance and application of oral medicinal preparation
  • Oral medicinal preparation containing glycosyl modified polyphenolic substance and application of oral medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 tablet

[0030] Get 100g glycosyl-modified polyphenol compound, add 50g starch, 10g magnesium stearate, 20g carboxymethylcellulose, 270g ethanol (volume percentage content is 70%), 250g microcrystalline cellulose, 320g cornstarch, fully stir and mix Made into wet granules, dried at 60-70°C for 2-4 hours and pressed into tablets. Tablets are made into tablets. The excipients used as excipients include magnesium sulfate, corn starch, and talcum powder. The specifications are: 5mg, 10mg, 20mg, 50mg, and 100mg.

[0031] In actual operation, the glycosyl-modified polyphenol compound is a compound shown in the following formula:

[0032]

[0033] Among them, R 1 =R 2 =H or OH,R 3 =H or OH or NH 2 or OCH 3 .

Embodiment 2

[0034] Embodiment 2 capsules

[0035] Take 150g of glycosyl-modified polyphenol compounds, add 20g of magnesium stearate, 200g of carboxymethyl cellulose, and 480g of microcrystalline cellulose, stir and mix thoroughly to make wet granules, and dry the prepared wet granules directly at 60-70°C After 2-4 hours, it is washed and filled into empty capsule shells, and each capsule contains 25 mg of glycosyl-modified polyphenol compounds.

Embodiment 3

[0036] Embodiment 3 sustained and controlled release tablet

[0037] Get 75g of glycosyl-modified polyphenol compounds, add 35g of hydroxypropylmethylcellulose, 125g of carboxymethylcellulose, 135g of ethanol (volume percentage concentration is 70%), 5g of magnesium stearate, etc. and fully stir and mix to make wet granules , Dry at 60-70°C for 2-4 hours and press into tablets.

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Abstract

The invention discloses an oral medicinal preparation containing a glycosyl modified polyphenolic substance. Each unit dosage of the oral medicinal preparation contains 1-200mg of glycosyl modified polyphenolic substance, wherein the unit dosage is the total amount of the medicinal preparation used each day. The glycosyl modified polyphenolic substance can be combined with other medicaments or used independently, can be added with a pharmaceutically acceptable medical carrier to enable the glycosyl modified polyphenolic substance to account for 0.5-60 percent of the total weight of the medicinal preparation, and tablets, pills, capsules, granules, suspension, aerosol, oral solutions and sustained-release preparations can be prepared. The invention also provides applications of the medicinal preparation in preparing weight-reducing medicines, weight-reducing health-care products, blood-fat reducing medicines and blood-fat reducing health-care products. The oral medicinal preparation containing the glycosyl modified polyphenolic substance is good in water solubility, can be used for treating obesity with a remarkable weight-reducing effect, in particular treating obesity caused by diet, heredity and reduction of metabolism, can be used for treating hyperlipidemia with a remarkable blood-fat reducing effect, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an oral pharmaceutical preparation containing glycosyl-modified polyphenol compounds and its application in the preparation of weight-loss medicines, weight-loss health care products, blood lipid-lowering medicines and blood fat-lowering health care products. Background technique [0002] With the development of the global economy, obesity has gradually become a serious chronic disease faced by all mankind. The latest statistics from the World Health Organization show that in 2008, more than one tenth of the adults in the world were overweight, of which more than 200 million men and nearly 300 million women were obese; as of 2010, nearly 43 million children under the age of 5 were overweight Condition. In 2002, the Ministry of Health's survey on nutrition and health status of Chinese residents showed that the adult obesity rate in my country was 7.1%, and the estim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7032A61K31/05A61K31/136A61K31/09A61P3/04A61P3/06
Inventor 刘天军杨晓姣洪阁杨澍
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI